Analysis of bioactive chemical components of two medicinal plants (Coriandrum sativum and Melia azedarach) leaves using gas chromatography-mass spectrometry (GC-MS)

Al-Marzoqi, Ali Hussein; Hameed, Imad Hadi; Idan, Salah Ali

doi:10.5897/ajb2015.14956

Cited by 76 publications

(14 citation statements)

References 26 publications

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“…Some acid compounds also showed antimicrobial activity ( Himaman et al, 2016 ). Hexadecanoic acid,2- hydroxy-1-(hydroxymethyl) ethyl ester extracted from medicinal plants ( Melia azedarach leaves) had antioxidant, anti-inflammatory, and anthelmintic activities ( Ali et al, 2015 ). Thus, we speculated that these compounds play a key role in the broad-spectrum antifungal activity of Streptomyces sp.…”

Section: Discussionmentioning

confidence: 99%

A Novel Antifungal Actinomycete Streptomyces sp. Strain H3-2 Effectively Controls Banana Fusarium Wilt

et al. 2021

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Banana Fusarium wilt disease caused by Fusarium oxyspoum f. sp. cubense (Foc) seriously threatens the banana industry. Foc tropical race 4 (Foc TR4) can infect almost all banana cultivars. Compared with traditional physical and chemical practices, biocontrol strategy using beneficial microbes is considered as an environmentally sound option to manage fungal disease. In this study, a strain, H3-2, isolated from a non-infected banana orchard, exhibited high antifungal activity against Foc TR4. According to its morphological, physiological, and biochemical characteristics, the strain H3-2 was identified as Streptomyces sp. and convinced by the polymorphic phylogenic analysis of 16S rRNA sequences. Extracts of the strain H3-2 suppressed the growth and spore germination of Foc TR4 in vitro by destroying cell membrane integrity and mycelial ultrastructure. Notably, the strain and its extracts showed broad-spectrum antifungal activity against the selected seven fungal phytopathogens. Fourteen chemical compounds in the extracts were identified by gas chromatography–mass spectrometer (GC-MS), primarily phenolic compounds. Additional pot inoculation experiment demonstrated that the fermentation broth of the strain H3-2 promoted the growth of banana seedlings by efficiently inhibiting the spread of banana Fusarium wilt disease. This study demonstrated the potential application of the novel Streptomyces sp. H3-2 for the management of banana Fusarium wilt.

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Section: Discussionmentioning

confidence: 99%

A Novel Antifungal Actinomycete Streptomyces sp. Strain H3-2 Effectively Controls Banana Fusarium Wilt

et al. 2021

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“…Some studies have mentioned that camphor, spathulenol, and farnesol found in the composition of C. heyneana volatile oil have various pharmacological activities. Camphor may enhance the immune system, and spathulenol may have strong antioxidants and prevent inflammation, while farnesol may reduce oxidative stress and inflammation (18)(19)(20). Therefore, various chemical compounds in C. heyneana contribute in different ways to protect the liver from injury.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Hepatoprotective Activity of the Curcuma heyneana Rhizome Extract toward Wistar Rats Induced by Ethanol

Marianne

Mariadi

Nugraha

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Curcuma heyneana (Valeton & Zijp.) or temu giring has various pharmacological activities. However, its hepatoprotective activity toward ethanol induction has never been carried out. Objectives: The objective of this research was to evaluate the hepatoprotective activity of the C. heyneana rhizome extract toward Wistar rats induced by ethanol. Methods: The research was initiated with the determination of curcuminoid content, total phenolic content, total flavonoid content, and characterization of extract using gas chromatography-mass spectrometry (GC-MS). Hepatoprotective activity was tested using the C. heyneana extract at doses of 50, 100, and 150 mg/kg with 5 g/kg ethanol as an inducer. Aspartate transaminase (AST), alanine transaminase (ALT), liver weight, and macroscopic and microscopic liver were used as parameters. Data were analyzed using analysis of variance (ANOVA). Results: The curcuminoid content of the extract was 1.18% (w/w). Total phenolic content of the C. heyneana extract was 400.37 mg gallic acid equivalent (GAE)/g sample, while total flavonoid content was 27.25 mg quercetin equivalent (QE)/g sample. Nine compounds were identified in the extract. Administration of the extract at doses of 50, 100, and 150 mg/kg kept the liver normal. It was identified macroscopically from the dark red color without any white spot and normal liver weight. Furthermore, at doses of 50, 100, and 150 mg/kg, the extract inhibited AST and ALT elevation, which was significantly different from the negative control group (P < 0.05). The extract also prevented hepatocyte injury that was seen microscopically. Conclusions: It can be concluded that the C. heyneana extract at doses of 50, 100, and 150 mg/kg is effective as hepatoprotective in the liver injury induced by ethanol.

