2020
DOI: 10.1049/mnl.2020.0389
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Anti‐cancer combination therapy by co‐delivery of hydrophilic and hydrophobic using dual temperature and pH‐responsive liposomes

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Cited by 7 publications
(6 citation statements)
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“…Given the limitations in combination chemotherapy, nanocarriers have become powerful vehicles for the co-delivery of different drugs [9][10][11][12][13]. In the last few decades, nanocarriers of different materials, such as liposomes [14,15], micelles [16,17] and mesoporous silica [18], have been developed to co-deliver hydrophobic/hydrophilic drugs. However, many of these encapsulate drugs noncovalently, which may lead to inaccurate drug loading and inevitably premature drug leakage during blood circulation [19].…”
Section: Introductionmentioning
confidence: 99%
“…Given the limitations in combination chemotherapy, nanocarriers have become powerful vehicles for the co-delivery of different drugs [9][10][11][12][13]. In the last few decades, nanocarriers of different materials, such as liposomes [14,15], micelles [16,17] and mesoporous silica [18], have been developed to co-deliver hydrophobic/hydrophilic drugs. However, many of these encapsulate drugs noncovalently, which may lead to inaccurate drug loading and inevitably premature drug leakage during blood circulation [19].…”
Section: Introductionmentioning
confidence: 99%
“…[ 96 ] They undergo a phase transitions at specific temperatures for controlled drug release or targeted delivery. [ 97 ]…”
Section: Ultrasound‐sensitive Intelligent Nanosystemsmentioning
confidence: 99%
“…Another interesting development is combining pH-sensitivity with other stimuli (i.e., dual/multi-stimuli responsive NPs); NPs responsive to more than one trigger offer an efficient delivery to the targeted sites with highly controlled drug release and reduced systematic toxicity. Nezhadali et al [ 82 ] synthesized pH and temperature-responsive liposomes encapsulating DOX and mitomycin C. The maximum release (98%) from the developed system was obtained at 40 °C and pH 5.5; only 15% was released at 37°C and physiological pH (7.4). In another study, Luo et al [ 83 ] combined NIR phototherapy and chemotherapy to enhance the anti-cancer effects of gold nanoshells coated liposomes.…”
Section: Challenges and Opportunitiesmentioning
confidence: 99%