Anti Cutaneous Aging Effect of Red Djulis (<em>Chenopodium formosanum</em>) Extract on Gene Expression of Human Dermal Fibroblast

Abstract

Red djulis (Chenopodium formosanum) is a native cereal plant in Taiwan; it contains abundant polyphenols, betalian and dietary fiber. The appearance of red djulis is bright red. Therefore, it is also called the &amp;ldquo;ruby of cereals&amp;rdquo;. The antioxidative activity of red djulis extract is well-understood. However, the antiaging function still remains unclear. This study examined the potential of red djulis extract for enhancing collagen secretion and preventing cutaneous aging using red djulis extracts. The red djulis extracts are comprised of an abundant active component that can effectively enhance the ability of collagen secretion of dermal fibroblasts, prevent the glycation of collagen and resist the damage of ultraviolet light exposure. After fibroblast treatment with red djulis extracts, TGM1, KRT1, KRT10 and SOD2 genes were up-regulated significantly by 2.3, 4.3, 4.4 and 27.3 times, respectively, compared to those of the control group. Additionally, it can increase COL1A2 gene expression by 43% and decrease MMP9 gene expression 33%. Therefore, it was demonstrated that red djulis extracts affect gene expressions related to the skin barrier, antioxidation and collagen. Moreover, we found positive effects on skin barrier integrity, endogenous antioxidant activity and skin collagen-preservation. The preparation of the red djulis extracts is environmental friendly and can promote the economic value of Chenopodium formosanum; thus, the proposed extract is suitable for applications in the development of food products, especially beverages, skin care and cosmetic products.

Antiproliferative Effect and Mediation of Apoptosis in Human Hepatoma HepG2 Cells Induced by Djulis Husk and Its Bioactive Compounds

“…Djulis ( Chenopodium formosanum ) is a native cereal plant in Taiwan. Djulis has been proved to show marked biological activities such as antioxidant potential [ 4 ], antihypertension [ 5 ], anti-adipogenesis [ 6 ], hepatoprotective activity [ 4 , 7 ], and anti-cutaneous aging effect [ 8 ]. Moreover, djulis contains valuable nutrients and bioactive compounds [ 5 ], which contribute to its biological activities [ 5 ].…”

Anti Cutaneous Aging Effect of Red Djulis (<em>Chenopodium formosanum</em>) Extract on Gene Expression of Human Dermal Fibroblast

“…Additionally, chronic sun exposure leads to marked degradation of skin collagen structure resulting in wrinkle formation in photo aged skin (extrinsic aging) [8]. Therefore, in addition to sun exposure prevention, novel and effective anti-aging ingredients for skin care have drawn a lot of attention [9,10].…”