Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet

Guo, Yangming; Wu, Guanzhong; X, Su; Yang, Hongxia; Zhang, Juan

doi:10.1016/j.nutres.2009.09.005

Cited by 71 publications

(55 citation statements)

References 26 publications

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“…Considering few references about the relation between daidzein and beef cattle, this paper only compared our results with those obtained from mice or other animals. Similar to our results, Guo et al 16 and Cao et al 17 reported reduced epididymal and subcutaneous fat-pad weights and visceral fat content in mice in response to daidzein supplementation. Daidzein supplementation also increased carcass bone proportion of beef cattle in the present study.…”

Section: Discussionsupporting

confidence: 92%

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

Zhao

Zhou

Bao

et al. 2014

Exp Biol Med (Maywood)

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An experiment was conducted to determine the effects of soy isoflavone daidzein on carcass characteristics, fat deposition, meat quality, and blood metabolites in finishing steers. Fourteen crossbred steers were used in a 120-d finishing study. These steers were stratified by weight into groups and randomly allotted by group to one of two dietary treatments: (1) control and (2) daidzein (500 mg/kg concentrate). The steers were fed a 90% concentrate diet. Supplemental daidzein did not affect slaughter weight, hot carcass weight, and dressing percentage, but tended to reduce fat proportion (not including intramuscular fat) in carcass and backfat thickness of steers. The carcass bone proportion was greater in steers fed daidzein diets than those fed control diets. Daidzein supplementation reduced pH at 24 h after slaughtered and moisture content and increased isocitrate dehydrogenase activity, fat content (16.28% and 7.94%), marbling score (5.29 and 3.36), redness (a*), and chroma (C*) values in longissimus muscle relative to control treatment. The concentrations of blood metabolites including glucose, blood urea nitrogen, triglyceride, total cholesterol, non-esterified fatty acid, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were all lower in steers fed daidzein diets than those fed control diets. Current results suggest that supplemental daidzein can affect lipid metabolism, increase intramuscular fat content and marbling score, and improve meat quality in finishing steers. Daidzein should be a promising feed additive for production of high-quality beef meat.

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Section: Discussionsupporting

confidence: 92%

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

Zhao

Zhou

Bao

et al. 2014

Exp Biol Med (Maywood)

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“…Oral supplementation of EEB significantly lowered TC, TGs, FFAs and PLs in both plasma and liver and LDL levels in plasma of HCD-fed obese rats. Our finding are in line with Yongqi et al (2009) who reported that supplementation of daidzein derivative from soy germ koji to fed animals led to hypolipidemic state by decreasing cholesterol absorption and secretion from the intestine [42] [43].…”

Section: Discussionsupporting

confidence: 92%

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Padmaja¹,

Naidu²,

Kumar³

et al. 2014

ABB

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Obesity is well recognized as a global public health concern and the quest continues to explore natural product-based novel therapeutics. Bauhinia purpurea finds its place in traditional medicine as an effective anti-ulcer, antiplatelet, wound healing and hypolipidemic agent. The present study investigated the effects of ethanolic extract of Bauhinia purpurea (EEB) on the changes in body weight, lean mass, fat free mass, fat percent, tissue and plasma lipid profiles, plasma glucose, insulin and insulin resistance as well as on the activity of amylase, lipase, leptin and adiponectin levels in high caloric diet (HCD) induced obese rats. After induction of obesity with HCD, rats were administered orally with EEB (100, 200 and 300 mg•kg −1 BW) or orlistat (5 mg•kg −1 BW) once daily for 42 days. HCD substantially increased the body weight, fat free mass, fat percent, glucose, insulin resistance, tissue and plasma lipid profiles (Except HDL), leptin and the activities of amylase and lipase. EEB at a dose of 300 mg•kg −1 BW exerted its therapeutic effects similar to orlistat in decreasing body weight, insulin resistance, levels of glucose, leptin, plasma and tissue lipids, lipase and amylase but increasing HDL and adiponectin in HCD fed obese rats, which could be due to bioactive factors present in EEB, as revealed by LC-MS analysis. These findings suggest that EEB administration suppresses high-caloric-diet-induced obesity and it can be developed as a potential candidate for the treatment of obesity and associated complications.

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“…2). This phenomenon resembled that in the previous reports, in which it was reported that daidzein causes depression in body weight in mice and rats, 29,30) suggesting that daidzin might have the effect of decreasing body weight gain as the glycoside-form daidzein. It is known that a high-fat diet increases adipose tissue, which is a crucial factor in the development of obesity.…”

Section: Discussionsupporting

confidence: 90%

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Zang

Igarashi

2015

Bioscience, Biotechnology, and Biochemistry

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Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet

Cited by 71 publications

References 26 publications

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

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Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet

Cited by 71 publications

References 26 publications

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

Daidzein enhances intramuscular fat deposition and improves meat quality in finishing steers

Antiobesity Activity of &lt;i&gt;Bauhinia purpurea&lt;/i&gt; Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

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Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats