“…We believe, antioxidant and antimicrobial properties of EGCG and Ag NPs, synergistically accelerating the healing ability as time passes. It has been reported that protein content around the wound area influences the Ag release,53 but its contact-dependent antibacterial activity aids additive effect in wound healing. Figure 6HG-Ag-EGCG’s procoagulation and in vivo wound-healing potential.…”
IntroductionAn ideal wound dressing material needs to be predisposed with desirable attributes like anti-infective effect, skin hydration balance, adequate porosity and elasticity, high mechanical strength, low wound surface adherence, and enhanced tissue regeneration capability. In this work, we have synthesized hydrogel-based wound patches having antibacterial silver nanoparticles and antioxidant epigallocatechin gallate (EGCG) and showed fast wound closure through their synergistic interaction without any inherent toxicity.Methods and resultsWound patches were synthesized from modified guar gum polymer and assessed to determine accelerated wound healing. The modified polymer beget chemical-free in-situ synthesis of monodispersed silver NPs (~12 nm), an antimicrobial agent, besides lending ionic surface charges. EGCG impregnated during ionotropic gelation process amplified the efficacy of wound patches that possess apt tensile strength, porosity, and swellability for absorbing wound exudates. Further, in vitro studies endorsed them as non-cytotoxic and the post agent effect following exposure to the patch showed an unbiased response to E coli K12 and B. subtilis. In vivo study using sub-cutaneous wounds in Wistar rats validated its accelerated healing properties when compared to a commercially available wound dressing material (skin graft; Neuskin-F®) through better wound contraction, promoted collagen deposition and enhanced vascularization of wound region by modulating growth factors and inflammatory cytokines.ConclusionSynthesized wound patches showed all the desired attributes of a clinically effective dressing material and the results were validated in various in vitro and in vivo assays.
“…We believe, antioxidant and antimicrobial properties of EGCG and Ag NPs, synergistically accelerating the healing ability as time passes. It has been reported that protein content around the wound area influences the Ag release,53 but its contact-dependent antibacterial activity aids additive effect in wound healing. Figure 6HG-Ag-EGCG’s procoagulation and in vivo wound-healing potential.…”
IntroductionAn ideal wound dressing material needs to be predisposed with desirable attributes like anti-infective effect, skin hydration balance, adequate porosity and elasticity, high mechanical strength, low wound surface adherence, and enhanced tissue regeneration capability. In this work, we have synthesized hydrogel-based wound patches having antibacterial silver nanoparticles and antioxidant epigallocatechin gallate (EGCG) and showed fast wound closure through their synergistic interaction without any inherent toxicity.Methods and resultsWound patches were synthesized from modified guar gum polymer and assessed to determine accelerated wound healing. The modified polymer beget chemical-free in-situ synthesis of monodispersed silver NPs (~12 nm), an antimicrobial agent, besides lending ionic surface charges. EGCG impregnated during ionotropic gelation process amplified the efficacy of wound patches that possess apt tensile strength, porosity, and swellability for absorbing wound exudates. Further, in vitro studies endorsed them as non-cytotoxic and the post agent effect following exposure to the patch showed an unbiased response to E coli K12 and B. subtilis. In vivo study using sub-cutaneous wounds in Wistar rats validated its accelerated healing properties when compared to a commercially available wound dressing material (skin graft; Neuskin-F®) through better wound contraction, promoted collagen deposition and enhanced vascularization of wound region by modulating growth factors and inflammatory cytokines.ConclusionSynthesized wound patches showed all the desired attributes of a clinically effective dressing material and the results were validated in various in vitro and in vivo assays.
Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.
“…The Yang group at Radboud University Medical Center, Netherlands, has been developing nanomaterials for electrospinning and/or electrospraying to produce scaffolds for drug delivery and/or defected tissue repair . At the meeting, they reported the preparation of drug‐loaded poly (lactic‐ co ‐glycolic acid) (PLGA) microspheres by electrospraying, which showed advantages such as a short exposure time of drugs to organic solvents and a high encapsulation efficiency.…”
Section: Scaffolds Based Upon Electrospun Nanofibers For Biomedical Amentioning
Over the past two decades, electrospun nanofibers have been actively explored for a range of applications, including those related to biomedicine, environmental science, energy harvesting, catalysis, photonics, and electronics. Regarding biomedical applications, one can readily produce nanofiber‐based scaffolds with controlled compositions, structures, alignments, and functions by varying the material, design of collector, number of spinnerets, and electrospinning parameters. This report highlights both preclinical and translational applications of electrospun nanofibers and bioprinted constructs presented at the 2019 International Conference on Electrospinning, together with some perspectives on their future development.
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