Antioxidant activity of eugenol in Piper betel leaf extract

Aara, Anjum; Chappidi, Vani; Ramadas, Madhavan Nirmal

doi:10.4103/jfmpc.jfmpc_809_19

Cited by 25 publications

(16 citation statements)

References 20 publications

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“…Still, it was always higher than that of the solution without eugenol added ( Figure 11 ). This result may be because eugenol is an antioxidant with good reducibility [ 37 ]. Moreover, it further demonstrated that the browning degree is not negatively correlated with the reducing capability.…”

Section: Resultsmentioning

confidence: 99%

Changes in Browning Degree and Reducibility of Polyphenols during Autoxidation and Enzymatic Oxidation

Zhou

Iqbal

et al. 2021

Antioxidants

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In the present study, the browning degree and reducing power of browning products of catechin (CT), epicatechin (EC), caffeic acid (CA), and chlorogenic acid (CGA) in autoxidation and enzymatic oxidation were investigated. Influencing factors were considered, such as pH, substrate species and composition, and eugenol. Results show that polyphenols’ autoxidation was intensified in an alkaline environment, but the reducing power was not improved. Products of enzymatic oxidation at a neutral pH have higher reducing power than autoxidation. In enzymatic oxidation, the browning degree of mixed substrates was higher than that of a single polyphenol. The reducing power of flavonoid mixed solution (CT and EC) was higher than those of phenolic acids’ (CA and CGA) in autoxidation and enzymatic oxidation. Eugenol activity studies have shown that eugenol could increase autoxidation browning but inhibit enzymatic browning. Activity test and molecular docking results show that eugenol could inhibit tyrosinase.

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Section: Resultsmentioning

confidence: 99%

Changes in Browning Degree and Reducibility of Polyphenols during Autoxidation and Enzymatic Oxidation

Zhou

Iqbal

et al. 2021

Antioxidants

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“…134 The DPPH radical scavenging assay in human breast cancer MCF‐7 cells using crude ethanolic extract of leaves showed antioxidant activity with (IC 50 ) of 30.0 ± 0.1 µg/ml. 105 used different solvent extracts of leaves (ethanol, ethyl acetate, hexane +petroleum ether and aqueous extract of leaves) and found potential antioxidant properties of all extracts in all assays (DPPH, reducing power activity and hydrogen peroxide scavenging assay) in a concentration‐dependent manner 135 Ethanolic extract from leaves using the in vitro ORAC (oxygen radical absorbance capacity) assay 136 and methanol extract of leaves using in vitro nitric oxide, hydroxyl radical and reducing power assay, ferric ion RPA (Robotic Process Automation) method 137 showed potential antioxidant activity through free radical scavenging.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Biswas

Anand

Saha

et al. 2022

J Cellular Molecular Medi

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Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart‐shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also used for religious purposes. Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P . betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many more. Immense attention has been paid to nanoformulations and their applications. The application of P . betle did not show cytotoxicity in preclinical experiments, suggesting that it could serve as a promising therapeutic candidate for different diseases. The present review comprehensively summarizes the botanical description, geographical distribution, economic value and cultivation, ethnobotanical uses, preclinical pharmacological properties with insights of toxicological, clinical efficacy, and safety of P . betle . The findings suggest that P . betle represents an orally active and safe natural agent that exhibits great therapeutic potential for managing various human medical conditions. However, further research is needed to elucidate its underlying molecular mechanisms of action, clinical aspects, structure–activity relationships, bioavailability and synergistic interactions with other drugs.

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“…The leaves have phytochemicals that are pharmacologically active and are often used for several treatments. This is because the green betel leaves and the red betel leaves contain antioxidant [7], antidiabetic [8], antifungal [9], and antibacterial [10] properties.…”

Section: Introductionmentioning

confidence: 99%

Brine Shrimp (Artemia salina Leach.) Lethality Test of Ethanolic Extract from Green Betel (Piper betle Linn.) and Red Betel (Piper crocatum Ruiz and Pav.) through the Soxhletation Method for Cytotoxicity Test

Nerdy

Lestari

Sinaga

et al. 2021

Open Access Maced J Med Sci

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Traditional medicine is currently being explored and developed widely by various countries because its cost effectiveness and reduced side effects. The green betel (Piper betle Linn.) and the red betel (Piper crocatum Ruiz and Pav.) are plants from the same Piper genus that are widely cultivated in Indonesia and have various phytochemical properties and pharmacological effects. The objective of this research is to determine the cytotoxicity of green leaves and red betel leaves. This research was conducted in two main stages: first, the extraction and preparation through the soxhletation method; second, a cytotoxicity test through the brine shrimp (Artemia salina Leach) lethality test (BSLT). The results showed that there were lethal concentration 50 % (LC50) value in both green betel leaves ethanolic extract and red betel leaves ethanolic extract, with 44.975 μg per mL and 31.556 μg per mL, respectively. The red betel (leaves ethanolic extract has a higher cytotoxicity than green betel (leaves ethanolic extract which can be seen from the lower lethal concentration of 50% (LC50) value. The difference in cytotoxicity is due to differences in plant varieties that cause variations in phytochemical content which affects the pharmacological effects. The green betel leaves ethanolic extract and the red betel leaves ethanolic extract are cytotoxic and have potential anticancer properties.

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Antioxidant activity of eugenol in Piper betel leaf extract

Cited by 25 publications

References 20 publications

Changes in Browning Degree and Reducibility of Polyphenols during Autoxidation and Enzymatic Oxidation

Changes in Browning Degree and Reducibility of Polyphenols during Autoxidation and Enzymatic Oxidation

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Brine Shrimp (Artemia salina Leach.) Lethality Test of Ethanolic Extract from Green Betel (Piper betle Linn.) and Red Betel (Piper crocatum Ruiz and Pav.) through the Soxhletation Method for Cytotoxicity Test

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