Antioxidant activity and antidiabetic activities of Northern Thai indigenous edible plant extracts and their phytochemical constituents

Dedvisitsakul, Plaipol; Watla‐iad, Kanchana

doi:10.1016/j.heliyon.2022.e10740

Cited by 27 publications

(20 citation statements)

References 88 publications

(111 reference statements)

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“…Normally, it is associated with post-prandial hyperglycemia (abnormal glucose levels) and abnormal release of reactive free oxidizing radicals (reactive oxygen species (ROS)) [5,6]. Cardiomyopathy, polyphagia, kidney failure, coronary heart disease, polydipsia, morbidity, mortality, nephropathy, neuropathy, glycosuria, and retinopathy are the common types of clinical complications that are related to type-2 diabetes mellitus and abnormal levels of blood glucose [7][8][9]. Additionally, lipid peroxidation, insulin resistance, destruction of blood vessels, and damage of organelles were reported as pathophysiological side effects of the abnormal increase in the concentrations of ROS and their associated oxidative stresses [6,8,10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Sulfonylureas, biguanides, a thiazolidinedione, voglibose, miglitol, and acarbose are widely used commercial drugs in the role as antidiabetic agents that cause significant declination in the levels of ROS radicals and hyperglycemia [6,8,12]. Unfortunately, several types of commonly used commercial drugs are expensive products, and their applications can cause notable health sides effects such as diarrhea, severe hypoglycemia, hepatotoxicity, meteorism, and abdomen distention [6,13].…”

Section: Introductionmentioning

confidence: 99%

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Insight into the Potential Antioxidant and Antidiabetic Activities of Scrolled Kaolinite Single Sheet (KNs) and Its Composite with ZnO Nanoparticles: Synergetic Studies

et al. 2023

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The kaolinite sheets were scrolled by sonication-induced chemical delamination processes into well-developed nanotubes (KNs) which were used as substrates for microwave-based ZnO nanoparticles (ZnO/KNs). The biological activities of synthetic ZnO/KNs structures, in terms of the antioxidant and antidiabetic properties, were assessed in comparative studies with the separated phases of the synthetic ZnO and KNs as well as the commercially used ZnO. The KNs substrate resulted in a notable enhancement in the antioxidant and antidiabetic properties of ZnO, which was assigned positive influence on the surface area, interactive interfaces, charge separation, and agglomeration properties of ZnO in addition to the detectable bioactive properties of the KNs structure. The ZnO/KNs structure achieved remarkable scavenging efficiencies for 1, 1-diphenyl-2-picrylhydrazil (DPPH) (89.8 ± 1.57%), nitric oxide (90.6 ± 1.63%), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) (86.8 ± 1.28%), and superoxide (43.9 ± 1.72%) radicals. Additionally, it shows high inhibition effects on porcine α-amylase (84.3 ± 1.92%), crude α-amylase (70.6 ± 1.37%), pancreatic α-Glucosidase (94.7 ± 1.54%), crude α-Glucosidase (95.4 ± 1.64%), and amyloglucosidase (95.3 ± 1.32%) enzymes. This antidiabetic activity is significantly higher than the activity of miglitol and close to or slightly higher than acarbose, which leads us to recommend the use of ZnO/KNs when considering the cost and side effects of the commercially used drugs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insight into the Potential Antioxidant and Antidiabetic Activities of Scrolled Kaolinite Single Sheet (KNs) and Its Composite with ZnO Nanoparticles: Synergetic Studies

et al. 2023

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“…In the previous study, the TPC and TFC of E. scandens were found to be 0.38 ± 0.03 mg GAE/g DW and 0.068 ± 0.01 mg CE/g DW, respectively [19]. In the present study, the TPC and TFC of this plant were reported as 179.43 ± 3.40 mg GAE/g, and the TFC was reported as 10.63 ± 0.34 mg QE/g, respectively.…”

