An Investigation into the Intrinsic Peroxidase‐Like Activity of Fe‐MOFs and Fe‐MOFs/Polymer Composites

Abstract

The quest for developing materials that provide a perfect trade‐off between factors such as enzyme‐like response, stability, and low cost has been a long‐standing challenge in the field of biosensing. Metal‐organic frameworks (MOFs) and their composites have emerged as promising candidates for biosensing applications due to their exceptional properties such as tunable pore size, high specific surface area, and exposed active sites. A comparative study of the intrinsic peroxidase‐like activity of five different MOF materials: Fe‐BTC, NH2‐MIL‐101(Fe), composites of Fe‐BTC with polymers polydopamine (PDA), poly p‐phenylenediamine (PpPDA), and poly(3,4‐ethylenedioxythiophene) is reported for the detection of H2O2, an important biomarker in biomedical diagnostics. The response of these materials toward H2O2 via electrochemical and colorimetric techniques is mapped and it is found that, at neutral pH, the Fe‐BTC/PEDOT composite exhibits the highest sensitivity and activity compared to other MOF materials in this study. The results indicate that the combination of unique properties of Fe‐BTC and conducting polymer PEDOT, improves the peroxidase‐like activity of the Fe‐BTC/PEDOT composite compared to the individual components. This work presents a new opportunity for easy‐to synthesize and low‐cost MOFs/conducting polymer composites for biosensing applications and provides significant insights to achieve rational design of composites with desirable functional properties

MOFs-Derived Zn-Based Catalysts in Acetylene Acetoxylation

“…MOFs are crystalline nanoporous materials with a framework structure composed of transition metal ions and organic ligands [ 18 ], with the metal components dispersed one by one through organic ligands. On account of the large specific surface area, abundant pore structure, and surface defects of MOFs, MOFs have become a research hotspot in the fields of gas storage, gas adsorption, separation, sensors, drug controllable release, and catalytic reactions [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Because of their excellent chemical and thermal stability, MOFs are also used as a template or precursor for the preparation of porous carbon materials or metal composite materials [ 26 ].…”

Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

“…Many researchers have attempted to overcome this barrier by combining MOFs and polymers. Thakur et al ( Thakur et al, 2021 ) grew polymer monomers in the pores of the synthesized MOFs and verified that conjugate polymerization does not degrade the structure of MOFs. The addition of poly (3,4-ethylenedioxythiophene) (PEDOT) remarkably improves the inherently poor conductivity of Fe-BTC (BTC = 1,3,5-benzenetricarboxylic acid) MOF.…”

Simple preparation of Ag-BTC-modified Co3Mo7O24 mesoporous material for capacitance and H2O2-sensing performances

“…63 In addition, oxidase-based biotransducers used to detect analytes such as glucose mainly depend on the change of H 2 O 2 concentration during the reaction process. 64,65 Compared with traditional sensors, electrochemical sensors have the characteristics of high sensitivity and fast response. 66 In recent years, POMOFs have attracted extensive attention because of their high conductivity and high stability.…”