Antibiotics, intestinal dysbiosis and risk of celiac disease

Rahmoune, Hakim; Boutrid, Nada; Amrane, Mounira; Bioud, B.

doi:10.1016/j.dld.2016.09.004

Cited by 3 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the significant increase in the use of antibiotics among adults and children in the United States is a public health concern. Accumulating evidence supports the notion that long‐term antibiotic exposure alters the functional capacity of the gut microbiota resulting in an increased risk of chronic gut diseases such as inflammatory bowel disease and celiac disease as well as activation of the biological mechanisms that initiate or promote colorectal carcinogenesis .…”

Section: Introductionmentioning

confidence: 98%

Antibiotic‐mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

et al. 2018

View full text Add to dashboard Cite

Recent epidemiological evidence suggests that exposure to antibiotics in early‐to‐middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long‐term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the Apc Min/+ mouse, an established genetic model for familial adenomatous polyposis. Clinical pathologies related to tumor development as well as intestinal and colon tissue histopathology were studied at ages 8, 12, and 16 weeks of age, which correspond to the approximate ages of development of neoplasia, gut inflammation with polyposis, and cancer progression, respectively, in this animal model. We show that the antibiotics significantly increase the severity of clinical symptoms, including effects on intestinal histology and goblet cell numbers. In addition, they promote small intestinal polyposis. Finally, metagenomic analysis of fecal samples demonstrated that antibiotic exposure is associated with a significant but nonuniform depletion of the animal's natural gut flora. Overall, these findings support the premise that long‐term antibiotic exposure mediates the selected depletion of gut microbial communities and the concomitant thinning of the protective mucus layer, resulting in an increase in tumor development.

show abstract

Section: Introductionmentioning

confidence: 98%

Antibiotic‐mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

et al. 2018

View full text Add to dashboard Cite

show abstract

Reply to “Antibiotics, intestinal dysbiosis and risk of celiac disease” by Hakim Rahmoune et al. [Digestive and Liver Disease]

Simre

Uibo

Tillmann

et al. 2017

Digestive and Liver Disease

View full text Add to dashboard Cite

Gut microbiome-based medical methodologies for early-stage disease prevention

Wang

Xü

et al. 2017

Microbial Pathogenesis

View full text Add to dashboard Cite

Antibiotics, intestinal dysbiosis and risk of celiac disease

Cited by 3 publications

References 4 publications

Antibiotic‐mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Antibiotic‐mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Reply to “Antibiotics, intestinal dysbiosis and risk of celiac disease” by Hakim Rahmoune et al. [Digestive and Liver Disease]

Gut microbiome-based medical methodologies for early-stage disease prevention

Contact Info

Product

Resources

About

Antibiotics, intestinal dysbiosis and risk of celiac disease

Cited by 3 publications

References 4 publications

Antibiotic‐mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Antibiotic‐mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Reply to “Antibiotics, intestinal dysbiosis and risk of celiac disease” by Hakim Rahmoune et al. [Digestive and Liver Disease]

Gut microbiome-based medical methodologies for early-stage disease prevention

Contact Info

Product

Resources

About

Antibiotic‐mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Antibiotic‐mediated bacteriome depletion in Apc^Min/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression