Anti- Candida activity assessment of Pelargonium graveolens oil free and nanoemulsion in biofilm formation in hospital medical supplies

Giongo, Janice Luehring; Vaucher, Rodrigo de Almeida; Fausto, Viviane Pedroso; Quatrin, Priscilla Maciel; Lopes, Leonardo Quintana Soares; Santos, Roberto Christ Vianna; Gündel, André; Gomes, Patrícia; Steppe, Martin

doi:10.1016/j.micpath.2016.08.013

Cited by 29 publications

(21 citation statements)

References 41 publications

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“…Our results of C . albicans growth inhibition is in agreement with the previously reported literature where in ultrafine lipid nanocarriers can easily fuse with Candida cell membrane disturbing the membrane integrity and eventually resulting in loss of cell viability [ 41 ].…”

Section: Resultssupporting

confidence: 92%

Resurrection of Nalidixic Acid: Evaluation of Water-Based Nanoformulations as Potential Nanomedicine

et al. 2018

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Resistance to quinolone antibiotics has been a serious problem ever since nalidixic acid was introduced into clinical medicine. Over time, resistance of pathogenic microbes to nalidixic acid led to the design of novel variants to revive its potential application. In the present work, a series of eight nanoformulations of nalidixic acid-based diacyl and sulfonyl acyl hydrazine derivatives were prepared. All nanoformulations were found to be stable at different storage temperatures. Antibacterial and anticandida activity of the eight nanoformulations presented encouraging results when compared with their non-nano parent counterparts. The nanoformulations of chloro, furanyl, and sulfonyl acyl substituted derivatives of nalidixic acid displayed most promising results (MIC ranging from 50 to 100 μg mL−1) against the tested bacteria and yeast. Among the screened bacteria, Acinetobacter baumannii displayed maximum sensitivity to the above nanoformulations. Biosafety study on the mammalian model—wax moth, Galleria mellonella—showed that all eight prepared nanoformulations were absolutely nontoxic to the larvae and subsequent pupae and hence may likely have no or low toxicity against mammalian systems.Graphical Abstract Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2718-8) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 92%

Resurrection of Nalidixic Acid: Evaluation of Water-Based Nanoformulations as Potential Nanomedicine

et al. 2018

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“…The pH of the NEG had only a significant variation in temperature of 25±2 °C in an analysis of 60 d. However, it was observed that the NEB had their pH values decreased significantly after 30 d at 25±2 °C, 60 d at 4±2 °C and 7 d at 45±2 °C (table 4). The pH values were similar to those reported by Giongo et al [13].…”

Section: Physicochemical Properties Of Nanoemulsionssupporting

confidence: 91%

“…All formulations were prepared in triplicate and stored under protection from light and at room temperature. The nanoemulsions were prepared as reported by [13].…”

Section: Physicochemical Characterization Of Nanoemulsionsmentioning

confidence: 99%

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Development of Nanoemulsion Containing Pelargonium Graveolens Oil: Characterization and Stability Study

Giongo¹,

Vaucher

Ourique

et al. 2016

Int J Pharm Pharm Sci

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Objective: To develop, characterize and evaluate the stability of nanoemulsions containing geranium oil (NEG) at different temperatures (4 °C, 25 °C and 45 °C) for 90 d. Methods:The quantification of oil in the nanostructure was performed by gas chromatography-mass spectrometry (GC-MS). The NEG was prepared in Ultra-Turrex and characterized by determining the particle size, polydispersity indices and pH. The thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC) and transmission electron microscopy (TEM) to evaluate the thermal stability of the compounds, the thermal events and morphological analyses of NEG, respectively. Results:The results allow us to suggest that the use the ultra-turrax method is a strategy good to NEG preparation. The stability of the NEG was strongly influenced by storage temperature, with droplet size increasing rapidly at higher temperatures (45 °C), which was attributed to coalescence near the phase inversion temperature. The NEG submitted the low temperatures (4±2 °C) remained with the same particle size value (164 nm). However, the citronellol and geraniol showed a significant reduction throughout the test even in these conditions of temperature. Thermo gram of NEG shows the crystallization peak at the cooling cycle in-20.1 °C and a melting was observed at 1.5 °C. TEM images indicated that NEG was spherical and nanometric. Conclusion:The proposed Ultra-Turrax method is simple which prevents volatilization of GO for the production of NEG. The formulations presented good physicochemical characteristics and stability for 90 d was only achieved in 4 °C.

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“…The smaller particle size of geranium nanoemulsion efficiently penetrates biofilms and hence damages the organism's cell membrane. [ 79 ] Similarly, cinnamic acid derivatives showed great antibiofilm activity against C . albicans at lower MIC compared to fluconazole.…”

Section: Mechanism Of Action Of Anti-candida Natural Productsmentioning

confidence: 99%

Plants' natural products as alternative promising anti-Candida drugs

Soliman¹,

Alnajdy²,

El‐Keblawy³

et al. 2017

Phcog Rev

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Candida is a serious life-threatening pathogen, particularly with immunocompromised patients. Candida infections are considered as a major cause of morbidity and mortality in a broad range of immunocompromised patients. Candida infections are common in hospitalized patients and elderly people. The difficulty to eradicate Candida infections is owing to its unique switch between yeast and hyphae forms and more likely to biofilm formations that render resistance to antifungal therapy. Plants are known sources of natural medicines. Several plants show significant anti-Candida activities and some of them have lower minimum inhibitory concentration, making them promising candidates for anti-Candida therapy. However, none of these plant products is marketed for anti-Candida therapy because of lack of sufficient information about their efficacy, toxicity, and kinetics. This review revises major plants that have been tested for anti-Candida activities with recommendations for further use of some of these plants for more investigation and in vivo testing including the use of nanostructure lipid system.

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Anti- Candida activity assessment of Pelargonium graveolens oil free and nanoemulsion in biofilm formation in hospital medical supplies

Cited by 29 publications

References 41 publications

Resurrection of Nalidixic Acid: Evaluation of Water-Based Nanoformulations as Potential Nanomedicine

Resurrection of Nalidixic Acid: Evaluation of Water-Based Nanoformulations as Potential Nanomedicine

Development of Nanoemulsion Containing Pelargonium Graveolens Oil: Characterization and Stability Study

Plants' natural products as alternative promising anti-Candida drugs

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