Antileishmanial activity of some plants growing in Algeria: &lt;i&gt;Juglans Regia, Lawsonia inermis and Salvia officinalis.&lt;/i&gt;

Serakta, M; Djerrou, Zouhir; Mansour-Djaalab, H.; Kahlouche-Riachi, F.; Hamimed, Selma; Trifa, W; Belkhiri, Abdelmalik; Edikra, N; Pacha, Y. H.

doi:10.4314/ajtcam.v10i3.7

Cited by 17 publications

(15 citation statements)

References 11 publications

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“…A hydroalcoholic extract of a Nigerian S. officinalis showed total inhibition of the L. major growth with reducing the number of their promastigotes (Serakta et al 2013).…”

Section: Antileishmanial Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea (clary sage) have been used as medicinal plants in the folk medicine of several countries. In this review, we discuss the reports that have examined Salvia species with the aim of isolation of pure compounds with different biological activities. The phytochemical analyses of various sage plants have reported 10 monoterpenoids (1-10), 1 sesquiterpenoid (11), 8 labdane (13-20), 15 ent-kaurane (21-35), 82 abietane, rearranged abietane and tanshinone (36-117), 3 icetexane (118-120), 43 clerodane (121-163), and 3 pimarane (164-166) diterpenoids with cytotoxic and antimicrobial, antiprotozoal, antioxidant, phytotoxic and insecticide effects. The other heavier terpenoids, including 3 sesterterpenes (167-169), 10 triterpenoids and b-sitosterol (170-180) have been introduced as minor bioactive compounds in the sage plants. Sahandinone (107), 6,7-dehydroroyleanone, 7-a-acetoxyroyleanone (40), and tanshinone like diterpenoids have been isolated from the roots' extracts of different Salvia species. On the other hand, several radical scavenger phenolic compounds like simple phenolics and caffeic acid derivatives (181-201) including rosmarinic acid, flavonoids (202-217) as well as phenolic diterpenoids, such as carnosol and carnosic acid have been isolated from the aerial parts of these plants. One pyrrole (218) and 3 antimicrobial oxylipins (219-221) are among the other less detected constituents in the members of Salvias. Furthermore, sages also synthesize antifungal, antileishmanial and antimalarial phytochemicals in their roots and shoots, which are reviewed in this paper. We also examine the allelopathic phenomena and the ecologically important phytochemicals identified in different parts of the sage plants. Finally, antifeedant and insecticide phenomena, which are due to the presence of volatile monoterpenes and clerodane diterpenes in these plants, are discussed. Considering the presence of diverse biologically active phytochemicals in the sage plants, they can be suggested as suitable candidates for the formulation of valuable natural medicines.

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“…A hydroalcoholic extract of a Nigerian S. officinalis showed total inhibition of the L. major growth with reducing the number of their promastigotes (Serakta et al 2013).…”

Section: Antileishmanial Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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“…The in vitro antileishmanial activity of the hydroalcoholic extract of Lawsonia inermis was tested on the growth of the promastigotes of Leishmania major. The results showed that Lawsonia inermis extracts reduced the promastigotes number significantly (p<0.01) [91]. The 90% ethanolic extract of Lawsonia inermis leaves was investigated for anticoccidial effects against caecal coccidiosis in broilers.…”

Section: Antiparasitic Effectsmentioning

confidence: 99%

A Review on Lawsonia Inermis: A Potential Medicinal Plant

Al-Snafi

2019

Int J Curr Pharm Sci

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Lawsonia inermis (Family: Lythraceae) contained carbohydrates, phenolic, flavonoids, saponins, proteins, alkaloids, terpenoids, quinones, coumarins, xanthones, fat, resin and tannins. It also contained 2-hydroxy-1,4-naphthoquinone (lawsone). Many alkaloids, naphthoquinone derivatives, phenolics and flavonoids were isolated from different parts of Lawsonia inermis. The pharmacological studies showed that Lawsonia inermis showed antibacterial, antifungal, antiparasitic, molluscicidal, antioxidant, hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and burn healing, immunomodulatory, antiurolithiatic, antidiabetic, hypolipidemic, antiulcer, antidiarrhoeal, diuretic, anticancer and many other pharmacological effects. The current review will highlight the chemical constituents and pharmacological effects of Lawsonia inermis.Lawsonia inermis Linn (Family: Lythraceae) which is commonly known as henna, mainly present in subtropical and tropical areas and is used in all over the world. It was used for over 9000 y for its cosmetic values as a dye. The phytochemical analysis of Lawsonia inermis revealed the presence of carbohydrates, phenolic, flavanoids, saponins, proteins, alkaloids, terpenoids, quinones, coumarins, xanthones, fat, resin and tannins. It also contained 2-hydroxy-1,4naphthoquinone (lawsone). Many alkaloids, napthoquinone derivatives, phenolics and flavonoids were isolated from different parts of Lawsonia inermis. The pharmacological studies showed that Lawsonia inermis showed antibacterial, antifungal, antiparasitic, molluscicidal, antioxidant, hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and burn healing, immunomodulatory, antiurolithiatic, antidiabetic, hypolipidemic, antiulcer, antidiarrhoeal, diuretic, anticancer and many other pharmacological effects. The current review will highlight the chemical constituents and pharmacological effects of Lawsonia inermis. Plant profile SynonymsAlcanna spinosa, Leaves of Lawsonia inermis provide an important cosmetic dye. Henna leaves were extensively used for centuries in the Middle East, the Far East and Northern Africa as dye for nails, hands, hair and textile. Henna was also used in treating skin problems, headache, jaundice, amebiasis and enlargement of the spleen [20,21]. Parts used medicinallyWhole plant, roots, fruits, stem, leaves, barks, inflorescence, rhizome, bulbs, latex, seeds, flowers and oil were used in different ailments [20]. Physiochemical characteristicsPhysiochemical investigation of leaf showed that the total ash was (14.60 %), acid insoluble ash (4.50 %), water soluble ash (3.0 %), loss on drying (4.5 %), alcohol soluble extractive value (3.8 % w/w) and aqueous extractive value (5.0 % w/w) [22]. Chemical constituentsThe preliminary phytochemical analysis of the aqueous extract of Lawsonia inermis revealed the presence of carbohydrates, phenolic compounds, flavonoids, saponins, proteins, alkaloids, terpenoids, 2 quinones, coumarins, xanthones, 6% fat, 2-3% resin and 7-8%...

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“…The lymphocytes were isloated according to the method outlined by Bøyum [15,17]. Extracts were added at concentrations of 100, 50, 25 and 10 µg/mL in DMSO.…”

Section: Cytotoxicity Testmentioning

confidence: 99%

Anti-leishmanial and cytotoxic activities of extracts from three Pakistani plants

Iqbal¹,

Iqbal²,

Umair³

et al. 2016

Trop. J. Pharm Res

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Purpose: To evaluate the in vitro and in vivo anti-leishmanial and cytotoxic activities of extracts of different parts of Lawsonia Inermis, Morus nigra and Ziziphus mauritiana. Methods: The methanol extracts of all three plant materials at concentrations of 10 -100 µg/mL were tested for their in vitro anti-leishmanial effects on L. tropica KWH23 promastigotes for 24 -48 h, relative to negative control and amphotericin-B (standard drug). For in vivo anti-leishmanial activity, the extracts were tested against L. tropica-infected albino mice, while cytotoxicity was investigated against mammalian cells (lymphocytes). Results: For Lawsonia Inermis leaves, mean inhibition of extracellular promastigotes at

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Antileishmanial activity of some plants growing in Algeria: <i>Juglans Regia, Lawsonia inermis and Salvia officinalis.</i>

Cited by 17 publications

References 11 publications

Bioactive phytochemicals from shoots and roots of Salvia species

Bioactive phytochemicals from shoots and roots of Salvia species

A Review on Lawsonia Inermis: A Potential Medicinal Plant

Anti-leishmanial and cytotoxic activities of extracts from three Pakistani plants

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