Anti-inflammatory effects of the extract of indigo naturalis in human neutrophils

Lin, Yin-Ku; Leu, Yann‐Lii; Huang, Tse-Hung; Wu, Yi‐Hsiu; Chung, Pei-Jen; Pang, Jong‐Hwei S.; Hwang, Tsong‐Long

doi:10.1016/j.jep.2009.06.014

Cited by 82 publications

(50 citation statements)

References 38 publications

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“…eczema, aphthae, skin eruptions, mumps, erysipelas, herpes zoster, carbuncles and furuncles. Yet, because of its poor solubility in water and poor absorption, its use is limited [9,11,12]. Indigo naturalis' ability to modify the proliferation and differentiation of keratinocytes explains its application in the treatment of psoriatic patients.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

“…Indigo naturalis' ability to modify the proliferation and differentiation of keratinocytes explains its application in the treatment of psoriatic patients. Moreover, it is thought to exert an anti-inflammatory effect and induce apoptosis [9,12]. Immunohistochemical studies conducted by Lin et al [9], who investigated the effect of Indigo naturalis on human psoriatic skin lesions, suggest that this herb effectively decreases the level of proliferating cell nuclear antigen, and increases the level of involucrin, a known differentiation marker.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

“…Thus, this sort of treatment may restore the physiological balance in the epidermis. Moreover, indirubin has been shown to inhibit the production of interferon-g, interleukin-6 and RANTES chemokine, also involved in the pathogenesis of psoriasis [12].…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

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Traditional Chinese medicine herbs — are they safe for psoriatic patients?

Bartosińska

Pietrzak²,

Szepietowski³

et al. 2011

Folia Histochem Cytobiol.

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Abstract: Abstract: Abstract: Although traditional Chinese medicine (TCM) relies on remedies of natural origin, its use is not always safe as it can have not only beneficial but also deleterious effects. Psoriatic patients, disappointed by conventional treatment and unaware of the potential side effects of TCM preparations, are increasingly reaching for non-traditional therapeutic methods. This review presents brief characteristics of selected Chinese herbs self-prescribed by psoriatic patients. It is important that dermatologists should be able to recognize any potential hazards connected with current or previous taking of these herbs by their patients. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 2, 201-205) Key words: Key words: Key words: Key words: Key words: traditional Chinese medicine, Chinese herbs, herbal medicine, psoriasis, adverse reaction Therefore, observing no immediate results, many patients become discouraged or frustrated and start looking for alternative means of treatment. Traditional Chinese medicine (TCM) is one option. However, the assumption that herbal preparations used in TCM, known as Chinese materia medica (CMM), are safe for human use (because of their natural origin), is a common misconception [1][2][3]. According to TCM proponents, this kind of treatment typically involves the application of herbs and vitamins as well as the use of a wide range of therapeutic methods, such as massages, acupuncture, diet and lifestyle modification [3].This paper attempts a short study of the characteristics of Chinese herbs available on the market and frequently found in herbal therapeutic mixtures. P P P P Pros and cons of TCM ros and cons of TCM ros and cons of TCM ros and cons of TCM ros and cons of TCM CMMs are believed to have a positive influence on various pathogenic mechanisms observed in pso-

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Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

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Traditional Chinese medicine herbs — are they safe for psoriatic patients?

Bartosińska

Pietrzak²,

Szepietowski³

et al. 2011

Folia Histochem Cytobiol.

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“…, 항암 6,7) , 아나필락시 알러지 반응 억제 8) 와 항 HIV-1 9) , 항염증 10 Normal, No treated group; Control, DNCB only group; 1X, DNCB+1% PTN group; 5X, DNCB+5% PTN group. Significant differences were compared with normal at ###p＜0.001 or control ＊**p＜0.001.…”

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confidence: 99%

The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in DNCB-Induced Hairless Mice

Choo¹,

Park²,

Jeong³

et al. 2014

Herbal Formula Science

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Objectives : The purpose of this study was to investigate the effects of Polygonum tinctoria Niram(PTN) on atopic dermatitis(AD) in hairless mice induced by 2,4-dinitrochlorobenzene(DNCB).Method : They were divided into four group, Nor, Con, 1X and 5X, for evaluating the change of appearance of skin surface, skin hydration, thickness of epidermis and mast cell numbers during 30 days.Results : PTN suppressed symptoms of AD in appearance of skin and increased skin hydration for 1X and 5X. In histopathological examination, 1X and 5X significantly reduced the thickness of epidermis and number of mast cell in dermis. These results suggested that the PTN improved the AD-like symptoms of hairless Mice.

