Anti-inflammatory actions of tannins isolated from the bark of Anacardwm occidentale L

Thomas, Merlin C.; Filho, José Maria Barbosa

doi:10.1016/0378-8741(85)90074-1

Cited by 138 publications

(33 citation statements)

References 21 publications

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“…In Brazil, cashew fruits and their juice are used to treat fever, sweeten bread and conserve the stomach[2]. In Nigeria, the decoction of root and stem is used as antiinflammatory agent and antidiarrhoea[3]. …”

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confidence: 99%

“…Some tribes of Surinam use the seed oil of cashew as an external wormicide to kill butterfly larva. In Brazil, the tea of the bark is used as douche and as an astringent to stop bleeding after tooth extraction[3]. A wine made from the fruit is used for dysentery in other parts of Amazon.…”

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confidence: 99%

“…Its fruits were shown to exhibit antibacterial activity against Helicobacter pylori that is commonly implicated in acute gastritis and stomach ulcers[5]. The antidiabetic and antiinflammatory properties of the leaf and bark extracts of the cashew plant have also been validated[349]. The observed antiinflammatory and antidiarrhea activities of cashew extracts have been attributed to tannins.…”

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Sub-chronic hepatotoxicity of Anacardium occidentale (Anacardiaceae) inner stem bark extract in rats

Okonkwo¹,

Okorie²,

Okonta³

et al. 2010

Indian J Pharm Sci

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The extracts of Anacardium occidentale have been used in the management of different cardiovascular disorders in Nigeria. These have necessitated the assessment of the toxicity of this plant extract in sub-chronic administration. The inner stem bark of Anacardium occidentale was extracted with 80 % methanol and quantitatively analysed for antinutrients and some heavy metals. The phytochemical compositions and acute toxicity of the extract were determined also. Toxicity profiles of the extract on some liver function parameters were evaluated following a sub-chronic oral administration at doses of 1.44 and 2.87 g/kg. The phytochemical screening of extract revealed the presence of high amount of tannins, moderate saponins and trace of free reducing sugars. The antinutrient levels were 5.75 % (tannins), 2.50 % (oxalates), 2.00 % (saponins), 0.25 % (phytate) and 0.03 % (cyanide). The quantity of iron detected from dried crude was 8.92 mg/100 g, while lead and cadmium were non-detectable. The extract had LD50of 2.154g/kg p.o. in mice. Sub-chronic administration of the extract significantly increased the serum levels of alanine aminotransaminase and aspartate aminotransaminase, which are indicative of liver damage. The serum levels of alkaline phosphatase and total protein of the treated animals were not significantly increased. The effects of sub-chronically administered extract on hepatocytes were minimal as the serum alkaline phosphatase; total bilirubin and total protein levels in treated animals were not significant (p< 0.05). Thus, sub-chronic administrations of Anacardium occidentale inner stem bark extract did not significantly (p< 0.05) depress the function of hepatocytes in Wistar rats.

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Sub-chronic hepatotoxicity of Anacardium occidentale (Anacardiaceae) inner stem bark extract in rats

Okonkwo¹,

Okorie²,

Okonta³

et al. 2010

Indian J Pharm Sci

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“…A mixture of tannins (hydrolysable and non-hydrolysable) have been demonstrated to have apparent anti-inflammatory activity in carrageenan- and dextran-induced rat paw edema, cotton pellet granuloma test, and adjuvant-induced polyarthritis in rats. It is thought to be due to antagonism of the permeability-increasing effects of some inflammatory mediators, thus inhibiting the migration of leukocytes to an inflammatory site [31]. Anthraquinones were also found to possess anti-inflammatory activity after their inhibitory activities on NO production, COX-2, and PGE 2 which was determined in a lipopolysaccharide-induced inflammation model and in carrageenan-induced paw edema [32].…”

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confidence: 99%

Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freund's adjuvant-induced arthritis

