Antibacterial activity of some medicinal plants against human pathogens

Abstract

Objective: To assess the antibacterial goods of unrefined solvent methanol concentrate of Calligonum polygonoids, Asphadalous tenuiflous, Pulicaria crispa, and Fagonia cretica against a few human microorganisms. Method: Unrefined methanol concentrates of, Calligonum polygonoids, Asphadalous tenuiflous, Pulicaria crispa and Fagonia cretica at grouping of 500, 250 and 100µg/ml were considered in contrast to Gram-positive Staphylococcus carnosus and Gram -ve K. pneumoniae, S. typhi, E. coli and P. aurogenosa by utilizing circle dissemination strategy. Ciprofloxacin (5µg/ml) was utilized as a kind of perspective medication. Results: The concentrates of all plants showed expansive range antibacterial exercises in a portion subordinate way. The most noteworthy inhibitory area was seen from methanol concentrate of Fagonia cretica against Klebsiella pneumoniae (19mm), S. carnosus (19mm), E. coli (18.67mm) and S. typhi (14mm); Calligonum polygonoids showed against E. coli (15mm), S. typhi (16milimeter) and P. aurogenosa (16milimeter); Pulicaria crispa displayed against K. pneumoniae (19milimeter), E. coli (17milimeter) S. typhi (18milimeter), S. carnosus (19milileter) and P. aurogenosa (16milimeter) while Asphadalous tenuiflous displayed against K. pneumoniae (15milimeter), and E. coli (15milimeter) S. typhi (14.33milimeter), S. carnosus (13.67milimeter) and P. aurogenosa (13.67milimeter). Conclusion: These restorative plants have strong antibacterial action and might be the new hotspot for novel antibacterial compound disclosure for the treatment of medications safe human microorganisms.

Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan

“…P. crispa ’s extracts in all the solvents were found to be active only against S.aureus which is in contrast to previous findings where the methanol extract of P. crispa was reported to be active against P.Aurogenosa exhibiting 2 ± 0.58 mm to 16.33 ± 0.67 mm zone of inhibition ( Arsalan et al, 2022 ). The methanol extract was examined to be effective in inhibiting growth of S. aureus and found more effective than Augmentin and Caricef whereas displayed same antibacterial potential as Amikacin.…”

“…While Chloramphenicol, Oxy-tetracycline, Amikacin, Fucidin, Sparaxin, Urixin, Tazobactum, Cefotax and Ceftriaxone although show greater zone of inhibition but not much significant difference was noted in relevance to that observed by methanol extract which proves that the extract has same effect as these drugs. This is in accord to earlier report by Arsalan et al, (2022) in which noted activity (7 ± 0.58 mm 50 μg/disc) against P. aeruginosa was equal to that observed in our study at the same concentration. This observation supports our findings that activity against P. aeruginosa is present in C. polygonides.…”

Phytochemicals as Antimicrobials: Prospecting Himalayan Medicinal Plants as Source of Alternate Medicine to Combat Antimicrobial Resistance

“…Plants, being easily available and easy to handle, were the first to be used as treatment options for infectious diseases, which continues even today in many tribal communities as an alternative to modern antibiotics. Plants produce hundreds and thousands of structurally and functionally diverse phytochemicals that exert a multitargeted impact on pathogenic microbes, ensuring their death and no further resistance development [ 13 , 14 , 85 , 86 ]. Given the availability of huge phytochemical reserves in the plant kingdom, exploring them for antimicrobial agents seems promising.…”

“…The floristically rich Himalayan region is a potential source of many drug-yielding plants [215]. Many of the medicinal plants in the Himalayas have shown potent antimicrobial activity against pathogenic microbes [14,216]. [212].…”

“…Plants produce secondary metabolites for defensive purposes, many of which have antimicrobial properties, and are still commonly used in traditional medicine [ 10 ]. Further, plants produce a plethora of structurally and functionally diverse phytochemicals, many of which are effective against pathogenic microbes and hence could be explored for developing novel antimicrobials [ 13 , 14 , 15 ]. Systematic screening of phytochemical reservoirs of medicinal plants, known to possess antimicrobial properties, could lead to the identification of novel antimicrobial phytochemicals with unique mechanisms of action.…”