Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line

Czerwonka, Arkadiusz; Kaławaj, Katarzyna; Sławińska-Brych, Adrianna; Lemieszek, Marta Kinga; Bartnik, Magdalena; Wojtanowski, Krzysztof Kamil; Zdzisińska, Barbara; Rzeski, Wojciech

doi:10.1016/j.biopha.2018.06.116

Cited by 82 publications

(56 citation statements)

References 48 publications

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“…These results indicate Spirulina extract can directly induce apoptosis to the cancer cells which is in consistence with previous studies. (Czerwonka et al, ; Śmieszek et al, )…”

Section: Resultsmentioning

confidence: 99%

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Kefayat

Ghahremani

Safavi

et al. 2019

Phytotherapy Research

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Spirulina platensis extracts have exhibited considerable anti-cancer effects. To investigate the efficacy of the Spirulina extract enriched for Braun-type lipoprotein (Immulina®) for breast cancer treatment, 4T1 breast tumor-bearing mice were treated with 40 mg/kg Immulina® daily and the tumors' growth and metastasis were assessed. Also, CD4, CD8, and CD56 staining were performed to investigate the Immulina® effect on the immune cells' recruitment to the tumors by immunohistochemistry. Immulina® could significantly (P < 0.001) inhibit 4T1 breast tumors' growth. Immulina®-treated group exhibited a 63% decrease in the tumors' volume in comparison with control (P < 0.001). Also, Immulina® could significantly (P < 0.001) decrease metastatic burden at the vital organs as 68% and 61% decrease in the liver and lungs metastatic colonies were observed, respectively. Also, Immulina® could increase mean survival time of the tumor-bearing mice for 29 days.The Spirulina-treated mice tumors contained significantly more infiltrated NK, CD4+, and CD8+ T lymphocytes in comparison with control. Taking together, Immulina® can be a safe anti-cancer supplement with the ability to cause direct apoptosis to the cancer cells and activate the immune system against tumor. This supplement with natural origin seems to have bright future to help breast cancer patients.

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“…These results indicate Spirulina extract can directly induce apoptosis to the cancer cells which is in consistence with previous studies. (Czerwonka et al, ; Śmieszek et al, )…”

Section: Resultsmentioning

confidence: 99%

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Kefayat

Ghahremani

Safavi

et al. 2019

Phytotherapy Research

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“…Czerwonka et al (14) tested the aqueous extract of Spirulina, which is a dietary supplement derived from algae Arthrospira platensis, against non-small cell lung carcinoma A549…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles in the Use of Natural Products for the Treatment of Lung Cancer

et al. 2019

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Objetivo: Realizar un estudio bibliográfico sobre el uso de nanopartículas en el transporte de productos naturales para el tratamiento del cáncer de pulmón. Métodos: Se realizó una revisión bibliográfica utilizando los descriptores “Nanoparticles”, “Biological Products” y “Lung Neoplasms”, a través de las bases de datos ScienceDirect, PubMed y SciELO, en el período comprendido entre 2009 y 2018. Resultados: Después del análisis de los artículos de acuerdo con los criterios de inclusión, obtuvimos 31 artículos, de los cuales 25.81% hacían referencia a productos naturales en el tratamiento del cáncer de pulmón, el 29.03% a nanopartículas en el tratamiento del cáncer de pulmón y un 45.16 % a nanopartículas como agentes transportadores de productos naturales para el tratamiento del cáncer de pulmón. Conclusión: El uso de nanopartículas permite el transporte de productos naturales, aumentando sus propiedades terapéuticas contra las células de cáncer de pulmón, además de disminuir los efectos secundarios de estos agentes altamente tóxicos.

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“…Several studies indicated that Spirulina or its extract could prevent or inhibit cancer growth (Hirahashi et al, 2002;Subashini et al, 2004). Spirulina is also known to have antibacterial activity and inhibits the replication of the Herpes simplex virus and HIV (Ayehunie et al, 1998;Ozdemir et al, 2004;El-Sheekh et al, 2014). Spirulina platensis have antioxidant, anti-inflamatory and immunomodulator activity (Bashandy et al, 2016;Wu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effect of Spirulina platensis extract and Ulva compressa Linn. on cancer cell lines

Maryati¹,

Saifudin²,

Wahyuni³

et al. 2020

Food Res.

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Studies have shown that algae and seaweed have cytotoxic activity. This study was aimed to determine the cytotoxic activity of Spirulina platensis and Ulva compressa Linn. extracts against cancer cell lines. The cytotoxic activity of the extract was carried out using the MTT ((3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. Results showed that the ethanol extract and methanol extract of Spirulina platensis have no cytotoxic effect against HeLa, WiDr, MCF7 and T47D cells. Water extract of Spirulina platensis had no cytotoxic activity on T47D and Vero cells. Water extracts of Spirulina platensis increase MCF7 cell growth. Phycocyanin powder also stimulates MCF7 cell growth. Ethanol extract of Ulva compressa Linn. exhibited potentially cytotoxic activity against MCF7 and moderate cytotoxic against WiDR cells with IC50 values are 31.86 μg/ mL and 104.93 μg/mL, respectively. It can be concluded that extract of Spirulina platensis has no potential to be developed for cancer therapy. Ulva compressa Linn has the potential to be developed as an anti-cancer. Further research for study the mechanism of anticancer of Ulva compressa Linn on MCF7 was needed.

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Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line

Cited by 82 publications

References 48 publications

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis

Nanoparticles in the Use of Natural Products for the Treatment of Lung Cancer

Cytotoxic effect of Spirulina platensis extract and Ulva compressa Linn. on cancer cell lines

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