Ben

Woode

Koffuor

et al. 2017

J Intercult Ethnopharmacol

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Aim:This study aimed to assess the effect of petroleum ether extract (PEE), ethyl acetate extract (EthE), and ethanol extract (EAE) of Trichilia monadelpha stem bark on bone histomorphology in arthritis.Methods:Percentage inhibition of edema and arthritic scores in complete Freund’s adjuvant-induced (0.1 ml of 5 mg/ml1 of heat-killed Mycobacterium tuberculosis in paraffin oil-injected subplantar into the right hind paw) arthritic Sprague-Dawley rats treated with PEE, EthE, or EAE (10,30, and 100 mg/kg1, respectively), dexamethasone (0.3-3.0 mg/kg1), or methotrexate (0.1-1.0 mg/kg1) over a 28-day period were estimated. Rat paws were radiographed and scored. Body weights were taken and paw tissues were harvested for histopathological studies.Results:The extracts significantly (P ≤ 0.01-0.0001) and dose dependently reduced the polyarthritic phase of arthritis. EAE and PEE significantly (P ≤ 0.01-0.0001) minimized edema spread from acute arthritic phase (days 0-10) to polyarthritic phase (days 10-28). EthE improved which deteriorated body weight in arthritis. All extracts significantly (P ≤ 0.05-0.01) improved arthritic score; reducing erythema, swelling and joint rigidity, and also significantly (P ≤ 0.05-0.01) reduced hyperplasia, pannus formation, and exudation of inflammatory cells into synovial spaces.Conclusion:The stem bark extracts of T. monadelpha reduce bone tissue damage and resorption associated with adjuvant-induced arthritis, hence could be useful in managing arthritis in humans.

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“…Previously, tannins and saponins isolated from medicinal plants exhibited analgesic and anti-inflammatory activities (Thomas et al, 1985;Owoyele et al, 2010;Choi et al, 2005). We thus suggested that the tannins and saponins present in C. vogelii extract were responsible for its analgesic and anti-inflammatory activities.…”

Section: Discussionmentioning

confidence: 99%

Analgesic and anti-inflammatory effects of Cyphostemma vogelii (Hook. f.) Desc. root extract in mice

Udegbunam¹,

Udegbunam²,

Anosa³

2013

Afr. J. Biotechnol.

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Cyphostemma vogelii (family: Vitaceae) is a herbaceous plant which grows in Obukpa town in SouthEastern Nigeria. C. vogelii is said to be generally medicinal though no specific medicinal activity was mentioned in the literature for this plant. The analgesic effect of C. vogelii was evaluated using acetic acid-induced writhing and formalin-induced nociception tests. The extract was also screened for antiinflammatory activity using carrageenan-induced and kaolin-carrageenan-induced paw edema tests. C. vogelii extract dose dependently inhibited acetic acid-induced pain in mice. The extract at 200 and 400 mg/kg significantly inhibited inflammatory and neurogenic pain induced by formalin. The effects of 200 mg/kg on formalin induced pain were similar to those of aspirin, while 400 mg/kg produced more inhibitory effects. At 2, 3 and 5 h post carrageenan injection, 200 and 400 mg/kg extract significantly inhibited paw edema. The extract dose dependently suppressed kaolin-carrageenan-induced edema from 3 h post treatment for up to 24 h. The effect of 400 mg/kg on kaolin-carrageenan-induced edema was similar to that of aspirin, while 100 mg/kg showed the least activity. The data obtained from this study showed that the methanol extract of C. vogelii exhibited mild analgesic activity as well as antiinflammatory activity.

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Anti-inflammatory actions of tannins isolated from the bark of Anacardwm occidentale L

Cited by 138 publications

References 21 publications

Sub-chronic hepatotoxicity of Anacardium occidentale (Anacardiaceae) inner stem bark extract in rats

Sub-chronic hepatotoxicity of Anacardium occidentale (Anacardiaceae) inner stem bark extract in rats

Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freund's adjuvant-induced arthritis

Analgesic and anti-inflammatory effects of Cyphostemma vogelii (Hook. f.) Desc. root extract in mice

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