Anti-obesity effect of Stellaria media methanolic extract in the murine model of cafeteria diet induced obesity

Abstract

Caralluma lasiantha is a succulent plant belongs to Ascalpedaceae family. The objective of this study was to evaluate and to compare the anti-hyperglycemic effect of Caralluma lasiantha with Chromium Picolinate on hyperglycemia induced by Cafeteria-Diet in Wistar albino rats. Hyperglycemia was induced in experimental rats by feeding Cafeteria-Diet for a study period of 90 days. Caralluma lasiantha (10, 20, and 40 mg/kg b.w.) & Chromium Picolinate (10 mg/kg b.w.) were administered orally once every day throughout the study and serum glucose levels were determined in different experimental days. Treatment with Caralluma lasiantha significantly reduced the serum glucose level in dose dependant manner. Data reveal an appreciated beneficial effect of Caralluma lasiantha on hyperglycemic rats. Caralluma lasiantha possesses anti-hyperglycemic effect, which promisingly support the use of Caralluma lasiantha as a food supplement or an adjunct treatment for hyperglycemia INTRODUCTION: Diabetes is increasing at an alarming rate worldwide, which can mainly be attributed to the sedentary life style and calorie-rich diet. Diabetes is often linked with abnormal lipid metabolism and is considered as a major factor for the development of atherosclerosis and cardiovascular complication. 1 Diabetes is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbance of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both. 2 Hyperglycemia is a common end point for all types of DM and it is an important parameter which can be assessed to evaluate the effectiveness of anti-diabetic drugs.

Effect of Stellaria media Tea on Lipid Profile in Rats

“…In the literature, the antiobesity effect of Stellaria media was examined using various rodent obesity models [21][22][23].…”

“…In two other publications, ethanolic and methanolic extracts of Stellaria media were tested in progesterone-induced obesity [22] or in cafeteria diet-induced obesity models in female rats or mice [21]. Administration of 400 mg/kg body weight methanolic extract decreased triacylglycerol levels in both obesity models, but it did not affect total cholesterol levels.…”

Stellaria media (L.) Vill.- A plant with immense therapeutic potentials: phytochemistry and pharmacology

“…In Asia and tropical Africa, leaves decoction is used to treat acute gastrointestinal and respiratory diseases. Also, dried leaves are processed into pills, powders, or decoctions majorly to treat dermal infections, leg swelling, heart infections, thyrotoxicosis and haemorrhoids [16,26]. In India, leaf decoction is used to dressed deep wounds, stop bleeding and lessen tumour [27], pulverized leaves, stem and root is used in form of plaster for dislocated bones and swelling [28].…”

“…The phytochemical appraisal of methanolic leaf extract revealed the presence of flavonoids and β-sitosterol. The alcoholic leaf extract significantly inhibit growth of calorie in the test organisms with lethal dosage at 50% (LD 50 ) of body weight less than 5000 mg/kg [16]. The pancreatic lipase potential of lyophilized juice (LJ) was investigated on plasma triacylglycerol in Swiss albino mice at dosage rate (400-900 mg/kg) for 42 days.…”

“…Some of these compounds are saponins, alkaloids, cardiac glycosides, fatty acids, tannins and terpenoids [12,13,14]. The crude extracts and isolated compounds of S. media demonstrated significant pharmacological activities such as anti-hepatoma [15], anti-obesity [16,17], anticancer [18], antipyretic, anti-inflammatory [19], anti-oxidant [20], antimicrobial [21,22] and anxiolytic potentials [23]. The plant has played remarkable drug discovery roles in conventional and modern medicine.…”