Antibacterial Polyphenol from Erodium glaucophyllum

Gohar, Ahmed A.; Lahloub, M. F.; Niwa, Masayuki

doi:10.1515/znc-2003-9-1013

Cited by 36 publications

(26 citation statements)

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“…1) were in agreement with previously published data, which allowed the identifi cation of protocatechuic acid (1), gallic acid (2), p-hydroxybenzoic acid (3), and 5-O-caffeoylshikimic acid (4) (Hur et al, 2003;Gohar et al, 2003;Pouchert, 1992;Veit et al, 1992). Previous phytochemical studies on the aerial parts of this plant have described the isolation of lignans and sesquiterpenoids (Bastos et al, 1996), but, to the best of our knowledge, this is the fi rst report of compounds 1 -4 in Z. naranjillo.…”

Section: Resultssupporting

confidence: 90%

Schistosomicidal Evaluation of Zanthoxylum naranjillo and its Isolated Compounds against Schistosoma mansoni Adult Worms

Braguine

Costa

Magalhães

et al. 2009

Zeitschrift Für Naturforschung C

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Chemical investigation of the EtOAc fraction (EF) obtained from the ethanolic extract of Zanthoxylum naranjillo (Rutaceae) leaves (EE) by preparative HPLC resulted in the isolation of protocatechuic acid (1), gallic acid (2), p-hydroxybenzoic acid (3), and 5-Ocaffeoylshikimic acid (4). This is the fi rst time that the presence of compounds 1 -4 in Z. naranjillo has been reported. Compounds 1 -4, the EE, and EF were tested in vitro against Schistosoma mansoni adult worms. The results showed that the S. mansoni daily egg production decreased by 29.8%, 13.5%, 28.4%, 17.7%, 16.3%, and 6.4%, respectively. Compounds 1 and 3 were also able to separate adult worm pairs into male and female. This activity may be correlated with the reduction in egg production, since 1 and 3 showed better inhibitory properties compared with 2 and 4.

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Section: Resultssupporting

confidence: 90%

Schistosomicidal Evaluation of Zanthoxylum naranjillo and its Isolated Compounds against Schistosoma mansoni Adult Worms

Braguine

Costa

Magalhães

et al. 2009

Zeitschrift Für Naturforschung C

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“…Other known compounds such as maslinic acid, gallic acid, and ellagic acid were also isolated and confirmed by direct comparison of their physiochemical and spectroscopic data with previously reported literature (Aher et al, 2010;Gohar et al, 2003;Tanaka et al, 2003). All the isolates were assayed for their inhibitory activity against AR and PTP-1B, and the results are presented in Table 1.…”

Section: Resultssupporting

confidence: 67%

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Sawant

Singh

Dethe

et al. 2015

Pharmaceutical Biology

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Context: Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as jamun, is an Indian plant, traditionally well known for its medicinal properties including antidiabetic activity. Objective: To isolate the antidiabetic compounds from Syzygium cumini seeds and evaluate their activity using aldose reductase (AR) and protein-tyrosine phosphatase 1B (PTP1B) inhibition assays. Materials and methods:The dried seeds were extracted with methanol and partitioned with ethyl acetate, butanol, and water. The extracts were screened for antidiabetic activity at a concentration of 100 mg/mL using in vitro AR and PTP 1B inhibition assays. Results and discussion: The highly enriched fractions obtained from broad ethyl acetate fraction yielded maslinic acid (1), 5-(hydroxymethyl) furfural (2), gallic acid (3), valoneic acid dilactone (4), rubuphenol (5), and ellagic acid (6). Structures were elucidated by 1 H-NMR and 13 C-NMR. The initial ethyl acetate fraction showed AR inhibitory activity with the IC 50 value of 2.50 mg/mL and PTP1B enzyme inhibition with the IC 50 value of 26.36 mg/mL. Compounds 3, 4, 5, and 6 were found to inhibit AR with IC 50 values of 0.77, 0.075, 0.165, and 0.12 mg/mL while the compounds 4, 5, and 6 inhibited PTP1B with IC 50 values of 9.37, 28.14, and 25.96 mg/mL, respectively. Conclusion:The results of this study demonstrate that the isolated constituents show promising in vitro antidiabetic activity and, therefore, can be candidates for in vivo biological screening using relevant models to ascertain their antidiabetic activity.

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“…Among compounds isolated from Phyllanthus amarus, tannins corilagin, geraniin and gallic acid (Foo, 1993) showed in vitro activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli (Adesina et al, 2000;Gohar et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial screening of some Peruvian medicinal plants used in Callería District

Klouček

Polesny

Svobodová

et al. 2005

Journal of Ethnopharmacology

140

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Antibacterial Polyphenol from Erodium glaucophyllum

Abstract: Geraniin and gallic acid were isolated from the alcohol extract of the aerial parts of Erodium glaucophyllum (Geraniaceae). The identity of the compounds was verified through different physical and spectrometric methods. The antibacterial and antifungal activity of geraniin is presented.

Cited by 36 publications

References 1 publication

Schistosomicidal Evaluation of Zanthoxylum naranjillo and its Isolated Compounds against Schistosoma mansoni Adult Worms

Schistosomicidal Evaluation of Zanthoxylum naranjillo and its Isolated Compounds against Schistosoma mansoni Adult Worms

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Antibacterial screening of some Peruvian medicinal plants used in Callería District

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