Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer

Farzaneh, Farah; Noghabaei, Giti; Barouti, Esmat; Pouresmaili, Farkhondeh; Jamshidi, Javad; Fazeli, Atena; Taghavi, Shaghayegh; Emamalizadeh, Babak; Darvish, Hossein

doi:10.7314/apjcp.2016.17.s3.23

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…Our results are in line with some previous reports in different population like Indian,[30] Danish,[31] and American,[32] and different Iranian ethnic like Gilaki[33] and Fars. [34] Their finding revealed that there is no correlation between polymorphism M2 of CYP1A1 gene and breast cancer risk. Contrary to our results, some reports pointed out that there is a positive association between this polymorphism and risk of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Association of CYP1A1 M2 (A2455G) polymorphism with susceptibility to breast cancer in Mazandaran Province, Northern Iran: A case–control study

et al. 2019

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Background: Breast cancer is one of the most frequent women malignancies in the world. The cytochrome P450 1A1 ( CYP1A1 ) is a key enzyme in xenobiotics metabolism. Moreover, CYP1A1 plays a critical role in the etiology of breast cancer by involving in 2-hydroxylation of estrogen. Therefore, single-nucleotide polymorphisms (SNPs) of its coding gene have been verified to be important in cancer susceptibility. The aim of the study was to evaluate the association of CYP1A1 M2 (A2455G) includes rs1048943 of this SNP polymorphism with the risk of breast cancer in Mazandaran province. Methods: Ninety-six breast cancer patients with known clinicopathological characters and 110 healthy women as control were genotyped for CYP1A1 M2 polymorphisms by the restriction fragment length polymorphism technique. Results: The analysis of CYP1A1 gene (polymorphism M2) showed that the frequency of homozygous wild genotypes (AA), heterozygous (AG), and mutant genotype (GG) in the patient group, respectively, 78%, 22%, and 0%, and also the frequency of genotypes AA, AG, and GG in healthy included 82%, 16%, and 2%, respectively. Statistical analysis by Logistic regression model at P < 0.05 showed no significant correlation between polymorphisms in CYP 1A1M2 and breast cancer risk (odds ratio = 0.84, confidence interval = 0.33–2.17). Conclusions: The results indicated that the M2 allelic genotypes were significantly associated neither with breast cancer risk nor with clinicopathological characteristics in Mazandaran province.

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Section: Discussionmentioning

confidence: 99%

Association of CYP1A1 M2 (A2455G) polymorphism with susceptibility to breast cancer in Mazandaran Province, Northern Iran: A case–control study

et al. 2019

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“…Breast cancer (BC), the second most common cause of cancer-associated mortality in women worldwide, is a heterogeneous disorder accompanied by systemic symptoms, including hot flushes, insomnia and mood changes, as well as local symptoms, including urogenital atrophy and vaginal dryness ( 1 , 2 ). According to a World Health Organization report published in 2015, the incidence of BC is 19.4 per 100,000 women in East Africa and 89.7 per 100,000 women in Western Europe ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer

et al. 2018

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The present study aimed to investigate the diagnostic and prognostic values of contrast-enhanced ultrasound (CEUS) combined with diffusion-weighted magnetic resonance imaging (DW-MRI) in different subtypes of breast cancer (BC). CEUS and DW-MRI were conducted in 232 patients with BC prior to surgical treatment. Patients were categorized as having the luminal A subtype, the luminal B subtype, triple-negative subtype or the human epidermal growth factor receptor 2 (Her-2)-positive subtype according to their expression of the estrogen receptor (ER), progesterone receptor (PR) and Her-2, as detected by immunohistochemistry. The CEUS and DW-MRI parameters of patients with different subtypes of BC were obtained and analyzed. The risk factors for the prognosis of patients with different subtypes of BC were analyzed using Kaplan-Meier and COX regression analyses. The diagnostic accuracy rate of CEUS combined with DW-MRI (93.10%) was higher than that of CEUS (88.79%) or DW-MRI (82.33%) alone. The local recurrence rate and distant metastasis rate of the Her-2-positive subtype were the highest among all the subtypes. Furthermore, patients with Her-2-positive BC exhibited a higher proportion of lesions with indistinct margins and histological grade III. Lymph node metastasis and BC subtype were independent risk factors for the prognosis of BC. The overall survival and disease-free survival of patients with the luminal A subtype were higher than those of patients with the Her-2-positive subtype. The results of the current study therefore indicate that CEUS combined with DW-MRI is more effective at diagnosing the different subtypes of BC than either CEUS or DW-MRI alone.

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“…2 So far, the etiology of breast cancer has not been fully understood, but it was discovered that the development of breast cancer is associated with genetic and environmental factors as well as obesity, while hormone replacement therapy may also lead to breast cancer. 3 – 5 At present, traditional methods, such as sentinel lymph node biopsy, are typically used to determine the staging of breast cancer, but they are associated with high cost and technical complexity. 6 A new technology named contrast-enhanced ultrasound (CEUS) provides an earlier assessment of intrahepatic cholangiocarcinoma and hepatocellular carcinoma, as well as providing a prediction of neoadjuvant chemotherapy efficiency.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic values of contrast-enhanced ultrasound in breast cancer: a retrospective study

Zhao¹,

Liu²,

Hu³

et al. 2017

OTT

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This study aimed to explore the diagnostic and prognostic values of contrast-enhanced ultrasound (CEUS) in breast cancer. Between September 2009 and October 2011, a total of 143 breast cancer patients and 161 healthy people were selected as case group and control group, respectively. After the identification of lesions by conventional ultrasound, all patients underwent CEUS. The CEUS images were analyzed, and time–intensity curves (TICs) were obtained. Hematoxylin–eosin and immunohistochemistry staining was performed on tissue specimens, according to which the expressions of estrogen receptor (ER), c-erb-B2, p53, and Ki-67 were measured. Multivariate logistic regression analysis was used to compare CEUS and TIC parameters between the two groups. Compared with the control group, cancer patients showed high enhancement, heterogeneous enhancement or defects in the central region, expansion of lesion diameter after enhancement and crab-like blur lesion edges. The peak intensity (PI), relative start time of enhancement, relative PI, and relative area under the curve in the case group were significantly higher than those in the control group. Logistic analysis showed that the uniformity of enhancement, expansion of lesion diameter, and relative PI were significant diagnostic parameters of breast cancer, with area under the curve being 0.798, 0.776, and 0.919, respectively. There were strong associations between CEUS characteristics and expressions of prognostic factors in breast cancer: the heterogeneous enhancement was common in c-erb-B2-positive tumors; the centripetal enhancement occurred more in ER-negative tumors; perforator vessels were often seen in tumors at high histological grade; perfusion defects were common in ER-negative, c-erb-B2-positive, and Ki-67-positive tumors. CEUS is a useful tool for the early diagnosis and prognosis of breast cancer.

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Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer

Cited by 11 publications

References 19 publications

Association of CYP1A1 M2 (A2455G) polymorphism with susceptibility to breast cancer in Mazandaran Province, Northern Iran: A case–control study

Association of CYP1A1 M2 (A2455G) polymorphism with susceptibility to breast cancer in Mazandaran Province, Northern Iran: A case–control study

Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer

Diagnostic and prognostic values of contrast-enhanced ultrasound in breast cancer: a retrospective study

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