Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake

Rego, Jean–Claude do; Benkiki, Naïma; Chosson, Elizabeth; Kabouche, Zahia; Seguin, Elisabeth; Costentin, Jean

doi:10.1016/j.ejphar.2007.05.008

Cited by 30 publications

(15 citation statements)

References 47 publications

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“…Moreover, other species of the genus Hypericum have also been found to exert antidepressant, antioxidant, antimicrobial, wound healing, hepatoprotective, analgesic and anti-inflammatory activities (Öztürk et al, 1996;Apaydin et al, 1999;Daudt et al, 2000;Gnerre et al, 2001;Mukherjee et al, 2001;Prado et al, 2002;Rabanal et al, 2002Rabanal et al, , 2005Sánchez-Mateo et al, 2002, 2005Viana et al, 2005;Do Rego et al, 2007;Radulović et al, 2007;Savikin et al, 2007;Bonkanka et al, 2008;Crockett et al, 2008;Wang et al, 2008).…”

Section: Introductionmentioning

confidence: 98%

Hypericum grandifolium Choisy: A species native to Macaronesian Region with antidepressant effect

Sánchez-Mateo

Bonkanka

Rabanal

2009

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 98%

Hypericum grandifolium Choisy: A species native to Macaronesian Region with antidepressant effect

Sánchez-Mateo

Bonkanka

Rabanal

2009

Journal of Ethnopharmacology

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“…12 In the last few years, several natural substances have been introduced with potential to fight various human pathologies, particularly neuropsychiatric disorders. This is reflected in the large number of alternative substances assessed in preclinical models of anxiety and depression, including medicinal plants, such as St John's wort, 13,14 , Ginkgo biloba, 15,16 Aloysia polystachya, 17 and Salvia elegans. 18 Antidepressant-like effects of an extract of the leaves of Apocynum venetum L. (Apocynaceae), containing quercetin glycosides such as hyperoside, isoquercitrin, miquelianin and quercitrin, have been shown in rodents using the positive results of forced swimming test.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects of a cocoa polyphenolic extract in Wistar–Unilever rats

Messaoudi¹,

Bisson²,

Nejdi³

et al. 2008

Nutritional Neuroscience

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Depression is a major public health problem affecting about 12% of the world population. Drugs exist but they have many side effects. In the last few years, natural substances (e.g. flavonoids) have been tested to cure such disorders. Cocoa polyphenolic extract is a complex compound prepared from non-roasted cocoa beans containing high levels of flavonoids. The antidepressant-like effect of cocoa polyphenolic extract was evaluated using the forced swimming test in rats. Cocoa polyphenolic extract significantly reduced the duration of immobility at both doses of 24 mg/kg/14 days and 48 mg/kg/14 days, although no change of motor dysfunction was observed with the two doses tested in the open field. The results of the forced swimming test after a subchronic treatment and after an additional locomotor activity test confirm the assumption that the antidepressant-like effect of cocoa polyphenolic extract in the forced swimming test model is specific. Further, it can be speculated that this effect might be related to its content of active polyphenols.

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“…During the previous decade a number of studies focused on the antidepressant-like effects of extracts from several subspecies of St John's wort (Hypericum perfoliatum), which was traditionally used to treat wounds, eczema and disorders of the central nervous system (120) . Not only did these studies reveal replicable antidepressant effects in mice (121 -124) , analysis of monoamine uptake by rat synaptosomes showed that uptake of all three monoamines was inhibited by these extracts (121,124) . In addition to St John's wort, the presence of monoamine reuptake inhibitors was shown in the extracts of Siphocampylus verticillatus (a Brazilian medicinal plant) (125) , in Fructus Akebiae (a traditional Chinese cure for depressive disorders) (126) and Sideritis scardica (used as a tea, flavouring agent and universal remedy around the Mediterranean) (127) .…”

Section: Triple Monoamine Inhibitorsmentioning

confidence: 99%

Food-derived serotonergic modulators: effects on mood and cognition

Hulsken

Märtin

Mohajeri³

et al. 2013

Nutr. Res. Rev.

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The most frequently described drugs in the treatment of mood disorders are selective serotonin reuptake and monoamine oxidase (MAO) inhibitors, enhancing serotonin levels in the brain. However, side-effects have been reported for these drugs. Because serotonin levels in the brain are dependent on the availability of the food-derived precursor tryptophan, foods such as chicken, soyabeans, cereals, tuna, nuts and bananas may serve as an alternative to improve mood and cognition. Here we discuss the effects of high-or low-tryptophancontaining food, as well as plant extracts with a modest monoamine reuptake and MAO-A inhibition functional profile, on mood and cognition in healthy and vulnerable human subjects and rodents. Together the studies suggest that there is an inverted U-shaped curve for plasma tryptophan levels, with low and too high tryptophan levels impairing cognition, and moderate to high tryptophan levels improving cognition. This relationship is found for both healthy and vulnerable subjects. Whereas this relationship may also exist for mood, the inverted U-shaped curve for plasma tryptophan levels and mood may be based on different tryptophan concentrations in healthy v. vulnerable individuals. Animal studies are emerging and allow further understanding of effects and the mode of action of food-derived serotonergic components on mood, cognition and mechanisms. Ultimately, insight into the concentrations of tryptophan and other serotonergic components in food having beneficial effects on mood and cognition in healthy, but particularly vulnerable, subjects may support well-being in our highly demanding society.

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Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake

Cited by 30 publications

References 47 publications

Hypericum grandifolium Choisy: A species native to Macaronesian Region with antidepressant effect

Hypericum grandifolium Choisy: A species native to Macaronesian Region with antidepressant effect

Antidepressant-like effects of a cocoa polyphenolic extract in Wistar–Unilever rats

Food-derived serotonergic modulators: effects on mood and cognition

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