Anti-inflammatory of Purple Roselle Extract in Diabetic Rats Induced by Streptozotocin

Mardiah,; Zakaria, Fransiska Rungkat; Prangdimurti, Endang; Damanik, Rizal

doi:10.1016/j.profoo.2015.01.020

Cited by 27 publications

(17 citation statements)

References 13 publications

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“…This result almost similar to previous research that mentioned the effective dose in lowering blood glucose levels of mice induced by Streptozocin is 288 mg Rosella flower extract [16].…”

supporting

confidence: 92%

Rosella Flower Decreases the CML Serum and Liver Inflammation of Rats Given Baked-Food Diet

Falyani

Soeharto

Widjajanto

et al. 2016

JELS

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Advanced Glycation Endproducts (AGEs) or so-called glycotoxin can be triggered by heated food in which the Maillard reaction occurs. One type of glycotoxins is CML. Accumulated N-Carboxymethyl-Lysine (CML) can cause inflammation of organs, e.g. liver. Rosella flowers contain anthocyanin compound that has anti-glycation and antioxidant effects. This study aimed to determine the effect of ethanol extract of Rosella on CML serum level, IL-6 level, and NF-ƙB activation in the liver of mice fed with baked food. This study used post-test design using 25 Wistar rats aged 3-4 months old that were divided into 5 groups, namely negative control group, positive control group, treatment groups given Rosella extract dose of 200mg.kgBW . Baked feed was given for 12 weeks, and Rosella ethanol extract was administered in the 9 th to 12 th week. The examination on CML serum and IL-6 of the liver was using ELISA method. Immunofluorescent staining was used to determine NF-ƙB activation in the liver using a confocal microscope. CML serum is proven to increase significantly (p = 0.000). The effective dose of Rosella flower extract to prevent CML Serum increase is 200 mg.kgBW, whereas a dose of 400 mg.kgBW -1 can decrease IL-6 level and NF-ƙB activation. Ethanol extract of Rosella flower decrease the levels of N-carboxymethyl-lysine serum, IL-6, and NF-ƙB activation in the liver of rats given baked-food diet.

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“…This result almost similar to previous research that mentioned the effective dose in lowering blood glucose levels of mice induced by Streptozocin is 288 mg Rosella flower extract [16].…”

supporting

confidence: 92%

Rosella Flower Decreases the CML Serum and Liver Inflammation of Rats Given Baked-Food Diet

Falyani

Soeharto

Widjajanto

et al. 2016

JELS

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“…Several groups of compounds in the extract, such as anthocyanins and protocatechuic acid, have been implicated as responsible for these effects (Da-Costa-Rocha et al, 2014). Hibiscus extract also demonstrated antibacterial, antifungal, antiparasitic, anti-inflammatory and antioxidant effect (Al-Hashimi, 2012;Mardiah et al, 2015). Protocatechuic acid compound in extract inhibited the growth of methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii (Liu et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Aging in Yeast Saccharomyces cerevisiae by Roselle Petal Extract (Hibiscus sabdariffa L.)

Sarima

Astuti

Meryandini

2019

American Journal of Biochemistry and Biotechnology

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Cellular aging drives diseases. Free radicals are called the main cause of cellular aging. Antioxidants can protect the body from free radical attack by reducing its negative effects. An antioxidant source can be obtained from plants, such as roselle (Hibiscus sabdariffa. L). This research was conducted to analyze the ability of roselle petals extract to increase the life span of model organisms Saccharomyces cerevisiae BY4741. The IC 50 value of extract-derived antioxidant activity based on DPPH and ABTS assays were 367,6 ppm and 921,4 ppm, respectively. Antioxidant and antiaging tests were performed in vivo via spot assay. The result showed that the roselle petals extract-treated groups had the ability to extend the life span of yeast BY4741 under normal and oxidative stress conditions. This is also supported by the mitochondrial activity of BY4741 with roselle petals extract-treated group higher than those without the extract treatment. The 300 ppm concentration was chosen as the best concentration of roselle petals extract to increase the life span in yeast. Interestingly, important gene to regulate aging in yeast (SIR2) as well as oxidative stress response genes (GPX1 and GLR1) were significantly up-regulated in yeast cells treated with 300 ppm roselle extract, as revealed via Real-time quantitative analysis. These results suggest that roselle petals extract exhibits antiaging effects likely via regulation of anti-oxidative stress and aging genes.

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“…Antioksidan dalam pangan diartikan sebagai enzim atau senyawa organik dalam pangan yang secara signifikan dapat meredam efek negatif dari reaktif oksigen spesies dan reaktif nitrogen spesies dalam tubuh. Senyawa yang memiliki sifat sebagai antioksidan dilaporkan dapat menurunkan tingkat radikal bebas, tingkat penurunan dari TNF-α d berkontribusi untuk mencegah berbagai penyakit kronis seperti kanker, kardiovaskular, dan diabetes (Mustafa et al, 2010;Mardiah et al, 2015). Aktivitas antioksidan pada penelitian ini ditunjukkan dengan nilai IC 50 yang menyatakan nilai konsentrasi sampel yang dapat menurunkan aktivitas DPPH sebanyak 50%.…”

Section: Aktivitas Antioksidanunclassified

Pengaruh Perbedaan Waktu Panen Terhadap Karakteristik Kimia Biji Kecipir

Setiawan

Zakaria

Sitanggang

et al. 2019

jtip

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Anti-inflammatory of Purple Roselle Extract in Diabetic Rats Induced by Streptozotocin

Cited by 27 publications

References 13 publications

Rosella Flower Decreases the CML Serum and Liver Inflammation of Rats Given Baked-Food Diet

Rosella Flower Decreases the CML Serum and Liver Inflammation of Rats Given Baked-Food Diet

Modulation of Aging in Yeast Saccharomyces cerevisiae by Roselle Petal Extract (Hibiscus sabdariffa L.)

Pengaruh Perbedaan Waktu Panen Terhadap Karakteristik Kimia Biji Kecipir

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