Anti-inflammatory effects of Morchella esculenta polysaccharide and its derivatives in fine particulate matter-treated NR8383 cells

Li, Wan; Cai, Zheng-Nan; Mehmood, Shomaila; Liang, Lin-Lin; Liu, Yu; Zhang, Huiyun; Chen, Yan; Lu, Yongming

doi:10.1016/j.ijbiomac.2019.02.088

Cited by 33 publications

(16 citation statements)

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“…As previously reported, ME polysaccharides and proteins can increase antioxidant enzyme activity and improve immune system function [14, 34]. M. esculenta polysaccharide protects NR8383 cells from PM2.5-induced inflammation by inhibiting NF- κ B activation [16], and total flavonoids of M. esculenta have anti-inflammatory effects through lipopolysaccharide-stimulated RAW264.7 macrophages [17]. These nutritional components provide a foundation for understanding the hepatoprotective effects of ME in the treatment of alcohol-induced acute liver injury.…”

Section: Discussionmentioning

confidence: 92%

“…Morchella esculenta , which contains various nutrients, has a variety of pharmacological activities including antioxidative, anti-inflammatory, and antitumor effects [13, 14]. A heteropolysaccharide isolated from the fruiting bodies of M. esculenta can effectively scavenge hydroxyl and superoxide radicals [15] and exert anti-inflammatory effects via blocking the activation of NF- κ B signaling [16]. Meanwhile, the total flavones of a fermentation broth resulting from coculture of M. esculenta and Coprinus comatus showed an anti-inflammatory effect on lipopolysaccharide-stimulated RAW264.7 macrophages via the mitogen-activated protein kinase (MAPK) signaling pathway [17].…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective Effects ofMorchella esculentaagainst Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling

Meng

Zhang

Wang

et al. 2019

Oxidative Medicine and Cellular Longevity

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This study investigated the hepatoprotective effects of Morchella esculenta fruit body (ME) and the underlying mechanisms in mice with alcohol-induced acute liver injury. Systematic analysis revealed that ME contained 21 types of fatty acid, 17 types of amino acid, and 12 types of mineral. Subsequently, a mouse model of acute alcohol-induced liver injury was established by oral administration of alcohol for 14 days. Fourteen-day administration of ME prevented alcohol-induced increases in alanine aminotransferase and aspartate aminotransferase levels and reduced the activity of acetaldehyde dehydrogenase in blood serum and liver tissue. ME appears to regulate lipid metabolism by suppressing triglycerides, total cholesterol, and high-density lipoprotein in the liver. ME inhibited the production of inflammatory factors including chitinase-3-like protein 1 (YKL 40), interleukin-7 (IL-7), plasminogen activator inhibitor type 1 (PAI-1), and retinol-binding protein 4 (RBP4) in blood serum and/or liver tissue. ME treatment relieved the alcohol-induced imbalance in prooxidative and antioxidative signaling via nuclear factor-erythroid 2-related factor 2 (Nrf-2), as indicated by upregulation of superoxide dismutase-1, superoxide dismutase-2, catalase, heme oxygenase-1, and heme oxygenase-2 expression and downregulation of kelch-like ECH-associated protein 1 (Keap-1) in the liver. Moreover, ME reduced the levels of phosphorylated nuclear factor kappa-B kinase α/β, inhibitor of nuclear factor kappa-B α and nuclear factor kappa-B p65 (NF-κB p65) in the liver. The hepatoprotective effects of ME against alcohol-induced acute liver injury were thus confirmed. The mechanism of action may be related to modulation of antioxidative and anti-inflammatory signaling pathways, partially via regulation of Nrf-2 and NF-κB signaling.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects ofMorchella esculentaagainst Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling

Meng

Zhang

Wang

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…In Ascomycotina Discomycetes Pezizales Morchellaceae EMPs polysaccharides, Mw is substantially in the range in the range of 6.9–192 kDa [ 39 , 40 , [97] , [98] , [99] , [100] , [101] , [102] , [103] , [104] , [105] ]. Based on Tables 1 and S2, there is no directly antiviral ability in Morchellaceae polysaccharides, and more is the ability to increase the immunity of indirect anti-virus.…”

Section: Types and Structural Characteristics Of Emfs Antiviral Polysaccharidesmentioning

confidence: 99%

“…Based on Tables 1 and S2, there is no directly antiviral ability in Morchellaceae polysaccharides, and more is the ability to increase the immunity of indirect anti-virus. Besides that, there are some anti-inflammatory polysaccharides in Morehella esculenta , such as EMP-1, SEMP-1, PEMP, Ac-PMEP1-3 [ 97 , 99 ], which may be related to the sulfate and acetylation of morel polysaccharides.…”

