Antidiabetic and antihyperlipidemic effects of a methanolic extract of <i>Mimosa pudica</i> (Fabaceae) in diabetic rats

Parasuraman, Subramani; Ching, Teoh Huey; Leong, Chong Hao; Banik, Urmila

doi:10.1080/2314808x.2019.1681660

Cited by 25 publications

(18 citation statements)

References 32 publications

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“…Flavonoids act as intermediary biosynthetic compound contributed to the inhibition of alpha-amylase, which can restore damaged beta cells in the pancreas. Polyphenolic compounds produced in the plants inhibited glucose transport processes by inhibiting intestinal sodiumglucose co-transporter-1 (S-GLUT-1) (Parasuraman et al, 2019). Referring to the present experimental study, the anti-diabetic effect of the MECG against STZ induced rats might be due to the existence of the polyphenolic compounds, lavonoids, alkaloids, terpenoids, tannins and saponins.…”

Section: Resultsmentioning

confidence: 55%

Antidiabetic and Antihyperlipidemic Activities of Methanolic Extract of Leaves of Coccinia grandis in Diabetic Rats

Ramachawolran¹,

Parasuraman²,

Subramaniam³

et al. 2020

ijrps

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Coccinia grandis is a one of the edible plant and its antidiabetic and antihyperlipidemic activities are not well explored. Hence, the present is planned to study the antidiabetic and antihyperlipidemic activities of methanolic extract of Coccinia grandis leaves in streptozotocin-induced diabetic rats. Coccinia grandis leaves was dried under the shade and extracted with methanol. Preliminary phytochemical and pharmacological analysis were conducted using methanolic extract of Coccinia grandis (MECG) leaves. Female Sprague dawley (SD) was used for acute toxicity studies. Female SD was induced with diabetes by administering streptozotocin (55 mg/kg, i.p.). Glibenclamide (20 mg/kg, p.o.) or MECG leaves (125, 250 and 500 mg/kg, p.o.) used to treat diabetic rats for 28 days. Blood samples were collected at regular intervals to check the antidiabetic effect of MECG. On 28th day, blood sample was collected from the rats to analyse biochemical and lipid profile. MECG did not show any toxic symptoms up to the dose 2000 mg/kg/ BW. MECG at 125, 250 and 500 mg/kg marked significant antidiabetic and antihyperlipidemic activities. Coccinia grandis reduced streptozotocin-induced weight loss and significantly recovered lipid levels. At the end of the study, MECG exhibited significant antidiabetic and antihyperlipidemic activities in streptozotocin-induced diabetes in rats.

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Section: Resultsmentioning

confidence: 55%

Antidiabetic and Antihyperlipidemic Activities of Methanolic Extract of Leaves of Coccinia grandis in Diabetic Rats

Ramachawolran¹,

Parasuraman²,

Subramaniam³

et al. 2020

ijrps

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“…Mimosa pudica L. is reported to have acted as antidiabetic and antihyperlipidemia 83 , as well as anti-hepatitis B 84 The results of previous studies showed that the leaves of Orthosiphon aristatus (Blume) Miq. has antimicrobial activity 88 , anti-cancer 89 , antioxidants 6,89 , and hepatoprotective 90 .…”

Section: Resultsmentioning

confidence: 99%

Ethno-Medicinal Plants Used for Medication of Jaundice by The Chinese, Dayak, and Malays Ethnic in West Kalimantan, Indonesia

Panjaitan¹,

Wang²,

Yuliana³

2021

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As in Indonesia 12 , many other countries in the world also use plants in medicine, including Malaysia 15-17 , the Philippines 18,19 , Thailand, China 20 , Korea 21 , Iran 4 , and India. 2,5,22 Overall, it is stated that medicinal plants generally have lower side effects when compared to synthetic drugs. 7,23,24 West Kalimantan is one of the provinces in Indonesia, which is located on Kalimantan Island. The area of West Kalimantan, which is mostly low lying land, is around 146,807 km2. West Kalimantan consists of 12 districts namely Kubu Raya,

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“…A study revealed that M. pudica seeds had an antidiabetic impact via increasing pancreatic insulin and α-amylase production, as well as flavonoids and phenols, where it significantly decreased lipid peroxidation and enhanced endogenous antioxidant levels [ 55 ]. Another study discovered that methanolic extract of M. pudica demonstrated substantial antidiabetic and antihyperlipidemic effects on streptozotocin-induced diabetes mellitus in rats [ 56 ]. The antidiabetic potential of the methanolic M. pudica extract is equivalent to that of glibenclamide, as indicated by the normalization of blood glucose level tests.…”

Section: Resultsmentioning

confidence: 99%

Response Surface Optimization of Extraction Conditions and In Vitro Antioxidant and Antidiabetic Evaluation of an Under-Valued Medicinal Weed, Mimosa pudica

Baharuddin

Roslan

Bawzer

et al. 2021

Plants

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Mimosa pudica Linn is a well-known perennial herb and is traditionally used in ayurvedic medicine for the treatment of various illnesses. Despite its abundance in nature, the therapeutic potential of this invasive weed is deemed to be underappreciated in Malaysia. Previous studies have found an abundance of bioactive compounds associated with potent antioxidant properties in all parts of the plant. However, the optimum parameters required for the extraction of antioxidant compounds are still unknown. Therefore, the present study aimed to optimize the solvent extraction parameters of M. pudica using response surface methodology to enrich the accumulation of antioxidant compounds in the extracts. The effects of the optimized M. pudica extracts were then evaluated on the cell viability and glucose uptake ability in a 3T3-L1 adipocyte cell line. The highest total phenolic (91.98 mg of gallic acid equivalent per g of the dry extract) and total flavonoid content (606.31 mg of quercetin equivalent per g of the dry extract) were recorded when using 100% ethanol that was five-fold and three-fold higher, respectively, as compared to using 50% ethanol. The extract concentration required to achieve 50% of antioxidant activity (IC50 value) was 42.0 µg/mL using 100% ethanol as compared to 975.03 µg/mL using 50% ethanol. The results indicated that the use of 100% ethanol solvent had the greatest impact on the accumulation of antioxidant compounds in the extract (p < 0.05). Cell viability assay revealed that all extract concentration treatments recorded a viability level of above 50%. Glucose uptake assay using 2-NBDG analog showed that the cells treated with 50 µg/mL extract combined with insulin were five-fold higher than the control group. Given the high antioxidant and antidiabetic properties of this plant, M. pudica can be easily highlighted as a plant subject of interest, which warrants further investigation for nutraceutical prospects.

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Antidiabetic and antihyperlipidemic effects of a methanolic extract of Mimosa pudica (Fabaceae) in diabetic rats

Cited by 25 publications

References 32 publications

Antidiabetic and Antihyperlipidemic Activities of Methanolic Extract of Leaves of Coccinia grandis in Diabetic Rats

Antidiabetic and Antihyperlipidemic Activities of Methanolic Extract of Leaves of Coccinia grandis in Diabetic Rats

Ethno-Medicinal Plants Used for Medication of Jaundice by The Chinese, Dayak, and Malays Ethnic in West Kalimantan, Indonesia

Response Surface Optimization of Extraction Conditions and In Vitro Antioxidant and Antidiabetic Evaluation of an Under-Valued Medicinal Weed, Mimosa pudica

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