Anti-proliferative effect of Euphorbia stenoclada in human airway smooth muscle cells in culture

Chaabi, Mehdi; Freund-Michel, Véronique; Frossard, Nelly; Randriantsoa, Adolphe; Andriantsitohaina, Ramaroson; Lobstein, Annelise

doi:10.1016/j.jep.2006.07.016

Cited by 29 publications

(23 citation statements)

References 29 publications

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“…This proinflammatory cytokine is largely expressed in asthmatic airways (Chaabi et al, 2007). Indeed, quercetin was demonstrated to attenuate NO production in IL-1␤-stimulated hepatocytes through the inhibition of iNOS expression via inhibition of nuclear factor (NF)-B activation (Martínez-Flórez et al, 2005).…”

Section: Plant Extracts Exhibiting No Inhibitory But No Significant Nmentioning

confidence: 99%

Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages

Kumar-Roiné

Matsui

Reybier

et al. 2009

Journal of Ethnopharmacology

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Section: Plant Extracts Exhibiting No Inhibitory But No Significant Nmentioning

confidence: 99%

Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages

Kumar-Roiné

Matsui

Reybier

et al. 2009

Journal of Ethnopharmacology

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“…While myricetin and myricetin 3-O-rhamnoside (3) were previously found in E. aucherii [9] and some other genera of the family Euphorbiaceae [34,35], to the best of our knowledge, myricetin 3-O-glucoside (1) has not previously been reported to occur in any species of the Euphorbia. The co-occurrence of some of these flavonoid glycosides (2)(3)(4)(5)(6)(7)10) in various Euphorbia species might have some chemotaxonomic significance. Dihydrocinnamic acid derivatives and simple coumarins like esculetin (8) commonly occur in the genus Euphorbia as well as in the family Euphorbiaceae [8,9].…”

Section: Resultsmentioning

confidence: 99%

“…In Iranian traditional medicine, the latex and aerial parts of some Euphorbia species are used as a counterirritant remedy to cure rheumatism, arthritis, muscular pain, warts, constipation, and as an antidote for scorpion venom [4]. Treatment of skin diseases, gonorrhea, migraines, intestinal parasites, asthma, acute bronchitis, psoriasis, and eczema with Euphorbia species has also been reported [5][6][7]. Owing to its traditional medical applications, the genus Euphorbia has been the subject of numerous phytochemical and pharmacological studies revealing the presence of diterpenes, flavonoids, sterols, tannins, and triterpenes as the major bioactive constituents [8].…”

Section: Introductionmentioning

confidence: 99%

Free radical scavengers from the aerial parts of Euphorbia petiolata

et al. 2009

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Reversed-phase preparative high-performance liquid chromatography (HPLC) of the methanol extract of the aerial parts of Euphorbia petiolata Banks & Soland, an endemic Iranian medicinal plant, yielded ten free radical scavengers including eight flavonoid glycosides myricetin 3-O-glucoside (1), kaempferol 3-O-(2-O-galloyl)-glucoside (2), myricetin 3-O-rhamnoside (3), quercetin 3-O-glucoside (4), kaempferol 3-O-glucoside (5), quercetin 3-O-rhamnoside (6), kaempferol 3-O-rhamnoside (7), and quercetin 3-O-rutinoside (10), a coumarin esculetin (8) and a phenylpropanoid 2-hydroxydihydrocinnamic acid (9). The structures of these compounds were elucidated conclusively by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. The free radical scavenging properties of these compounds were assessed by the 2,2-diphenyl-1-picrylhydrazyl assay.

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“…Medicinal plants have always an important place in the therapeutic system. The use of natural products in the treatment of various diseases has played an important role in medical therapy for many years and plants of the genus Euphorbia are known to possess considerable medicinal and economic importance components (Tian et al, 2010 andChaabi et al, 2007). Euphorbiaceae is one of the largest families of higher plants comprising about 283 genera and 7500 species (Core, 1962;Lawrence, 1968;Tackholm, 1974;Kirticar and Basu, 1975;Watt and BreyerBrandwijk, 1962;Boulos, 1980 andBenson, 1957) that are further characterized by the frequent occurrence of milky sap.…”

Section: Introductionmentioning

confidence: 99%

Authentication of Euphorbia peplus L. Family Euphorbiaceae Growing in Egypt Using Finger Printing

2016

AJAS

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RAPD-PCR was performed using six random primers to identify the genetic diversity among six plant samples belong to two genera (Euphorbia and Ricinus). The dendrogram, based on genetic distance, depict the relationship among the investigated plant samples, separate clearly the six samples. The closest relationship was observed between E. geniculata and E. aphylla; and E. pulcherrima and E. peplus, while this relationship was quite separated between these four samples and the other two samples E. cactus and R. communis. Fragments generated by the six primers show a polymorphism ratio of 88.9%. Bands 3500 and 750 bp generated by primer OP-Z13, and also bands 2000, 1500, 1400, 1200, 1000, 720 and 550 bp generated by primer OP-A09 existing only in the plant samples of E. geniculata and E. aphylla, which suggest that these bands can be used as a positive molecular marker to identify these plant samples. Bands 2500, 1720, 1650, 1300, 950 and 250 bp generated by primer OP-A09, and band 1200 bp generated by primer OP-A20 and band 350 bp generated by primer OP-Z19 and band 250 bp generated by primer OP-Z17 were common in all plant samples of family Euphorbiaceae. Moreover, band 430 bp generated by primer OP-Z17 was characterized for Ricinus communis and absent in other plants of genus Euphorbia. Also, band 2700 bp generated by primer OP-A20 and band 210 bp generated by primer OP-Z19 existing only in Euphorbia peplus. This study highlights the usefulness of RAPD assay for determining genetic variation in different plant genera and for estimating genetic distances between different plant samples. Moreover, knowledge of genetic distance among genera and species, and genetic diversity/structure within genera could be useful for conservation of genetic resources. Data presented here are the first report in Egypt of genetic variation inside genera Euphorbia and Ricinus described at the molecular level. We consider this work as a first step in molecular characterization of genera Euphorbia and Ricinus, thus, it is recommended to extend the panel of samples and primers in the future.

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Anti-proliferative effect of Euphorbia stenoclada in human airway smooth muscle cells in culture

Cited by 29 publications

References 29 publications

Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages

Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages

Free radical scavengers from the aerial parts of Euphorbia petiolata

Authentication of Euphorbia peplus L. Family Euphorbiaceae Growing in Egypt Using Finger Printing

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