Analysis of the Relationship between the Levels of Carcinoembryonic Antigen and Lactate Dehydrogenase, and the Neutrophil/Lymphocyte Ratio in Colorectal Cancer

Çelik, Sebahattin; Yılmaz, Mehmet

doi:10.4172/2469-9756.1000119

Cited by 2 publications

(2 citation statements)

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“…RNL associated with CEA levels has been reported in several studies. 12,[17][18][19][20] In contrast, type II macrophages (M2) moderate the inflammatory response, eliminate the residual apoptotic neutrophil, increase angiogenesis by producing proangiogenic cytokines, such as Vascular Endothelial Growth Factor (VEGF)-A, VEGF-C, TNF-α, IL-8; and stimulate the production of arginase for cell replication, collagen deposition, and tissue repair. TAMs often express as M2 phenotype when the tumor is vascular, developing, and invading.…”

Section: Discussionmentioning

confidence: 99%

“…TAMs often express as M2 phenotype when the tumor is vascular, developing, and invading. 15,18 Lymphocytes are the fundamental component of the innate and adaptive immune system and play a role in cellular immunosurveillance and immunoediting, and tumor suppression. Lymphocytes infiltrate the microtumor environment and trigger of the immuneantitumor response.…”

Section: Discussionmentioning

confidence: 99%

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Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and carcinoembrionic antigen level in colorectal cancer

Candrawati¹,

Utomo²,

Sofii

2018

JKKI

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Background: Colorectal cancer is one of cancer that has a high mortality rate. Cancer is associated with a systemic inflammatory response. Carcinoembryonic antigen (CEA) is a colorectal cancer prognostic marker, but this examination is quite expensive and not always ubiquitously available. Therefore, systemic inflammatory markers through routine blood examination are expected as a colorectal cancer marker. Objective: The present study is to determine a correlation of neutrophillymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), the lymphocyte-monocyte ratio (LMR) and CEA level in colorectal cancer patients. Methods: This retrospective cross-sectional study was conducted in November 2016-January 2017 at Dr. Sardjito Hospital, Yogyakarta. As many as 209 patients who underwent surgery in January 2015-Decemberr 2016 with colorectal cancer histopathologic diagnosis were included. Demographic, clinical, histopathology and preoperative NLR, PLR, LMR and CEA level was obtained from medical records. Correlation of NLR, PLR, LMR and CEA level was analyzed with Somer's test. Result: As many as 51.2% of subjects were male. Most subjects (n 42.6%) were diagnosed at 45-60 years old. The most common location of the tumor is in rectum (65.1%). Histopathology examination showed well differentiation in 51.7% subjects. The Somer's analysis showed there was correlation of NLR and CEA level (p=0.023, r=0.164), there was a correlation between PLR and CEA level (p=0.016, r=0.146). Higher NLR and PLR was proportional to higher CEA level. There was a correlation of LMR and CEA level (p=0.001, r=-0.188), lower LMR correlates to higher CEA level. Conclusion:There is significant positive correlation of NLR and CEA level, PLR and CEA level, and negative correlation of LMR and CEA level in colorectal cancer patients.Latar Belakang: Kanker kolorektal merupakan kanker dengan angka kematian yang tinggi. Kanker berhubungan dengan respon inflamasi sistemik. Carcinoembryonic antigen (CEA) merupakan penanda yang diperhitungkan dalam prognostik kanker kolorektal namun cukup mahal dan tidak selalu ada. Oleh karena itu, penanda inflamasi sistemik melalui pemeriksaan darah rutin diharapan dapat dikembangkan sebagai penanda pada kanker kolorektal.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and carcinoembrionic antigen level in colorectal cancer

Candrawati¹,

Utomo²,

Sofii

2018

JKKI

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Relación neutrófilos-linfocitos en tumores sólidos.

Lopez¹,

Caicedo

Velasco

et al. 2020

Rev.Col.Hematol.Oncol

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Introducción: la asociación entre el cáncer y la inflamación ha despertado gran interés en los últimos años. La relación neutrófilos/linfocitos (NLR) se ha utilizado como valor pronóstico y de desenlace clínico en cáncer. Objetivo: determinar la NLR elevada (>2,5) con el estadio clínico, metástasis y demás marcadores de severidad en pacientes con tumores sólidos. Materiales y métodos: estudio transversal analítico, incluyendo 170 historias clínicas de pacientes con tumores sólidos, no expuestos a quimioterapia, que describen las características clínicas y la asociación de la NLR con el estadio clínico, tipo histológico, grado de diferenciación, perfil molecular y metástasis. Los análisis se realizaron con regresión logística, Stata versión 12.0. Resultados: 76% mujeres, mediana de 63 años, cáncer de mama 61,1%, próstata 12,3%, colon 15,8%, pulmón 5,8% y ovario 4,7%. La NLR >2,5 se asoció con estadio avanzado de enfermedad (III y IV) OR: 6,38 (IC95% 1,67-24,4) p=0,007 y OR 4,6 (IC95% 1,13-19) p=0,033, respectivamente, tumores mal diferenciados OR 2,91 (IC IC95% 1,01-4,5) p= 0,046 y metástasis visceral OR= 4,7 (IC95% 2,2-9,9) p=0,000. No se encontró asociación entre el NLR y el tipo histológico, perfil molecular en cáncer de mama, escala de Gleason en cáncer de próstata, ni metástasis óseas. Conclusiones: el radio neutrófilos/linfocitos elevado se asoció en este estudio con estadio avanzado de enfermedad, tumores mal diferenciados y metástasis visceral. Se requiere ampliar la muestra con el fin de confirmar estos resultados, y en el futuro, realizar estudios que se relacionen con eficacia terapéutica.

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Analysis of the Relationship between the Levels of Carcinoembryonic Antigen and Lactate Dehydrogenase, and the Neutrophil/Lymphocyte Ratio in Colorectal Cancer

Cited by 2 publications

References 0 publications

Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and carcinoembrionic antigen level in colorectal cancer

Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and carcinoembrionic antigen level in colorectal cancer

Relación neutrófilos-linfocitos en tumores sólidos.

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