An Immunohistochemical Study of Endocrine Cells in the Abomasum of Vagotomized Calf.

Abstract

ABSTRACT. The effect of thoraco-vagotomy on the distribution and frequency of chromogranin-, serotonin-, somatostatin-and gastrinimmunoreactive cells in the abomasum of the calf were investigated by immunohistochemistry. Calves were vagotomized at 1 week old and sampled 2 and 4 weeks later. The endocrine cells generally decreased in number in vagotomized calves as compared to non-operated control calves. However, the detailed responses of endocrine cells to vagotomy varied depending on the endocrine cell type, region of gastric mucosa, and period after vagotomy. The present result suggests that the vagus nerve has an influence on the intrinsic regulatory system by endocrine cell control in the ruminant abomasum.

Immunohistochemical and electron‐microscopic identification of neuroendocrine cells in the stomach of uremic rats

“…Numerous DNES cells present in alimentary tract epithelium produce biologically active substances and ensure coordination of all functions of digestive organs. Reports are available indicating some changes in the number of these cells in various pathological conditions, thus confirming the active involvement of enteroendocrine cells in pathological processes of the alimentary tract (Fujimiya et al, 1991;Osadchuk et al, 1989;Panfilov et al, 1989;Ratner et al, 1990;Soehartono et al, 2002). It can be assumed that the increased number of APUD cells and reaction intensity observed in this study to a certain degree compensates for homeostatic disorders associated with the impairment of renal parenchyma functioning.…”

“…Reports are available indicating some changes in the number of these cells in various pathological conditions, thus confirming the active involvement of enteroendocrine cells in pathological processes of the alimentary tract (Fujimiya et al, 1991;Osadchuk et al, 1989;Panfilov et al, 1989;Ratner et al, 1990;Soehartono et al, 2002). Numerous DNES cells present in alimentary tract epithelium produce biologically active substances and ensure coordination of all functions of digestive organs.…”

“…By the production of these biologically active substances, amine precursor uptake and decarboxylation (APUD) cells are directly involved in the regulation of many metabolic processes and are regulators of homeostasis via neurocrine, endocrine and paracrine mechanisms (Kvetnoy et al, 2000). Any disorder of the APUD system involving excessive production or deficiency of a hormone or biogenic amine may cause dysfunction of body systems, which manifests itself in a complex set of clinical symptoms (Kvetnoi and Iakovlova, 1987;Soehartono et al, 2002). In recent years, many scientists have been concerned with the structure, function and histogenesis of APUD cells, as well as their involvement in various pathological processes.…”

You Are What You (First) Eat

“…Limited studies also suggest that vagal innervation of the gastrointestinal tract promotes survival and proliferation of enteroendocrine cells. In mice and calves, vagotomy reduces the density of enteroendocrine cells in the stomach (Qian et al, 1999 ; Soehartono et al, 2002 ). Although the moment of synapse formation between the vagus nerve and enteroendocrine cells remains unknown, the early development of vagal innervation and similarities in signaling molecules suggest that the gut and brain contact early in embryonic life.…”

Evaluation of differences between breeds for substance P, vasoactive intestinal polypeptide, and neurofilament 200 in the abomasal wall of cattle

“…Additionally, no differences have been detected concerning the spontaneous activity of smooth muscle specimens in vitro. 17 Immunohistochemical studies [18][19][20][21][22][23][24][25] on the gastrointestinal tract of ruminants are limited and basically deal with the distribution pattern of nervous structures, endocrine cells, and neuropeptides within the gastrointestinal wall. [18][19][20][21][22][23][24][25] Until now, a comparison of breeds by means of immunohistochemistry has not been performed.…”