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“…이와 같은 쪽의 화학 적 특성 때문에 색소를 침전시켜 남(藍)을 만든 후 저장하 면서 필요할 때 발효하여 사용하는 염색방법이 우리나라에 서 주로 이용되는 방법이다. 쪽 염색물은 세탁, 일광에 비교 적 강한 견뢰도를 지니고 있으며 (Park et al, 2011), 염색제 품을 비롯하여 비누, 화장품류, 차, 건강보조제, 치약, 미백 제, 피부자극 완화제, 의약품 등 다양하게 이용되기도 하며, 항균, 항암, 혈압강화 작용, 피임 작용, 간 보호 작용, 진경 작용, 항산화 작용 등 여러 가지 생리기능을 갖는 것으로 알 려져 있다 (Han & Choi, 2000;Seo, 2008;Heo, 2009;Lin et al, 2009).…”

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Changes of Fresh Leaf Yield and Colorant Level with Different Transplanting and Harvest Time in Persicaria tinctoria H. Gross

고재형¹,

김성주²,

이후관³

et al. 2013

Korean Journal of Crop Science

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This study was conducted to determinate the optimum times of transplanting and harvest for enhancing the fresh leaf yield and colorant level of an indigo crop, Persicaria tinctoria H. Gross, containing the blue dye indigo. Two cultivars, Naju Local and a new cultivar, NaramBlue, were transplanted 5 times from May 30 to July 10 at an interval of 10 days, and all of experiment plots harvested on Aug. 23 in Muan, the south area of Korea. As transplanting time was delayed, fresh leaf yield were maximum at earliest transplanting (May 30) and then decreased, while Niram (blue dye extract) and indigo content of fresh leaf remained almost constant though showed a small variation. Also, two cultivars transplanted on May 23 were harvested 5 times from Jul. 20 to Sept. 20 at an interval of 15 days. As harvest time was delayed, plant height, No. of first branches, and fresh leaf yield changed increasingly, while Niram content was increased to Aug. 20 and then decreased slightly. Indigo level increased largely to Aug. 5, and then continuously decreased with more delayed harvest. These tendencies of changes in fresh leaf yield and colorant level with different transplanting and harvest times were shown similarly in both cultivars. The results indicate that early transplanting before May 30 and harvest in early August will be appropriate for improving fresh leaf yield and colorant level.

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Anti-inflammatory effects of the extract of indigo naturalis in human neutrophils

Cited by 82 publications

References 38 publications

Traditional Chinese medicine herbs — are they safe for psoriatic patients?

Traditional Chinese medicine herbs — are they safe for psoriatic patients?

The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in DNCB-Induced Hairless Mice

Changes of Fresh Leaf Yield and Colorant Level with Different Transplanting and Harvest Time in Persicaria tinctoria H. Gross

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Anti-inflammatory effects of the extract of indigo naturalis in human neutrophils

Cited by 82 publications

References 38 publications

Traditional Chinese medicine herbs &#8212; are they safe for psoriatic patients?

Traditional Chinese medicine herbs &#8212; are they safe for psoriatic patients?

The Effect of the Polygonum tinctoria Niram on Atopic Dermatitis in DNCB-Induced Hairless Mice

Changes of Fresh Leaf Yield and Colorant Level with Different Transplanting and Harvest Time in Persicaria tinctoria H. Gross

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Traditional Chinese medicine herbs — are they safe for psoriatic patients?

Traditional Chinese medicine herbs — are they safe for psoriatic patients?