Anti-HIV and anti-inflammatory action of iodine-lithium-α-dextrin is accompanied by the improved quality of life in AIDS patients

Mkhitaryan, Levon M.; Davtyan, Tigran K.; Gabrielyan, É. S.; Gevorkyan, Levon A.

doi:10.1504/ijbt.2007.014252

Cited by 11 publications

(8 citation statements)

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“…Pebisut is a biodegradable and not toxic natural glue that may be exert anti-inflammatory activity similar to other compounds of natural polymers [ 7 – 9 ]. Besides, Zn component in Pebisut formulation is an essential trace element that plays a crucial role as a cofactor in a number of enzymes and different cellular activities.…”

Section: Introductionmentioning

confidence: 99%

Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc

Moreno-Eutímio

Nieto-Velázquez

Espinosa-Monroy

et al. 2014

BioMed Research International

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Pebisut is a biological adhesive composed of naturally occurring carbohydrates combined with zinc oxide (ZnO) initially used as a coadjutant for healing of anastomoses. Likewise some works demonstrated that carbohydrate complexes exerts anti-inflammatory activity and it is widely known that ZnO modulate inflammation. However, the direct effects of Pebisut on isolated cells and acute inflammatory responses remained to be investigated. The present study evaluated anti-inflammatory effect of Pebisut using lipopolysaccharide (LPS) stimulated human mononuclear cells, chemotaxis, and cell infiltration in vivo in a murine model of peritonitis. Our data show that human cells treated with different dilutions of Pebisut release less IL-6, IL-1β, and IL-8 after LPS stimuli compared with the control treated cells. In addition, Pebisut lacked chemotactic activity in human mononuclear cells but was able to reduce chemotaxis towards CCL2, CCL5, and CXCL12 that are representative mononuclear cells chemoattractants. Finally, in a murine model of peritonitis, we found less number of macrophages (F4/80+) and T lymphocytes (CD3+) in peritoneal lavages from animals treated with Pebisut. Our results suggest that Pebisut has anti-inflammatory activity, which might have a beneficial effect during anastomoses healing or wounds associated with excessive inflammation.

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Section: Introductionmentioning

confidence: 99%

Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc

Moreno-Eutímio

Nieto-Velázquez

Espinosa-Monroy

et al. 2014

BioMed Research International

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“…A broad spectrum of antimicrobial applications, including anti HIV-infection, and the high therapeutic efficacy of iodinecontaining drugs justify the need of physicochemical and structural research on model iodine complex compounds [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Low toxicity and the possibility of parenteral and enteral introduction are observed only in the ''Armenicum'' drug and the newly developed anti-infectious drug (AP) [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The effect of the amphoteric properties of amino acids in the zwitterionic form on the structure of iodine complex compounds in aqueous solutions

Yuldasheva¹,

Zhidomirov

Leszczyński

et al. 2013

Journal of Molecular Structure

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“…Quite a number of iodine–polymer complexes with a broad spectrum of antimicrobic and antiviral action, including HIV infection, are well known. Among them there is “Armenicum,” the drug aimed at HIV infection treatment 1–3. The distinctive drug feature is that its active substance includes not only iodine‐containing polymeric complex, but also potassium and lithium halogenides.…”

Section: Introductionmentioning

confidence: 99%

Effect of organic ligands with conjugated π‐bonds on the structure of iodine–α‐dextrin complexes

Yuldasheva¹,

Zhidomirov

Il’in³

2012

Biotech and App Biochem

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Using X-ray data for iodine-α-dextrin complexes and the results of quantum chemical ab initio restricted Hartree-Fock/3-21G(**) level calculations, a model of drug active complex (AC) Armenicum with anti-HIV action was proposed. It was suggested that the drug AC contains molecular iodine allocated inside of α-dextrin helix and coordinated by lithium halogenides and a protein component of lymphocyte ribosomes. The electronic structure of I(2) in this complex differs from its characteristics in complexes with organic ligands or the free I(2) . In the considered ACs, the molecular iodine displays acceptor (donor) properties toward the α-dextrins (lithium halogenides). A mechanism of Armenicum anti-HIV action is suggested. Under the influence of molecular iodine-containing drug AC, the structure of HIV DNA is modified-it becomes more π-donor-active against proteins and peptide nucleotides of viral DNA form a stable complex with molecular iodine and lithium halogenides.

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Anti-HIV and anti-inflammatory action of iodine-lithium-α-dextrin is accompanied by the improved quality of life in AIDS patients

Cited by 11 publications

References 0 publications

Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc

Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc

The effect of the amphoteric properties of amino acids in the zwitterionic form on the structure of iodine complex compounds in aqueous solutions

Effect of organic ligands with conjugated π‐bonds on the structure of iodine–α‐dextrin complexes

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