Anti-obesity Effect of Hypsizigus marmoreus in High Fat-fed Mice

류해정,; 엄민영,; 안지윤,; 정창화,; 허담,; 김태완,; 하태열,

doi:10.3746/jkfn.2011.40.12.1708

Cited by 10 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, the size of epididymal adipose tissue fat cells increases significantly when obesity is induced by the intake of a high-fat diet [ 38 ]. Ryu et al (2011) [ 39 ] reported that the high-fat diet group increased the size of adipocytes compared to the normal group, and the group fed with white beech mushroom ( Hypsizigus marmoreus ) powder decreased the size of adipocytes, thereby inhibiting fat accumulation in adipose tissue. In our study, the adipocytes of the mice in the control group, which were administered a high-fat diet, were larger and irregularly shaped, compared to those of the normal group in the same ×40 magnification ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

Lactobacillus fermentum SMFM2017-NK4 Isolated from Kimchi Can Prevent Obesity by Inhibiting Fat Accumulation

Kim

Choi

Kim

et al. 2021

Foods

View full text Add to dashboard Cite

This study evaluated the anti-obesity effects of lactic acid bacteria. Thirty-one lactic acid bacteria were examined in vitro for their ability to inhibit α-glucosidase activity, lipase activity, and 3T3-L1 cell differentiation. Four selected lactic acid bacteria were administered to obese C57BL/6J mice models for 8 weeks. The degree of improvement in obesity was determined by weight gain and serum biochemical analysis. The expression levels of genes (Fas and Cpt-2) related to obesity in the liver were analyzed by quantitative reverse transcription (qRT)-PCR. In addition, antioxidant protein levels (SOD-2, CAT, and GPx-1) in the liver were evaluated. The lactic acid bacteria-treated groups (PPGK1, LFNK3, LPNK2, and LFNK4) showed lower weight increase rate than the control group. The total cholesterol (T-chol), triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in the blood serum of the LFNK4 group were the lowest among other groups, compared to the control group. The expression levels of lipid metabolism-related genes (Fas and Cpt-2) in the liver of the LFNK4 group were lower in Fas and higher in Cpt-2 than in the control group. The antioxidant protein expression levels (SOD-2, CAT, and GPx-1) in the liver tissue were also higher in the LFNK4 group. These results indicate that L. fermentum SMFM2017-NK4 has anti-obesity effects.

show abstract

Section: Resultsmentioning

confidence: 99%

Lactobacillus fermentum SMFM2017-NK4 Isolated from Kimchi Can Prevent Obesity by Inhibiting Fat Accumulation

Kim

Choi

Kim

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…Adipogenesis is controlled by the expression of specific adipogenic proteins that play an important role in fat accumulation in the adipocyte. Among the adipogenic proteins, SREBP-1, PPAR-γ, and C/EBP-α are crucial to adipocyte differentiation and fatty acid synthesis in adipocytes [ 63 , 64 , 65 ]. The function of FABP4 is the transportation of fatty acids between the extracellular matrix and intracellular matrix [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Ethanol Extracts from Grateloupia elliptica, a Red Seaweed, and Its Chlorophyll Derivative on 3T3-L1 Adipocytes: Suppression of Lipid Accumulation through Downregulation of Adipogenic Protein Expression

Lee

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

Grateloupia elliptica (G. elliptica) is a red seaweed with antioxidant, antidiabetic, anticancer, anti-inflammatory, and anticoagulant activities. However, the anti-obesity activity of G. elliptica has not been fully investigated. Therefore, the effect of G. elliptica ethanol extract on the suppression of intracellular lipid accumulation in 3T3-L1 cells by Oil Red O staining (ORO) was evaluated. Among the eight red seaweeds tested, G. elliptica 60% ethanol extract (GEE) exhibited the highest inhibition of lipid accumulation. GEE was the only extract to successfully suppress lipid accumulation among ethanol extracts from eight red seaweeds. In this study, we successfully isolated chlorophyll derivative (CD) from the ethyl acetate fraction (EA) of GEE by high-performance liquid chromatography and evaluated their inhibitory effect on intracellular lipid accumulation in 3T3-L1 adipocytes. CD significantly suppressed intracellular lipid accumulation. In addition, CD suppressed adipogenic protein expression such as sterol regulatory element-binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer-binding protein-α (C/EBP-α), and fatty acid binding protein 4 (FABP4). Taken together, our results indicate that CD from GEE inhibits lipid accumulation by suppressing adipogenesis via the downregulation of adipogenic protein expressions in the differentiated adipocytes. Therefore, chlorophyll from G. elliptica has a beneficial effect on lipid metabolism and it could be utilized as a potential therapeutic agent for preventing obesity.

show abstract

Platycodon grandiflorumExtract Reduces High-Fat Diet-Induced Obesity Through Regulation of Adipogenesis and Lipogenesis Pathways in Mice

Hwang

et al. 2019

Journal of Medicinal Food

View full text Add to dashboard Cite

Anti-obesity Effect of Hypsizigus marmoreus in High Fat-fed Mice

Cited by 10 publications

References 27 publications

Lactobacillus fermentum SMFM2017-NK4 Isolated from Kimchi Can Prevent Obesity by Inhibiting Fat Accumulation

Lactobacillus fermentum SMFM2017-NK4 Isolated from Kimchi Can Prevent Obesity by Inhibiting Fat Accumulation

Effects of Ethanol Extracts from Grateloupia elliptica, a Red Seaweed, and Its Chlorophyll Derivative on 3T3-L1 Adipocytes: Suppression of Lipid Accumulation through Downregulation of Adipogenic Protein Expression

Platycodon grandiflorumExtract Reduces High-Fat Diet-Induced Obesity Through Regulation of Adipogenesis and Lipogenesis Pathways in Mice

Contact Info

Product

Resources

About