Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double‐blind, placebo‐controlled trial

Abstract

Objective: The effects of actiponin was investigated, a heat-processed Gynostemma pentaphyllum extract, on body weight, fat loss, and metabolic markers of Korean participants in a 12-week, randomized, double-blind, placebo-controlled clinical trial. Design and Methods: Obese participants (BMI 25 kg m 22 and WHR 0.90 for male or WHR 0.85 for female) who had not been diagnosed with any disease and met the inclusion criteria were recruited for this study. The 80 subjects were randomly divided into actiponin (n 5 40, 450 mg day 21 ) and placebo (n 5 40) groups. Outcomes included measurement of efficacy (abdominal fat distribution, anthropometric parameters, and blood lipid profiles) and safety (adverse events, laboratory test results, electrocardiogram data, and vital signs). Results: During 12-week of actiponin supplementation, total abdominal fat area, body weight, body fat mass, percent body fat, and BMI were significantly decreased (P 5 0.044, P < 0.05, P < 0.0001, P < 0.0001, and P < 0.05, respectively) in the actiponin group compared to the placebo group. No clinically significant changes in any safety parameter were observed. Conclusion: Our study revealed that actiponin is a potent antiobesity reagent that does not produce any significant adverse effects. These results suggest that actiponin supplementation may be effective for treating obese individuals.

Salicornia herbaceaprevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high-fat diet

“…From recent studies it is evident that phytotherapy and functional foods are effective against obesity in both human and rodent models, with no significant adverse effects . Thus complementary and alternative medicines (CAM) have become a preferred means of weight loss.…”

Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet

“…Similarly, in human subjects, oral supplementation of quercetin at 50 to 150 mg/day (17) or even 500 mg/day (18) failed to produce a significant difference in the serum lipid profile. However, quercetin-rich plant-based supplements have shown to lower total cholesterol in animals (13) and humans (19). In our study, animals receiving 0.06 mg/day quercetin obtained from the onion peel extract showed effective lipid-ameliorating activity.…”

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

“…In addition, some studies have recognized the effectiveness of herbal plants on body fat percent (BF%), fat mass (FM), and fat‐free mass (FFM). Also, significant decrease was seen in FM and BF% by green tea (green tea with dose of 6,000 mg/day and catechins with doses of 458, 468, and 886 mg/day; Tsai et al, , Wang et al, ), I. gabonensis (with dose of 300 mg/day; Ngondi et al, ), H. sabdariffa (with dose of 75 mg/day; Chang et al, ), Phaseolus Vulgaris (with dose of 445 mg/day; Celleno et al, , Perricone, ), G. cambogia (with doses of 2,400 and 3,000 mg/day [equivalent 1,200 and 1,500 mg hydroxycitric acid]; Heymsfield et al, , Vasques et al, ), Ecklonia cava (with doses of 72 and 144 mg/day; Shin, Kim, Park, Lee, & Hwang, ), cumin (with dose of 3,000 mg/day; Zare et al, ), Coleus forskolii (with dose of 250 mg/day; Loftus, Astell, Mathai, & Su, ), Sorghum tea (with dose of 1,000 ml/day) (Yokomichi, ), Gynostemma pentaphyllum (with dose of 450 mg/day; Park et al, ), and cinnamon (with dose of 550 mg/day; Vafa et al, ).…”