Anti-inflammatory Activity of the Synthetic Chalcone Derivatives: Inhibition of Inducible Nitric Oxide Synthase-Catalyzed Nitric Oxide Production from Lipopolysaccharide-Treated RAW 264.7 Cells

Synthesis, inhibition of NO production and antiproliferative activities of some indole derivatives

“…Once activated by inflammatory stimulation, macrophages produce a large number of cytotoxic molecules. It is well characterized that treatment of RAW 264.7 macrophages with LPS (1 g/mL) for 24 h induces NO production (26.4 M from the basal level of 0.6 M) [32], as assessed by measuring the accumulation of nitrite, a stable metabolite of NO, in the media based on Griess reaction. The beneficial effect of coumarin derivatives on the inhibition of production of the inflammatory mediators in macrophages can be mediated through oxidative degradation of products of phagocytes, such as O 2-and HOCl.…”

Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway

“…Hence, we believe that this similarity of both compounds has contributed to the parallel inhibitory effects observed. A handful of studies have identified the anti-inflammatory properties in chalcones by which chalcones were able to inhibit NO production, iNOS expression and NF-κB activation [23][24][25]. Bearing these chalcone properties, cardamonin was suggested to affect cytokine expression in BV2 cells via suppression of NO production as NO stimulates the production of various inflammatory mediators including TNF-α and IL-1β [26].…”

Solvent Free Synthesis of Chalcone as Antibacterial Substance

“…Beberapa senyawa calkon yang berhasil diisolasi menunjukkan aktivitas biologis yang sangat bermanfaat, antara lain sebagai antitumor, antiinflamasi, antimikroba dan tabir surya (Achanta et al, 2006;Kim et al, 2007;Kim et al, 2008;Prasad et al, 2008). Begitu pula Jasril et al, (2012) berhasil mensintesis senyawa bromocalkonpiridin dan menunjukkan aktivitasnya sebagai antibakteri.…”