Anticancer Effects of HESA-A in Patients With Metastatic Colon Cancer

Ahmadi, Azadeh; Mohagheghi, Mohammad Ali; Karimi, Mehrdad; Golestanha, Seyed Ali; Naseri, Mohsen

doi:10.1177/1534735408327995

Cited by 19 publications

(9 citation statements)

References 15 publications

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“…In addition, the survival of patients until the end of the study, despite a predication of mean survival rate of 1 month, was noteworthy. 23 Ahmadi carried out a study in 2010 on patients with metastatic cancers, who had received HESA-A, and reported that this medicine can improve the quality of life and survival rate in such patients. 24 It is obvious that more animal studies are necessary with different doses in order to determine the optimal dose to prevent oral cancers, paving the way for human studies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of Two Systemic Doses of HESA-A on Prevention of Induced Tongue Neoplasm in Rats

Mehdipour¹,

Zenouz

Abbasi

et al. 2013

Journal of Dental Research

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of Two Systemic Doses of HESA-A on Prevention of Induced Tongue Neoplasm in Rats

Mehdipour¹,

Zenouz

Abbasi

et al. 2013

Journal of Dental Research

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“…In fact, HESA-A is able to completely inhibit the growth of cells at the highest concentration of 5.4 mg/mL, whereas, at minor concentrations its effect is somewhat lower. Nevertheless, this mixture does not affect non tumoral cells and acts by following an apoptotic mechanism [178].…”

Section: Anticancer Activities Of Apium Plantsmentioning

confidence: 99%

Apium Plants: Beyond Simple Food and Phytopharmacological Applications

et al. 2019

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Apium plants belong to the Apiaceae family and are included among plants that have been in use in traditional medicine for thousands of years worldwide, including in the Mediterranean, as well as the tropical and subtropical regions of Asia and Africa. Some highlighted medical benefits include prevention of coronary and vascular diseases. Their phytochemical constituents consist of bergapten, flavonoids, glycosides, furanocoumarins, furocoumarin, limonene, psoralen, xanthotoxin, and selinene. Some of their pharmacological properties include anticancer, antioxidant, antimicrobial, antifungal, nematocidal, anti-rheumatism, antiasthma, anti-bronchitis, hepatoprotective, appetizer, anticonvulsant, antispasmodic, breast milk inducer, anti-jaundice, antihypertensive, anti-dysmenorrhea, prevention of cardiovascular diseases, and spermatogenesis induction. The present review summarizes data on ecology, botany, cultivation, habitat, medicinal use, phytochemical composition, preclinical and clinical pharmacological efficacy of Apium plants and provides future direction on how to take full advantage of Apium plants for the optimal benefit to mankind.

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“…HESA-A is a natural compound of herbal-marine origin which contains inorganic, organic and aqueous fractions with a wide range of therapeutic applications [4,17,18]. In this study, the interaction between HESA-A and influenza virus A/H1N1 was evaluated.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of influenza virus infectivity with herbal-marine compound (HESA-A): an in vitro study in MDCK cells

Mehrbod

Ideris

Omar

et al. 2012

Virol J

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BackgroundThe influenza virus is still one of the most important respiratory risks affecting humans which require effective treatments. In this case, traditional medications are of interest. HESA-A is an active natural biological compound from herbal-marine origin. Previous studies have reported that the therapeutic properties of HESA-A are able to treat psoriasis vulgaris and cancers. However, no antiviral properties have been reported.MethodsThis study was designed to investigate the potential antiviral properties of HESA-A and its effects in modulating TNF-α and IL-6 cytokine levels. HESA-A was prepared in normal saline as a stock solution (0.8 mg/ml, pH = 7.4). Percentages of cell survival when exposed to different concentrations of HESA-A at different time intervals was determined by MTT assay. To study the potential antiviral activity of HESA-A, Madin-Darby Canine Kidney (MDCK) cells were treated with the effective concentration (EC50) of HESA-A (0.025 mg/ml) and 100 TCID50/0.1 ml of virus sample under different types of exposure.ResultsBased on the MTT method and hemagglutination assay (HA), HESA-A is capable of improving cell viability to 31% and decreasing HA titre to almost 99% in co-penetration exposures. In addition, based on quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), it was found that HESA-A causes decrements in TNF-α and IL-6 cytokine expressions, which was significant for TNF-α (p ≤ 0.05) but not for IL-6.ConclusionIn conclusion, HESA-A was effective against influenza infection through suppressing cytokine expression.

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Anticancer Effects of HESA-A in Patients With Metastatic Colon Cancer

Cited by 19 publications

References 15 publications

Evaluation of the Effect of Two Systemic Doses of HESA-A on Prevention of Induced Tongue Neoplasm in Rats

Evaluation of the Effect of Two Systemic Doses of HESA-A on Prevention of Induced Tongue Neoplasm in Rats

Apium Plants: Beyond Simple Food and Phytopharmacological Applications

Attenuation of influenza virus infectivity with herbal-marine compound (HESA-A): an in vitro study in MDCK cells

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