Antioxidant activity and chemical constituents of some Indonesian fruit peels

Muhtadi, Muhtadi; Haryoto,; Sujono, Tanti Azizah; Suhendi, Andi; Khong, Heng Yen

doi:10.5958/j.0975-6892.6.1.006

Cited by 9 publications

(12 citation statements)

References 7 publications

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“…In the study conducted by Muhtadi et al [2], it has been shown that RFPEs had a radical inhibitory activity value (IC 50 ) of 7.74±0.76 µg/ mL. In this study, RFPE has been formulated in a gel nanoemulsion and radical values obtained inhibitory activity (IC 50 ) of 9.32±0.05 µg/mL.…”

Section: Determination Antioxidant Activity By Dpph Methodsmentioning

confidence: 66%

“…Antioxidant activity could not be separated from any chemical active compounds, such as ellagic acid, corilagin, and geraniin [3]. Our previous study on the isolation of active compound found the ethyl gallic as an active compound [2].…”

Section: Introductionmentioning

confidence: 87%

“…Pharmacology showed that rambutan extract has some antidiabetic and anticholesterolemia activities in rat models [1]. Our previous research showed that rambutan fruit peel extracts had good potency as the antioxidant higher than Vitamin E as standard [2]. As a consequence, the rambutan fruit peel could be the natural antioxidant resources.…”

Section: Introductionmentioning

confidence: 98%

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Gel Nanoemulsion of Rambutan (Nephelium Lappaceum L.) Fruit Peel Extracts: Formulation, Physical Properties, Sunscreen Protecting, and Antioxidant Activity

Muhtadi

Suhendi

Wikantyasning

2017

Asian J Pharm Clin Res

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Objective: The aim of this study is to determine the optimum formulation of gel nanoemulsion of the rambutan fruit peel extracts (RFPEs), sunscreen protecting factor, and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric thiocyanate (FTC) methods. Materials and Methods:Formulation was optimized based on the variety of concentrations of RFPE, namely, 0.25%; 0.38%; 0.51%; and 0.63%. Gel nanoemulsion was characterized based on a number of the physical and chemical properties, such as pH, viscosity, adhesion, spread property, stability, and particle size. Sunscreen protecting factor and antioxidant activity were conducted using spectrophotometer ultraviolet-visible. Results:The result showed that the particle size of gel nanoemulsion formulation 1 (FI), FII, FIII, and FIV were at 13.30±4.00 nm, 1.90±9.70 nm, 2.70±13.60 nm, and 14.50±2.50 nm, respectively. Based on transmission electron microscopy image, it showed that formula with the concentration of 0.25% of RFPE could form nanoemulsion particle aggregate with good dispersion. The varied concentrations of RFPE statistically indicated no significant differences among adhesive, spread property, and viscosity of all formulas. Formula 1 showed the highest sunscreen protecting factor with the value of sun-protecting factor at 6.450±0.002, followed by F4, F3, and F2 with the values in sequence at 9.370±0.002, 10.120±0.001, and 13.120±0.001, respectively. The antiradical activity of the gel nanoemulsion RFPE with inhibitory concentration 50% (IC 50 ) value was at 9.32±0.05 µg/ mL. Meanwhile, the higher value of branded product and Vitamin E, which IC 50 were 40.41±0.97 and 10.41±0.05 µg/mL, respectively. In contrast, gel nanoemulsion of RFPE had the lowest inhibition on FTC method. The highest inhibition potency was showed by Vitamin E (79.07±7.62%), followed by branded product (60.07±13.23%) as comparison. Conclusions:The gel nanoemulsion of RFPEs of FIII had a good physical stability and sunscreen protection activity. The antioxidant activity of gel nanoemulsion of RFPE by DPPH and FTC methods were IC 50 value of 9.32±0.05 µg/mL and % inhibition of 51.09±0.99%.

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Section: Determination Antioxidant Activity By Dpph Methodsmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 87%

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Gel Nanoemulsion of Rambutan (Nephelium Lappaceum L.) Fruit Peel Extracts: Formulation, Physical Properties, Sunscreen Protecting, and Antioxidant Activity

Muhtadi

Suhendi

Wikantyasning

2017

Asian J Pharm Clin Res

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“…Rambutan peel ethanol extract contains epigallocatechin-3-gallate [13] which have activity as antihyperglycemia [14] as well as powerful antioxidants [15]. Rambutan fruit peels ethanol extract be known to have a greater ability to capture as an antioxidant free radical DPPH compared with vitamin E [16,9]. Haruenkit et al [10] explained that the content of polyphenols, flavonoids, flavanols, tannins and ascorbic acid acts as an antioxidant.…”

Section: Introductionmentioning

confidence: 98%

“…Based on the research of Batubara [8] ethanol extract the inner and outer skin of durian fruit had antioxidant activity. Durian acts as an antioxidant [9] and antiproliferative [10]. The content of polyphenols and flavonoids can inhibit rise high enough plasma lipids and plasma antioxidant activity in vivo tests on Wistar rats were weighed cholesterol [11].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Durian (Durio Zibethinus Murr.) and Rambutan (Nephelium Lappaceum L.) Fruit Peels in Alloxan Diabetic Rats

Muhtadi

Primarianti

Sujono

2015

Procedia Food Science

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The present study was carried out to evaluate the in alloxan (150 mg/kgb.wt) induced diabetic rats. The ethanolic extract of Durian (Durio zibethinus Murr.) and rambutan (Nephelium lappaceum L.) fruit peels administered orally to the diabetic rats for 11 days, produced significant decrease in the level of blood glucose. The highest percentage reduction in blood glucose levels were shown of rambutan fruit peels extract with dose 500 mg/kgb.w and the value of persentage reduction were 61.76±4.26%.

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Rambutan (Nephelium lappaceum L.): A potential fruit for industrial use, serving nutraceutical and livelihood interests and enhancing climate resilience

Bhattacharjee

Das

et al. 2022

South African Journal of Botany

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Antioxidant activity and chemical constituents of some Indonesian fruit peels

Cited by 9 publications

References 7 publications

Gel Nanoemulsion of Rambutan (Nephelium Lappaceum L.) Fruit Peel Extracts: Formulation, Physical Properties, Sunscreen Protecting, and Antioxidant Activity

Gel Nanoemulsion of Rambutan (Nephelium Lappaceum L.) Fruit Peel Extracts: Formulation, Physical Properties, Sunscreen Protecting, and Antioxidant Activity

Antidiabetic Activity of Durian (Durio Zibethinus Murr.) and Rambutan (Nephelium Lappaceum L.) Fruit Peels in Alloxan Diabetic Rats

Rambutan (Nephelium lappaceum L.): A potential fruit for industrial use, serving nutraceutical and livelihood interests and enhancing climate resilience

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