Analysis of montmorillonite clay as a vehicle in platinum anticancer drug delivery

Porous clay heterostructures: A new inorganic host for 5-fluorouracil encapsulation

“…27 Like in case of synthetic clays (pillared clays, mesoporous silica), 28 the PCH properties (pores dimension, BET surface area, adsorption 29 capacity) depend on the synthesis conditions (surfactant type, 30 surfactant concentration, co-surfactant type, ratio between start-31 ing layered silicate: silica precursor: co-surfactant) (Santos et al,32 2010; Zapata et al, 2013;Nunes et al, 2008;Chmielarz et al, 33 2009a,b,c;Betega de Paiva et al, 2008;Capková et al, 2006;Hedley 34 et al, 2007;Zhou et al, 2004). 35 The advantageous properties of natural and synthetic clays 36 recommend these materials in a wide range of applications, like 37 heterogeneous catalysts, molecular sieves, adsorbents, decontam-38 ination agents and drug delivery systems (Qu et al, 2009;39 Chmielarz et al, 2009a,b,c;Arellano-Cárdenas et al, 2010;Pires 40 et al, 2008;Ku zniarska-Biernacka et al, 2011;Nguyen-Thanh et al, 41 2006; Apps et al, 2014).…”

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

“…Since the knowledge of their physical and chemical properties, the applications of montmorillonites were primarily focused on drug delivery systems [9]. The use of montmorillonite as a carrier of drugs has been reported by some researchers such as chlorhexidine acetate [10], platinum anticancer complex in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite [11], gallic acid [12] and gentamycin [13]. Among the numerous studies, the use of montmorillonite as carrier of metformin HCl has not been reported.…”

Pancreatic cancer therapy using an injectable nanobiohybrid hydrogel

“…The therapeutic agents can be intercalated into interlayer galleries or adsorbed onto negatively charged surfaces of MMT and released in a controlled manner. [41][42][43][44][45][46] Moreover, MMT has been proved nontoxic to tissues and a variety of cells. 47,48 Recently, the combination of inorganic nanoparticles and biodegradable polymeric hydrogels to create nanobiohybrid hydrogels for drug and protein delivery has steadily grown in terms of research and application.…”