Anti-osteoporosis activity of &lt;i&gt;Astragalus membranaceus&lt;/i&gt; Bunge extract in experimental rats

Li, Hongbo; Nie, Daqing; Wang, Chengwu; Fang, Jiaming; Li, Da

doi:10.4314/tjpr.v15i9.12

Trop. J. Pharm Res

2016

DOI: 10.4314/tjpr.v15i9.12

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Anti-osteoporosis activity of <i>Astragalus membranaceus</i> Bunge extract in experimental rats

Hongbo Li¹,

Daqing Nie²,

Chengwu Wang³

et al.

Abstract: Purpose: To investigate the anti-osteoporosis effect of Astragalus membranaceus (Fisch.) Bunge. extract (AMBE)

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Cited by 3 publications

References 24 publications

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Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Durazzo

Nazhand

Lucarini

et al. 2021

Rend. Fis. Acc. Lincei

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Medicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and treatment of several diseases, as an alternative to chemical drugs. The current work provided a comprehensive overview and analysis of the Astragalus and health relationship in literature. The analysis of their therapeutic potential is thus instrumental to understand their bioactivity. Among these, the flowering medicinal plant Astragalus membranaceus has raised interest due to several beneficial health effects. This perspective review discussed the botanical, geographical, historical, and the therapeutic properties of A. membranaceus, with a special focus on its health improving effects and medicinal applications both in vitro and in vivo. Graphic abstract

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Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Durazzo

Nazhand

Lucarini

et al. 2021

Rend. Fis. Acc. Lincei

View full text Add to dashboard Cite

show abstract

Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment

Huai

Zhang

Wang

et al. 2021

Chinese Herbal Medicines

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Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis

Cao,

Shou,

Xiao

et al. 2024

CDT

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Background: Astragali Radix (AR) has a long history as a traditional Chinese medicine for anti-osteoporosis (OP) treatment. The aim of the study was to explore the effect and optimal regimens of AR and its main ingredients (IAR) in OP treatment. Methods: Eligible animal studies were searched in seven databases (PubMed, Web of Science, MEDLINE, SciELO Citation Index, Cochrane Library, China National Knowledge Infrastructure and Wanfang). The primary outcomes were bone metabolic indices. The secondary outcome measure was the anti-OP mechanism of IAR. Results: 21 studies were enrolled in the study. The primary findings of the present article illustrated that IAR could significantly increase the bone mineral density (BMD), bone volume over the total volume, trabecular number, trabecular thickness, bone maximum load and serum calcium, while trabecular separation and serum C-terminal telopeptide of type 1 collagen were remarkably decreased (P < 0.05). In subgroup analysis, the BMD in the long treatment group (≥ 10 weeks) showed better effect size than the short treatment group (< 10 weeks) (P < 0.05). Modeling methods and animal sex were factors affecting serum alkaline phosphatase and osteocalcin levels. Conclusion: The findings suggest the possibility of developing IAR as a drug for the treatment of OP. IAR with longer treatment time may achieve better effects regardless of animal strain and age.

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Anti-osteoporosis activity of <i>Astragalus membranaceus</i> Bunge extract in experimental rats

Abstract: Purpose: To investigate the anti-osteoporosis effect of Astragalus membranaceus (Fisch.) Bunge. extract (AMBE)

Cited by 3 publications

References 24 publications

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment

Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis

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