Anti‐ige autoantibodies in systemic lupus erythematosus

Gruber, Barry L.; Kaufman, Lee D.; Marchese, Mary J.; Roth, William; Kaplan, Allen P.

doi:10.1002/art.1780310810

Cited by 44 publications

(35 citation statements)

References 27 publications

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“…In our own experience and in other reports [12][13][14]19], a correlation exists between the levels of IgG anti-IgE and serum IgE in patients with high titers of serum IgE. How ever, no correlation was detectable between the level of IgG with auto-anti-IgE activity and the severity of disease.…”

Section: Discussionsupporting

confidence: 62%

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Detection of IgG Subclasses with Anti-lgE Activity in Patients with Atopic Diseases

Carini

Fratazzi²

1992

Int Arch Allergy Immunol

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Significantly increased levels of IgG anti-IgE were seen in atopic patients as compared with controls. A correlation was observed between the levels of anti-IgE autoantibodies and serum IgE in the groups of atopic patients studied. No significant correlation was found between IgG anti-IgE levels and severity of the disease or between IgG subclasses with anti-IgE activity and clinical status. Analysis of IgG subclasses with anti-IgE activity showed that IgG1 and IgG4 were clearly factors in differentiating the atopies from the controls. IgG2 and IgG3 anti-IgE levels were not statistically significantly elevated. The lack of these autoantibodies may be explained by the presence of immune complexes or the lack of specificity of the monoclonal antibodies used in this study. These observations have not yet determined whether these autoantibodies and the isotypic selection and restriction observed play a role in the dysregulation of the immune response and in the evolution towards atopy.

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Section: Discussionsupporting

confidence: 62%

“…One can speculate from this that the immune complex IgEanti-IgE is responsible for underestimation of serum IgE [21]. Some authors [7,12] have also reported that anti-IgE can bind to IgE molecules on mast cells and basophils, re sulting in the release of chemical mediators.…”

Section: Discussionmentioning

confidence: 96%

Detection of IgG Subclasses with Anti-lgE Activity in Patients with Atopic Diseases

Carini

Fratazzi²

1992

Int Arch Allergy Immunol

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“…In RA patients anti-IgE autoantibodies were found [34,35]. Moreover, IgE in immune complexes was assumed to sensitize RA synovial mast cells [36]. …”

Section: Discussionmentioning

confidence: 99%

PTPN22 Polymorphism Presumably Plays a Role in the Genetic Background of Chronic Spontaneous Autoreactive Urticaria

Brzoza¹,

Grzeszczak

Rogala³

et al. 2012

Dermatology

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Background: The association of chronic urticaria (CU) with autoimmune disorders is relatively well proved. Protein tyrosine phosphatase-22 (PTPN22) is considered to be one of the strongest genetic factors for human autoimmunity. We decided to evaluate whether additional, non 1858C>T, PTPN22 variants are independent contributors to the risk of CU occurrence in the Polish population. Methods: A total of 91 CU patients with a positive result of autologous serum skin test and 100 healthy volunteers were enrolled in the study. The Urticaria Activity Score was used in disease intensity assessment. In all subjects rs3811021, rs1310182 and rs2488457 polymorphisms were genotyped. Results: We found a higher prevalence of –1123 C allele among CU patients. No differences in the allele and genotype distribution were found in the other analyzed polymorphisms. Haplotype construction of the three SNPs revealed statistically significant CU association of rs2488457C, rs1310182T and rs3811021T. Conclusions: Contrary to previous findings, the contribution of PTPN22 to disease susceptibility is suggested. We can speculate that CU is a genetically complex disease and that its occurrence needs multiple genetic and environmental risk factors.

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“…Additionally, some reports have shown increased IgE production in this disease and have associated SLE with allergy (3)(4)(5)(6)(7)(8). In addition, the occurrence of anti-IgE IgG autoantibodies has been demonstrated in SLE patients with articular involvement, lymphadenopathy and anti-DNA antibodies (9). The human Th2 immune response is mainly observed in atopy and in some parasitic diseases, being characterized by significant production of IL-4, IL-10 and IgE antibodies.…”

mentioning

confidence: 99%

Immunoglobulin E and systemic lupus erythematosus

Atta

Sousa

Carvalho

et al. 2004

Braz J Med Biol Res

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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by intense polyclonal production of autoantibodies and circulating immune complexes. Some reports have associated SLE with a Th2 immune response and allergy. In the present study 21 female patients with SLE were investigated for total IgE and IgE antibodies to dust house aeroallergens by an automated enzymelinked fluorescent assay, and were also evaluated for antinuclear IgE autoantibodies by a modified indirect immunofluorescence test using HEp-2 cells as antigen substrate. Additionally, immunocapture ELISA was used to investigate serum anti-IgE IgG autoantibodies. Serum IgE above 150 IU/ml, ranging from 152 to 609 IU/ml (median = 394 IU IgE/ml), was observed in 7 of 21 SLE patients (33%), 5 of them presenting proteinuria, urinary cellular casts and augmented production of anti-dsDNA antibodies. While only 2 of 21 SLE patients (9.5%) were positive for IgE antibodies to aeroallergens, all 10 patients with respiratory allergy (100%) from the atopic control group (3 males and 7 females), had these immunoglobulins. SLE patients and healthy controls presented similar anti-IgE IgG autoantibody titers (X = 0.37 ± 0.20 and 0.34 ± 0.18, respectively), differing from atopic controls (0.94 ± 0.26). Antinuclear IgE autoantibodies were detected in 17 of 21 (81%) sera from SLE patients, predominating the fine speckled pattern of fluorescence, that was also observed in IgG-ANA. Concluding, SLE patients can present increased IgE levels and antinuclear IgE autoantibodies without specific clinical signs of allergy or production of antiallergen IgE antibodies, excluding a possible association between SLE and allergy.

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Anti‐ige autoantibodies in systemic lupus erythematosus

Cited by 44 publications

References 27 publications

Detection of IgG Subclasses with Anti-lgE Activity in Patients with Atopic Diseases

Detection of IgG Subclasses with Anti-lgE Activity in Patients with Atopic Diseases

PTPN22 Polymorphism Presumably Plays a Role in the Genetic Background of Chronic Spontaneous Autoreactive Urticaria

Immunoglobulin E and systemic lupus erythematosus

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