2018
DOI: 10.1186/s13065-018-0436-z
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Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold® capsules using spectrophotometric techniques

Abstract: Paracetamol (PAR), Pseudoephedrine hydrochloride (PSE) and cetirizine dihydrochloride (CET) is a ternary mixture that composes tablets which are popular for the relief of flu in Egypt. The spectra of the drugs were overlapped and no spectrophotometric methods were reported to resolve the mixture. This research proposes four spectrophotometric methods that are efficient and require water only as a solvent. The first method was ratio subtraction-ratio difference method (RSDM) where PAR was initially removed from… Show more

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Cited by 18 publications
(5 citation statements)
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“…A variety of analytical approaches have been utilized for quantification of AA such as spectrometry [ 7 ], chemiluminescence [ 8 ], fluorimetry [ 9 ], high performance liquid chromatography (HPLC) [ 10 ] and capillary electrophoresis (CE) [ 11 ]. Also, different analysis types are applied for PAR including fluorescence spectrophotometry [ 12 ], ultraviolet-visible (UV–Vis) spectrophotometry [ 13 ] and HPLC [ 14 ]. However, chromatographic and spectrophotometric techniques need the use of organic solvents, substantial preparatory sample pre-treatment, laborious derivatization phases, mathematical analysis of data, and expensive instrumentation which justify the development of reliable, affordable and simpler techniques [ 15 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…A variety of analytical approaches have been utilized for quantification of AA such as spectrometry [ 7 ], chemiluminescence [ 8 ], fluorimetry [ 9 ], high performance liquid chromatography (HPLC) [ 10 ] and capillary electrophoresis (CE) [ 11 ]. Also, different analysis types are applied for PAR including fluorescence spectrophotometry [ 12 ], ultraviolet-visible (UV–Vis) spectrophotometry [ 13 ] and HPLC [ 14 ]. However, chromatographic and spectrophotometric techniques need the use of organic solvents, substantial preparatory sample pre-treatment, laborious derivatization phases, mathematical analysis of data, and expensive instrumentation which justify the development of reliable, affordable and simpler techniques [ 15 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Several methods, like HPLC [ 16 26 ], HPTLC [ 27 ], spectrophotometric [ 28 31 ], chemmometric method [ 32 34 ], and electrochemical methods [ 35 38 ], have been reported for the assay of PCM. Several methods have been reported for the assay of ETO, including HPLC methods [ 39 – 44 ], HPTLC [ 45 ], spectrophotometric method [ 46 ], LC–MS/MS method [ 47 ], and ion-selective electrode method [ 48 ].…”
Section: Introductionmentioning
confidence: 99%
“…A literature survey reveals that numerous analytical methods have been developed for the assay of PAR and PSE in combination with other antihistaminic drugs ( 9–11 ).…”
Section: Introductionmentioning
confidence: 99%