Patient compliance is a determining factor for successful therapy, especially for long-term treatment such as diabetes mellitus. Purpose: The aim of this study was to determine the level of adherence and the influence of the characteristics of patients with type 2 diabetes mellitus in using drugs at the Regional General Hospital of La Temmamala, Soppeng. Thirty respondents who met the entry criteria in this study. Data were obtained prospectively. Respondents were interviewed using a demographic questionnaire and an MMAS-8 questionnaire (Morisky Medication Adherence Scale-8). The results of the study showed low compliance level of 43.3%, medium 36.7%, and high 20.0%. Exercising status, co-morbidities, regimen therapy, and checking fasting blood sugar gave significant results on the level of adherence (p<0.05). other factors such as level of educational factors, profession, duration of diagnosis, dietary pattern, smoking, and the varian drug had no effect on compliance (p>0.05). Compliance of most respondents was low (43.3%). Exercise status, comorbidities, regimen therapy, and fasting blood sugar test results are the factors that affect adherence.