Section: Discussionmentioning

confidence: 82%

“…In the present study, the TPC and TFC of this plant were reported as 179.43 ± 3.40 mg GAE/g, and the TFC was reported as 10.63 ± 0.34 mg QE/g, respectively. Previously, the IC 50 value for the α-amylase and α-glucosidase inhibition of the 95% ethanolic extract of this plant was found to be 2.28 ± 0.01 mg/mL and 2.97 ± 0.03 mg/ mL, respectively [19].…”

Section: Discussionmentioning

confidence: 94%

Antioxidant, α-Glucosidase, and α-Amylase Inhibition Activities of Erythropalum scandens Blume

Adhikari

Shrestha

et al. 2023

Journal of Chemistry

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Diabetes is a major health problem worldwide, which is increasing day by day. Since ancient times, medicinal plants have been a key source of medicinal agents, and many of them have been authorized as strong medications or drug candidates. This study evaluated the antioxidant, α-glucosidase, and α-amylase inhibition activities of Erythropalum scandens Blume. The plant revealed the significant antioxidant and in vitro antidiabetic activity. The crude methanolic extract reported the highest antioxidant activity with an IC50 of 59.35 ± 5.47 μg/mL, followed by its dichloromethane (DCM) and ethyl acetate (EA) fractions with an IC50 of 66.45 ± 2.46 μg/mL and 80.46 ± 2.69 μg/mL, respectively, as compared to the standard quercetin’s IC50 value of 6.29 ± 1.02 μg/mL. Among the crude extract and its fractions, the EA fraction disclosed the significant inhibiting activity against α-glucosidase and α-amylase with an IC50 value of 17.92 ± 0.88 μg/mL and 44.51 ± 0.12 μg/mL, respectively. This research work has scientifically validated the traditional use of this plant.

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“…These secondary metabolites are considered an efficient electron donor, provide as reduction agents, donors of hydrogen and singlet oxygen scavengers. 7 Also, polyphenols and flavonoids compounds are involved in the inhibition of hydrolytic and oxidative enzymes. 8 This oxidative disturbance may guide to other diseases such as inflammation and cancer.…”

Section: Introductionmentioning

confidence: 99%

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2023

JABB

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The aim of this study was to investigate the antioxidant, anti-inflammatory, and anticancer properties of Tunisian Suaeda mollis specie after fractionation by increasing polarity of several extracts (Hexane, Dichloromerthane, Methanol and water). Water and methanol extracts of S. mollis exhibited the best in vitro antioxidant ability (2.92±0.19 and 2.77±0.21 µmol TE/mg, respectively), while, dichloromethane extract displayed the highest ex vivo antioxidant activity with an IC 50 equal to 1.73 µg/ml. Besides, hexane extract showed an important anti-inflammatory effect inhibiting NO with 55.9% at 160 µg/ml. Finally, dichloromethane extract displayed a potent anticancer activity against cancerous cells A-549 with an IC 50 equal to 70±7 µg/ml as well as non cancerous cells Detroit-551 and WS1 (IC 50 =81±1 and 62±5 µg/ml, respectively) using resazurin test. Moreover, hexane extract is efficient against Caco-2 (IC 50 =122 µg/ml). Overall, the results suggested that biological activities are influenced by solvent polarity and extractability.

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Antioxidant activity and antidiabetic activities of Northern Thai indigenous edible plant extracts and their phytochemical constituents

Cited by 27 publications

References 88 publications

Insight into the Potential Antioxidant and Antidiabetic Activities of Scrolled Kaolinite Single Sheet (KNs) and Its Composite with ZnO Nanoparticles: Synergetic Studies

Insight into the Potential Antioxidant and Antidiabetic Activities of Scrolled Kaolinite Single Sheet (KNs) and Its Composite with ZnO Nanoparticles: Synergetic Studies

Antioxidant, α-Glucosidase, and α-Amylase Inhibition Activities of Erythropalum scandens Blume

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