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“…A substantial number of active components were also separated and identified from different chinaberry parts, such as leaves, bark, fruit, and seeds. A substantial number of compounds extracted by methanol were found using GC-MS in chinaberry leaves, and the results demonstrated that the extracts contained trichloromethane, 2-pyrrolidinyl-methylamine, propanedioic acid, diethyl ester, and 2-piperidimethanamine, among others ( Al-Marzoqi et al 2015 ). The ethanol extracts of chinaberry leaves exhibited significant antimicrobial activity to several bacteria, including S. aureus .…”

Section: Discussionmentioning

confidence: 99%

“…The human pathogens Enterococcus faecalis, E. coli, P. aeruginosa and Klebsiella oxytoca were susceptible to extracts from chinaberry leaves, particularly the petroleum ether fraction that consists of secondary metabolites, such as alkaloids, terpenes/sterols, saponins, tannins and anthocyanins ( Rojas Sierra et al 2012 ). A variety of compounds have been found in the methanolic extracts from chinaberry, including propanedioic acid, butanedioic acid, diethyl ester, 2-pyrrolidinyl-methylamine, 2-piperidimethanamine, and trichloromethane ( Al-Marzoqi et al 2015 ). In addition, a substantial number of different ingredients were also isolated and identified from chinaberry by different research groups, which repeatedly demonstrated that the components of extracts varied with the extracted parts, solvents, and methodology.…”

Section: Introductionmentioning

confidence: 99%

Chemical Components of Aqueous Extracts of Melia azedarach Fruits and Their Effects on The Transcriptome of Staphylococcus aureus

Peng

Wang

et al. 2021

Polish Journal of Microbiology

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Staphylococcus aureus is the causative agent of numerous and varied clinical infections. Crude aqueous extracts of Melia azedarach fruits inhibit the planktonic growth and initial biofilm formation of S. aureus in a dose-dependent manner. Moreover, the biofilm topologies became sparse and decreased as the concentration of the aqueous extracts increased. RNA-Seq analyses revealed 532 differentially expressed genes (DEGs) after S. aureus exposure to 0.25 mg/l extracts; 319 of them were upregulated, and 213 were downregulated. The majority of DEGs were categorized into abundant sub-groups in the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, untargeted UHPLC-MS/MS analyses of the aqueous extracts of M. azedarach fruits demonstrated a highly complex profile in positive and negative electrospray ionization modes. The extracts primarily consisted of lipids and lipid-like molecules, organic acids and their derivatives, phenylpropanoids, polyketides, organoheterocyclic compounds, and benzenoids, annotated by abundant lipid maps and KEGG pathways. Overall, this study provides evidence that the aqueous extracts of M. azedarach fruits can control S. aureus infections and sought to understand the mode of action of these extracts on S. aureus.

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Analysis of bioactive chemical components of two medicinal plants (Coriandrum sativum and Melia azedarach) leaves using gas chromatography-mass spectrometry (GC-MS)

Cited by 76 publications

References 26 publications

A Novel Antifungal Actinomycete Streptomyces sp. Strain H3-2 Effectively Controls Banana Fusarium Wilt

A Novel Antifungal Actinomycete Streptomyces sp. Strain H3-2 Effectively Controls Banana Fusarium Wilt

Characteristics and Hepatoprotective Activity of the Curcuma heyneana Rhizome Extract toward Wistar Rats Induced by Ethanol

Chemical Components of Aqueous Extracts of Melia azedarach Fruits and Their Effects on The Transcriptome of Staphylococcus aureus

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