Section: Types and Structural Characteristics Of Emfs Antiviral Polysaccharidesmentioning

confidence: 99%

“…Morchella esculenta polysaccharide (EMP-1) and sulfated polysaccharide (SEMP-1) were found that the best-protecting effect in decreasing PM2.5-induced cell death, cell apoptosis and production of TNF-α and IL-1β, as well as accompanied by a vitiated level in ROS formation, caused by PM2.5 in rat alveolar macrophage NR8383 cells [ 99 ]. Moreover, SEMP-1 could decrease the expression of iNOS and COX-2 at both mRNA and protein levels with PM2.5 treatment.…”

Section: Antiviral Mechanisms Of Emfs Polysaccharidesmentioning

confidence: 99%

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Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Guo

Chen

Gong

2021

International Journal of Biological Macromolecules

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The deficiency of chemical-synthesized antiviral drugs when applied in clinical therapy, such as drug resistance, and the lack of effective antiviral drugs to treat some newly emerging virus infections, such as COVID-19, promote the demand of novelty and safety anti-virus drug candidate from natural functional ingredient. Numerous studies have shown that some polysaccharides sourcing from edible and medicinal fungus (EMFs) exert direct or indirect anti-viral capacities. However, the internal connection of fungus type, polysaccharides structural characteristics, action mechanism was still unclear. Herein, our review focus on the two aspects, on the one hand, we discussed the type of anti-viral EMFs and the structural characteristics of polysaccharides to clarify the structure-activity relationship, on the other hand, the directly or indirectly antiviral mechanism of EMFs polysaccharides, including virus function suppression, immune-modulatory activity, anti-inflammatory activity, regulation of population balance of gut microbiota have been concluded to provide a comprehensive theory basis for better clinical utilization of EMFs polysaccharides as anti-viral agents.

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α_2A‐AR antagonism by BRL‐44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway

Cong

Tao

et al. 2020

Journal Cellular Physiology

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Acute respiratory distress syndrome (ARDS), characterized by acute hypoxic respiratory dysfunction or failure, is a manifestation of multiple organ failure in the lung, and the most common risk factor is sepsis. We previously showed that blocking α 2 -adrenoceptor (α 2 -AR) could attenuate lung injury induced by endotoxin in rats.α 2A -adrenoceptor (α 2A -AR), a subtype of α 2 -AR plays a key role in inflammatory diseases, but the mechanism remains unknown. Here, we explored the effect of BRL-44408 maleate (BRL), a specific α 2A -AR antagonist, on cecal ligation puncture (CLP)-induced ARDS in rats and the underlying mechanism. Preadministration of BRL-44408 maleate significantly alleviated CLP-induced histological injury, macrophage infiltration, inflammatory response, and wet/dry ratio in lung tissue. However, there was no statistical difference in survival rate between the CLP and CLP+BRL groups. Extracellular regulated protein kinase (ERK1/2), p38MAPK, and p65 were activated in the CLP group, and BRL-44408 maleate inhibited the activation of these signal molecules, c-Jun N-terminal kinase (JNK) and protein kinase A (PKA) showed no changes in activation between these two groups. BRL-44408 maleate decreased lipopolysaccharide (LPS)-induced expression of cytokines in NR8383 rat alveolar macrophages and reduced phosphorylation of ERK1/2, p38MAPK, and p65. JNK and PKA were not influenced by LPS. Together, these findings suggest that antagonism of α 2A -AR improves CLP-induced acute lung injury and involves the downregulation of ERK1/2, p38MAPK, and p65 pathway independent of the activation of JNK and PKA. K E Y W O R D S acute respiratory distress syndrome, BRL-44408 maleate, MAPK and NF-κB, protein kinase A, α 2A -AR 1 | INTRODUCTION Acute respiratory distress syndrome (ARDS), which is characterised by acute hypoxic respiratory dysfunction or failure with bilateral pulmonary infiltration, is a manifestation of multiple organ failure in the lung, often caused by various noncardiac reasons, either direct or indirect pulmonary injury, including severe pneumonia, aspiration of gastric contents, severe trauma, infection, shock, and sepsis (Williams et al., 2017). Because of the improvements in critical care practice, including lung-protective ventilation, timely resuscitation, and antimicrobial administration, restrictive transfusion strategies, the incidence of ARDS has a substantial decline (

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Anti-inflammatory effects of Morchella esculenta polysaccharide and its derivatives in fine particulate matter-treated NR8383 cells

Cited by 33 publications

References 45 publications

Hepatoprotective Effects ofMorchella esculentaagainst Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling

Hepatoprotective Effects ofMorchella esculentaagainst Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

α_2A‐AR antagonism by BRL‐44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway

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Anti-inflammatory effects of Morchella esculenta polysaccharide and its derivatives in fine particulate matter-treated NR8383 cells

Cited by 33 publications

References 45 publications

Hepatoprotective Effects ofMorchella esculentaagainst Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling

Hepatoprotective Effects ofMorchella esculentaagainst Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

α2A‐AR antagonism by BRL‐44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway

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Product

Resources

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α_2A‐AR antagonism by BRL‐44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway