Antimicrobial Activity of Some EndemicVerbascum,Salvia, andStachysSpecies

Dülger, Başaran; Gönüz, Ahmet

doi:10.1080/13880200490511855

Cited by 31 publications

(6 citation statements)

References 10 publications

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“…Our results revealed a strong activity of ethanolic solvent of Syzygium cumini, Azadirachta indica, Allium sativum, Cordia dichotoma, Trigonella foenum grecum and Ocimum sanctum with MIC varying from 1.56 to 25 mg/mL; 1.56- 25 mg/ml. our MIC results are also in agreement of the other workers [ 48 - 50 ].…”

Section: Discussionsupporting

confidence: 93%

Antimicrobial activity of various ethanolic plant extracts against pathogenic multi drug resistant Candida spp.

Khan¹,

Imran²,

Imran³

et al. 2017

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A total of 50 Candida isolates were isolated and identified from clinical specimens and these were tested for resistance to various antifungal drugs. It was observed multi-drug resistance in all candida isolates by 84%, 62%, 60%, 76%, 46, 30%, and 22% against fluconazole, clotrimazole, Amphotericin B, itraconazole, ketoconazole, miconazole and nystatin tested respectively. The isolates, which were found to be resistant to antifungal drugs were selected and subjected to antifungal testing against six ethanolic plants, extract namely Azadiracta indica, Allium sativum, Cordia dichotoma Ocimum sanctum, Syzygium cumini and Trigonella foenum grecum. All the plant extracts tested were found to effective against all MDR Candida isolates with inhibition zone ranging from 10- 18mm in diameter. Ethanolic extract of Allium sativum was observed most effective against the isolates among all the plants extracts tested. The minimum inhibitory concentration (MIC) of all ethanolic plant extract was recorded ranging from 1.56-25mg/ml against MDR candida isolates. Phytochemical analysis of the alcoholic plant extracts revealed the presence of alkaloid, flavanoid, glycosoid, phenol; phenol, tannins, saponins in all the plants studied. The present study may be successful in identifying the plants with different antimicrobial activity. These plants containing various phytochemicals may be exploited in the treatment of infectious diseases caused by drug-resistant microorganisms.

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Section: Discussionsupporting

confidence: 93%

Antimicrobial activity of various ethanolic plant extracts against pathogenic multi drug resistant Candida spp.

Khan¹,

Imran²,

Imran³

et al. 2017

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“…In general, Gram negative bacteria have been found to be more resistant than Gram positive bacteria 11 – 12 but our results are in contrast to these previous reports. From the present work, it can be stated that methanolic extracts were more potent than aqueous extract.…”

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confidence: 99%

Antimicrobial activity of Terminalia catappa, Manilkara zapota and Piper betel leaf extract

Nair¹,

Chanda²

2008

Indian J Pharm Sci

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Aqueous and methanol extract of the leaves of Terminalia catappa L., Manilkara zapota L. and Piper betel L. were evaluated for antibacterial activity against 10 Gram positive, 12 Gram negative bacteria and one fungal strain, Candida tropicalis. Piperacillin and gentamicin were used as standards for antibacterial assay, while fluconazole was used as standard for antifungal assay. The three plants showed different degree of activity against the microorganisms investigated. The methanolic extract was considerably more effective than aqueous extract in inhibiting the investigated microbial strains. The most active antimicrobial plant was Piper betel.

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“…The studies showing no activity of LSH were conducted for MeOH extracts 26 or EtOH(aq) extracts prepared using a Soxhlet apparatus. 27 The determined activity of 1 indicates that ellagitannins are the compounds responsible for inhibition of E. coli growth by LSH. They are highly polar and heat liable compounds, especially dimeric 2 and 3 , which could explain the lack of activity determined during previous examinations.…”

Section: Results and Discussionmentioning

confidence: 99%

Lythrum salicaria Ellagitannins Stimulate IPEC-J2 Cells Monolayer Formation and Inhibit Enteropathogenic Escherichia coli Growth and Adhesion

et al. 2020

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Lythrum salicaria herb (LSH) was applied in diarrhea therapy since ancient times. Despite empirically referenced therapeutic effects, the bioactivity mechanisms and chemical constituents responsible for pharmacological activity remain not fully resolved. Taking into consideration the historical use of LSH in treatment of diarrhea in humans and farm animals, the aim of the study was to examine in vitro the influence of LSH and its C -glycosylic ellagitannins on processes associated with maintaining intestinal epithelium integrity and enteropathogenic Escherichia coli (EPEC) growth and adhesion. LSH was not only inhibiting EPEC growth in a concentration dependent manner but also its adhesion to IPEC-J2 intestinal epithelial cell monolayers. Inhibitory activity toward EPEC growth was additionally confirmed ex vivo in distal colon samples of postweaning piglets. LSH and its dominating C -glycosylic ellagitannins, castalagin ( 1 ), vescalagin ( 2 ), and salicarinins A ( 3 ) and B ( 4 ) were stimulating IPEC-J2 monolayer formation by enhancing claudin 4 production. Parallelly tested gut microbiota metabolites of LSH ellagitannins, urolithin C ( 5 ), urolithin A ( 6 ), and its glucuronides ( 7 ) were inactive. The activities of LSH and the isolated ellagitannins support its purported antidiarrheal properties and indicate potential mechanisms responsible for its beneficial influence on the intestinal epithelium.

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Antimicrobial Activity of Some EndemicVerbascum,Salvia, andStachysSpecies

Cited by 31 publications

References 10 publications

Antimicrobial activity of various ethanolic plant extracts against pathogenic multi drug resistant Candida spp.

Antimicrobial activity of various ethanolic plant extracts against pathogenic multi drug resistant Candida spp.

Antimicrobial activity of <i> Terminalia catappa</i>, <i> Manilkara zapota</i> and <i> Piper betel</i> leaf extract

Lythrum salicaria Ellagitannins Stimulate IPEC-J2 Cells Monolayer Formation and Inhibit Enteropathogenic Escherichia coli Growth and Adhesion

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