Antibacterial activity against drug-resistant microbial pathogens of cytochalasan alkaloids from the arthropod-associated fungus Chaetomium globosum TW1-1

Bioactivities and Future Perspectives of Chaetoglobosins

“…e configurations of C-17 and C-21 in compounds 25 and 26 are closely related with phytotoxicity potency [12]. In addition, compounds 1, 6 and 18 had also been reported inhibited the hypocotyl and root of Alfalfa seedings [27].…”

“…Except for inhibition against agricultural germs, it also showed the effective on clinical pathogenic bacteria. Hu and his colleague found that compound 57 showed antibacterial activity against Klebsiella pneumoniae (MIC � 4.0 μg/mL) and ESBL-producing Escherichia coli ATCC 35218 (MIC � 16.0 μg/mL), wherein the inhibitory against Klebsiella pneumoniae was stronger than that of the clinically used antibiotic meropenem (MIC � 8 μg/mL), [27].…”

HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17

“…Taken together, the complete structure of 1 was established and accordingly assigned as 6-O-methyl-chaetoglobosin Q, which was probably obtained as an artifact from acidic solvolisis of the epoxide of chaetoglobosin A (2). Additionally, the structures of these known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) were mainly elucidated by spectral data analysis as well as comparison with those reported in the literature. They were identified as chaetoglobosins A-G (2-8) [16][17][18], aureochaeglobosin B (9) [6], isochaetoglobosin D (10) [18], chaetoglobosin Fex (11) [16], penochalasin G (12) [19], armochaetoglobin G (13) [7], prochaetoglobosin I (14) [8], chaetoglobosins V b (15) [8] and Y (16) [18], respectively ( Figure 1).…”

“…The fungus C. globosum has been proven to be a rich source of cytochalasans. In addition, chaetoglobosins were recently found with cytotoxic [6,20,21], antibacterial [8], and phytotoxic activity [16], as well as immunomodulatory properties [22]. With this in mind, compounds 3−16 were screened for their cytotoxicity against a panel of cancer cell lines, H1975, U937, K562, BGC823, MOLT-4, MCF-7, A549, Hela, HL60, and Huh-7.…”

“…Recently, a variety of cycloaddition heterodimers of cytochalasans with novel complicated architectures have been reported, exemplified by asperflavipine A [5], aureochaeglobosins A−C [6]. Chaetoglobosins, 10-(indol-3-yl)- [13]cytochalasans were recently reported to have cytotoxicity [6,7] and antibacterial activity [8], and have attracted great interest from both chemists and pharmacologists [9][10][11][12].…”