Antimicrobial screening of some newly synthesised transition metal complexes of a dithiocarbazate derived from isoniazid

Interaction of E. coli DNA with diazine-bridged late first row transition metal complexes derived from hexadentate compartmental ligands: an approach to DNA cleavage/binding studies

“…These bands show a shift of ±11-18 nm upon complexation, indicating coordination of the azomethine and hydrazide nitrogen atoms in all the complexes. [Co 2 L 1 (l-Cl)Cl 2 (H 2 O) 2 ]ÁH 2 O shows a well-resolved, medium-intensity band at *500 nm, in good agreement with octahedral Co II [22,23]. Charge transfer bands were present at 423 and 348 nm.…”

“…A band at *750 cm -1 is assigned to the 4 T 1g ? 4 A 2g transition, well within the range for octahedral Co II complexes [22,23]. In [Ni 2 L 2 (l-Cl)Cl 2 (H 2 O) 2 ], the bands around 680, 530 and 495 nm can be attributed, in an octahedral [24,25] model, to the three spin allowed transitions, 3 A 2g ?…”

Antimicrobial and toxicological studies of some metal complexes of 4-methylpiperazine-1-carbodithioate and phenanthroline mixed ligands

“…Antimicrobial studies against the selected strains were performed by determining MIC (mimimum inhibitory concentration)/break point value by agar dilution method (6,14). The results were compared with that of chloramphenicol (MIC = 4 gmL -1 ) (7), a standard broadspectrum antibiotic for bacterial strains and nystatin (4-8 gmL -1 ) (11) for Candida albicans as positive control.…”

Synthesis, characterisation and biological activities of S-2- or S-4-methylbenzyl-β-N-(di-2-pyridyl)methylenedithiocarbazate and Cu(II), Ni(II), Zn(II) and Cd(II) complexes

“…The π-delocalisation of charge and the configurational flexibility of their molecular chain give rise to a great variety of coordination modes [14][15][16][17][18]. Their chemistry and pharmacological applications have been widely investigated as well [1][2][3][4][5][6][15][16][17][18].Coordination compounds, especially those that contain nitrogen-sulphur ligands are synthesized via relatively simple, cost-effective procedures and it has been observed that small changes in their structure, such as change of substituents and their chelation to different metal ions cause great changes in their bioactivities. The coordination of these compounds often lead to enhanced biological activity in several pathogenic fungi [3,[19][20][21].…”