Anti-Lipid Peroxidation Activities of Three Selected Fruits Juices Against Cadmium Induced Liver Damage In Vitro

Suhartono, Eko; Nijka, June Astri; Anhar, Vini Yulia; Sari, Rizki Amalia; Edyson, Edyson; Marisa, Dona

doi:10.11594/jtls.05.02.03

Cited by 9 publications

(4 citation statements)

References 21 publications

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“…Suhartono et al [7] result study showed that subacute and subchronic Cd exposure could increase the level of malondialdehyde (MDA) and advanced oxidation protein products (AOPPs) in kidney homogenates. Furthermore, our several results study showed that Cd exposure could induced oxidative stress, lipid peroxidation, and depletes the enzymatic antioxidant activity in brain, liver, and kidney of rats [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Anti-Metalotoxic Properties of Kelakai (Stenochlaena Palustris) Leaves Extract Against Cadmium-Induced Liver Tissue Damage

Biworo

Azizi

Padelia

et al. 2018

Asian J Pharm Clin Res

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Objective: The present study was undertaken to investigate the anti-metalotoxic activity of the leaves extract of Stenochlaena palustris (kelakai; S. palsutris) on cadmium (Cd)-induced liver tissue damage.Methods: Liver tissue damage was induced by the administration of cadmium sulfate (CdSO4) at a dose 3 mg/l. Anti-metalotoxic effect of the extracts was determined by assessing the concentration of malondialdehyde (MDA), carbonyl compound (CC), conjugated dienes (CD), and advanced oxidation protein products (AOPPs) induced by Cd with and without the presence of the extract.Results: The results of this present studies showed that treatment with CdSO4 significantly increase the levels of MDA, CC, CD, and AOPPs. The leaves extract of S. palustris significantly decrease the levels of all measured parameter in liver tissue.Conclusion: The present study demonstrated that Cd could induced the liver tissue damage, and the extract of S. palsutris showed the anti-metalotoxic activity to reduce the damage.

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Section: Introductionmentioning

confidence: 99%

Anti-Metalotoxic Properties of Kelakai (Stenochlaena Palustris) Leaves Extract Against Cadmium-Induced Liver Tissue Damage

Biworo

Azizi

Padelia

et al. 2018

Asian J Pharm Clin Res

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“…(10) AOPPs is known as a cross-linking protein products which are formed by a modification of amino acid caused by oxidation by a ROS. (22)(23)…”

Section: Discussionmentioning

confidence: 99%

UV-Visible Spectrophotometric as a Prospective Tool in Neonatal Sepsis

Suhartono¹,

Yunanto²,

Hartoyo³

et al. 2018

Indones Biomed J

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BACKGROUND: This study was aimed to employ the UV-Visible (UV-Vis) spectrophotometry techniques to detect the changes in the blood of neonatal sepsis (NS) subject for a deeper understanding in the pathomechanism of NS.METHODS: The cross-sectional study was conducted from February to May 2017 in the Neonatology Division, Department of Pediatric, Ulin General Hospital/Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia. Blood specimens were taken from newborns, of which 15 each of newborns at risk of sepsis and without risk of sepsis. Data were analyzed by using Mann-Whitney U test.RESULTS: The result of this study suggested that there is a significant difference in the average of absorbance ratio parameter using UV-Vis spectrophotometric methods on the case group compared to the control group. Also, there is a significant difference between advanced oxidation protein products (AOPPs) and thiocyanate (SCN) level in newborn at risk of sepsis.CONCLUSION: The present study demonstrated there were significant differences between the average of absorbance ratio parameter for protein and oxy-hemoglobin region using UV-Vis spectrophotometric methods in healthy subjects and newborn at risk of sepsis.KEYWORDS: spectrophotometric, neonatal sepsis, oxidative stress

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“…Sampling Procedure 30 cases of children (16 males and 14 females) aged upto 16 years, having clinical features of DHF as per World Health Organization (WHO), 1997 guidelines for control and prevention of DHF with positive serology were included in this study. 12 Dengue infection was confirmed by IgM/IgG and NS-1 detection. Another 30 age-and gender-matched children attending the Outpatient Department of General Paediatrics for routine check-up were included to serve as controls following simple random sampling method, of which 18 were males and 12 were females.…”

Section: Study Periodmentioning

confidence: 92%

Significance of Plasma Antioxidants in Pathogenesis of Dengue Haemorrhagic Fever

Singh¹,

Singh²

2018

jemds

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BACKGROUND Dengue is a major cause of morbidity in tropical and subtropical regions. It has been shown that there is a relationship between immune and oxidative mechanisms leading to altered immune responses. The role of free radicals in the pathogenesis of dengue fever in children is lacking. Aim-This study was done with the objective of determining various oxidants and antioxidants and evaluating their role in pathogenesis of severe form of Dengue Fever, Dengue Haemorrhagic Fever. MATERIALS AND METHODS 30 patients with Dengue Haemorrhagic Fever (DHF) in the age group of 0-16 years, having clinical features of DHF and positive findings in blood test were included in this study. Another 30 age and gender-matched children were included in this study to serve as controls. Levels of plasma MDA, protein carbonyl, nitrite, H2O2 and MPO activity were estimated by different standard methods. Statistical analysis was done with the help of t-test. Settings-This study was done in Mayo Institute of Medical Sciences, Lucknow. Design-A prospective, institution-based study. RESULTS The mean age of presentation of children with DHF was comparable to control values. The mean plasma levels of MDA, protein carbonyl, nitrite, Cu, H2O2 and MPO activity were significantly higher in patients with DHF as compared to control values (p < 0.05 each). CONCLUSION It can be concluded that imbalances between prooxidants and antioxidants play a significant role in pathogenesis of children with DHF.

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Anti-Lipid Peroxidation Activities of Three Selected Fruits Juices Against Cadmium Induced Liver Damage In Vitro

Cited by 9 publications

References 21 publications

Anti-Metalotoxic Properties of Kelakai (Stenochlaena Palustris) Leaves Extract Against Cadmium-Induced Liver Tissue Damage

Anti-Metalotoxic Properties of Kelakai (Stenochlaena Palustris) Leaves Extract Against Cadmium-Induced Liver Tissue Damage

UV-Visible Spectrophotometric as a Prospective Tool in Neonatal Sepsis

Significance of Plasma Antioxidants in Pathogenesis of Dengue Haemorrhagic Fever

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