Antioxidant and antibacterial activities of ethanol extract of Vernonia amygdalina Delile. Leaves

Harahap

2022

SR: PS

Self Cite

The thinness and sensitivity of the skin in the area under the eyes cause the skin in this area to easily show signs of aging. Hydrogel masks contain quite a lot of water, so during use this mask will moisturize the skin longer. A hydrogel eye mask containing yellow potato tuber water extract is used for the prevention of premature aging, especially under the eyes. The purpose of this study was to determine whether hydrogel eye mask preparations containing water extract of yellow potato tubers can provide an anti-aging effect. Material and methods: The yellow potato tuber water extract was screened for phytochemicals, then formulated into a hydrogel eye mask with a concentration of 0.25 %, 0.5 %, and 1 %. Evaluation of the hydrogel eye mask preparation includes organoleptic, weight, thickness, pH test, tensile test, swelling power, shrinkage, stability, cycling test, hedonic test, and anti-aging. Anti-aging parameters measured include moisture, pores, blemishes, and wrinkles. The treatment was carried out for four weeks by applying the mask twice a week. Results: The results showed that all hydrogel eye mask formulas were stable during storage and cycling tests. All formulas meet pH values, shrinkage, elasticity, swellability, and irritation tests. The hedonic test on volunteers shows the most preferred concentration of 1 %. The results of the anti-aging effectiveness test of the best hydrogel eye mask preparation is a concentration of 1 % with an increase in humidity of 27 %, a decrease in pores of 35.8 %, blemishes of 40 %, and wrinkles of 37.6 Conclusion: That the different concentrations of each formula showed different anti-aging activities and the best formula was 1 % with moisture values of 27 %, pore values of 35.8 %, blemishes of 40 %, and wrinkles values of 37.6 %, which indicated anti-aging activity

Section: Saponinmentioning

confidence: 99%

“…Vitamin C and flavonoids are chemical com-pounds present in potatoes that have antioxidant activity. Vitamin C can function as an oxygen scavenger by transferring hydrogen atoms to oxygen so that oxygen is not available for subsequent reactions [7,8].…”

Section: Introductionmentioning

confidence: 99%

Utilization of water extract of yellow potato (Solanum tuberosum L.) in hydrogel eye mask as anti-aging formulation

Mawalia

Harahap

2022

SR: PS

Self Cite

“…Incubated at 36 oC for 24 hours, the treatment was repeated three times. Then the zone of inhibition was measured with a caliper (mm) [14], [15].…”

Section: Determination Of Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Antibacterial Potential Of Ethanol Extract Of Tamarind Seed Bark (Tamarindus indica L.) And Formulation Of Anti-Acne Nanogel

Amalyuri

International Journal of Science, Technology & Management

Dalimunthe

2022

Acne is a skin disease that affects a large number of sufferers. Acne occurs due to active oil glands under the skin. This activity is stimulated by androgen hormones. The active compound content of proanthocyanidin is the main compound in the ethanolic extract of tamarind seed bark, which can inhibit the growth of acne-causing bacteria, namely Propionibacterium acnes and Staphylococcus epidermidis. The purpose of this study was to formulate a nanogel from tamarind seed bark extract and test the antibacterial potential of an ethanol extract of tamarind seeds against acne-causing bacteria. The antibacterial potency test consisted of variations in concentration and was 0.5, 1, 5, 25, 50, 75, 100, 125, 150, and 300 (in mg/mL). The concentration of the formulated nanogel preparations was 2.5%, 5%, and 7.5%. The MIC results showed that the minimum inhibitory concentration (MIC) was at a concentration of 1 mg/mL with a zone of inhibition of 6.50 ± 0.44 mm (Propionibacterium acnes) and 6.40 ± 0.10 mm (Staphylococcus epidermidis). The minimum bactericidal concentration (MBC) was at a concentration of 25 mg/mL with a percentage reduction of 98.18% (Propionibacterium acnes) and 98.06% (Staphylococcus epidermidis). The results of the nanogel formulations showed that the particle sizes were 49.88 ± 0.11 nm (Formula I), 51.92 ± 0.09 nm (Formula II), and 59.13 ± 0.10 nm (Formula III). Conclusion The ethanolic extract of tamarind seed bark has effectiveness in inhibiting the growth of acne-causing bacteria and can be formulated as an anti-acne nanogel.

“…Vitamin E has an IC 50 of 8.27 g/ml. The smaller the IC 50 value, the higher the antioxidant activity [11,12].…”

Section: Test Anti-aging Activity In a Face Scrub Preparation That Co...mentioning

confidence: 99%

Test anti-aging activity in a face scrub preparation that contains coffee-grade active charcoal (Coffea arabica L.) with the addition of vitamin E

Ratmelya

Harahap

2022

SR: PS

Ageing can be caused by accumulating excess dead skin cells on the skin's surface. Coffee grounds are a by-product of the coffee brewing process. Coffee grounds can be used as activated charcoal in face scrub preparations. The purpose of this study was to formulate and test the effectiveness of anti-ageing face scrub preparations of coffee grounds activated charcoal (Coffea arabica L.) with the addition of vitamin E. Material and methods: the research method includes processing coffee grounds in the form of drying and making activated charcoal, then formulating into face scrub preparations with a concentration of 1 %; 2 %, 3 % with vitamin E, 5 % and without vitamin E and blanc (without activated charcoal). Evaluation of face scrub preparations includes homogeneity test, stability test (odour, colour, pH and consistency), cycling test, dispersion test, viscosity test, centrifugation test, hedonic test, irritation test, and effectiveness test (moisture, pores, stains, wrinkles) on facial skin using a skin analyser on 24 volunteers with application to the face once a week for 4 weeks. The experimental data were analysed using the SPSS 22 program. Results: they showed that all face scrub preparations were in the form of cream with grey-black granules, coffee-scented, homogeneous, stable for 12 weeks of storage at room temperature (20-25°C), pH value (5.0-6.0), had a spreading power of 5-7 cm, viscosity (3760-3996 mPa's), no separation occurs in the centrifugation test and does not irritate facial skin. The results of the hedonic test, the most preferred formulation, was the F3 preparation. The effectiveness test results were an increase in humidity of 27 %, a decrease in pore size of 35.8 %, stains of 40 % and wrinkles of 37.6 %. Conclusion: from the results of the study, it can be concluded that the face scrub preparation of activated charcoal coffee grounds (Coffea arabica L.) with a concentration of 3 % and vitamin E 5 % is a formula that meets the evaluation of the preparation and measures the effectiveness of anti-ageing