An Organ System-Based Synopsis ofPseudomonas aeruginosaVirulence

Abstract

Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a wide variety of environments, and in the process, making it a notorious opportunistic pathogen. Apart from the extensively studied chronic infection in the lungs of people with cystic fibrosis (CF), P. aeruginosa also causes multiple serious infections encompassing essentially all organs of the human body, among others, lung infection in patients with chronic obstructive pulmonary disease, primary ciliary dyskinesia and ventilator-associated pneumonia; bacteremia and sepsis; soft tissue infection in burns, open wounds and postsurgery patients; urinary tract infection; diabetic foot ulcers; chronic suppurative otitis media and otitis externa; and keratitis associated with extended contact lens use. Although well characterized in the context of CF, pathogenic processes mediated by various P. aeruginosa virulence factors in other organ systems remain poorly understood. In this review, we use an organ system-based approach to provide a synopsis of disease mechanisms exerted by P. aeruginosa virulence determinants that contribute to its success as a versatile pathogen.

Pharmacological validation of Solanum mammosum L. as an anti-infective agent: Role of solamargine

“…Pyocyanin is a blue redox-active secondary metabolite that is readily recovered in large quantities in sputum from patients with cystic fibrosis. Pyocyanin can cross the cell membrane and causes oxidative stress by generating reactive oxygen and nitrogen species, which allow P. aeruginosa to kill competitor microbes inhabiting the same niche, as well as damaging host cells or modulating their immune signaling (Morin et al, 2021). In this study, our data indicate that Solamargine has a significant effect on P. aeruginosa biofilm formation and pyocyanin production under our conditions, which brings new insights about the potential of this plant to treat respiratory problems.…”

Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release

“…These microbes are the most frequently separated from severe wounds, and their colonization necessitates careful management. When tissues are traumatically injured, this can result in a wound infection [43]. We found structural components of tissues (including fascia) that cause virulent P. aeruginosa to be produced by scavenging iron ions and affect the host immune system.…”

Surface motility favors co-dependent interaction between Pseudomonas aeruginosa and Burkholderia cenocepacia

“…P. aeruginosa is a Gram-negative opportunistic pathogen infecting immunocompromised individuals and patients with defective barrier defenses (11). When chronically infecting in CF lungs, it induces a lethal decline in respiratory function (5, 12).…”