Antioxidant and cytoprotective properties of loganic acid isolated from seeds of <i>Strychnos potatorum</i> L. against heavy metal induced toxicity in PBMC model

The various complications related to diabetes are due to the alteration in plasma components and functional activity of blood cells, hence the search for preventive remedies that would ameliorate the clinical condition of patients is a relevant problem today. The main aim of the present study was to examine the antidiabetic potency and antioxidant effects of loganic acid (LA) in blood of diabetic rats. LA showed a restoration of balance between functioning of antioxidant defense system and oxidative stress in leukocytes without notable effects on blood glucose levels when administered orally to rats (20 mg/kg b.w./day) for 14 days. LA ameliorated antioxidant status in leukocytes, as indicated by increasing the content of reduced glutathione and activities of catalase, glutathione peroxidase and glutathione reductase along with decreasing levels of intracellular reactive oxygen species. In addition, we observed the ability of LA to protect against formation and accumulation of glycation and oxidation protein products and malondialdehyde derivates in plasma. Therefore, LA showed antioxidant properties that may have beneficial effects under diabetes. Such results may represent LA as one of the plant components in the development of new drugs that will correct metabolic and functional disorders in leukocytes under diabetes.

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“…Therefore, LA inhibits the generation of ROS and LPO. The free radical scavenging activity of LA was also demonstrated by Abirami et al [49].…”

Section: Discussionsupporting

confidence: 52%

Loganic Acid, an Iridoid Glycoside Extracted from Cornus mas L. Fruits, Reduces of Carbonyl/Oxidative Stress Biomarkers in Plasma and Restores Antioxidant Balance in Leukocytes of Rats with Streptozotocin-Induced Diabetes Mellitus

Dzydzan

Brodyak

Sokół‐Łętowska

et al. 2020

Life

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“…In addition, a positive significant relationship was found between 3-Caffeoylquinic acid-FRAP, 3-Caffeoylquinic acid -PBD, isogentisin-FRAP, and isogentisin-CUPRAC. As far as our literature survey could as certain, the antioxidant properties of these molecules have already been demonstrated and reported in the literature (Abirami et al, 2022;Alcázar Magaña et al, 2021;Badhani et al, 2015;Boz, 2015;Enogieru et al, 2018;Gao et al, 2019;Li et al, 2021).…”

Section: Antioxidant Capacitymentioning

confidence: 61%

“…Interestingly, the extracts were found to be rich in iridoids such as sweroside which has been found to possess important anti‐inflammatory activities (Wang et al, 2019; Zhang et al, 2019). Moreover, loganic acid present in high amounts in stem bark extracts of A. djalonensis from Mafiblé, has been previously reported to exert strong free radical scavenging activity and notable cyto‐protective effect (Abirami et al, 2022). In brief, the stem bark methanolic extract of Mafiblé yielded the highest total bioactive contents, followed by the stem bark‐infusion and leaves‐methanol extract.…”

Section: Resultsmentioning

confidence: 99%

Chemical characterization and biological abilities of Anthocleista djalonensis collected from two locations of Ivory Coast

Sinan

Zengin

Uba³

et al. 2023

eFood

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In this study, the total phenolic and flavonoid contents, HPLC‐DAD detected phytochemicals, antioxidant and enzyme inhibitory potential of methanolic and aqueous (as infusion) extracts of the medicinal plant, Anthocleista djalonensis (leaf and stem bark) collected from two locations, Mafiblé and Prikro, in Ivory Coast, were investigated. The ranges of total phenolic and flavonoid contents obtained were 14.17–46.95 mg gallic acid equivalent (GAE)/g and 2.96–34.76 mg rutin equivalent (RE)/g, respectively. Antioxidant abilities in terms of radical scavenging, reducing and metal chelating activity of the extracts in different assays were as follows: DPPH (4.90–48.82 mg trolox equivalent [TE]/g), ABTS (21.05–81.89 mg TE/g), CUPRAC (29.54–122.33 mg TE/g), FRAP (17.53–94.06 mg TE/g) and metal chelating (10.09–28.49 mg EDTAE/g. The extracts of A. djalonensis collected from Mafiblé, especially those of stem bark, contained higher level of total bioactive contents compared to Prikro extracts, detected by high‐performance liquid chromatography with photodiode‐array detection (HPLC‐DAD). Only the methanolic extracts irrespective of plant parts/location, showed inhibition against acetylcholinesterase (1.42–2.12 mg galantamine equivalent (GALAE)/g), while only the stem bark methanolic extract of A. djalonensis from Mafiblé was found to inhibit butyrylcholinesterase (0.65 mg GALAE/g). Thus, findings from this study could be useful for better application of the medicinal benefits from this plant.

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“…Even though the cornelian cherry juice contained the lowest concentration of polyphenols, it had the highest antioxidant activity estimated by the DPPH assay, probably due to the high concentration of loganic acid. It was observed that loganic acid had remarkable antioxidant activity in terms of DPPH scavenging [62], so its high concentration in cornelian cherry juice compensated antioxidant activity. The other two methods, FRAP and CUPRAC, are based on the reduction of metal ions by the action of antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Compounds, Antioxidant Activity, and Antiproliferative Potential on Glioblastoma Cells of Selected Stone Fruit Juices

Raucher,

Rowsey,

Hinson

et al. 2024

Processes

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Glioblastoma presents one of the most formidable challenges in cancer treatment, remaining persistently incurable. There is a pressing need to explore less toxic alternatives, particularly natural remedies that could be applied in glioblastoma therapy. The aim of this research is to investigate the antiproliferative potential of selected stone fruit juices—tart cherry (Prunus cerasus), cornelian cherry (Cornus mas), and blackthorn (Prunus spinosa)—on U87-MG and GBM43 glioblastoma cells. Their effects were compared with temozolomide (TMZ), the current standard treatment. Additionally, the juices were assessed for their bioactive compounds and antioxidant potential. Unlike the other two juices, blackthorn juice did not exhibit an antiproliferative effect on U87-MG cells. However, all three juices, including blackthorn, demonstrated antiproliferative potential against TMZ-resistant GBM43 cells. Cornelian cherry exhibited an even stronger inhibitory effect than TMZ. This observation correlated with cornelian cherry being rich in iridoids, while tart cherry juice contained significant amounts of anthocyanins and proanthocyanidins. This research sheds light on the potential of cornelian cherry juice as a source of bioactive compounds with antiproliferative effects against glioblastoma cells, particularly TMZ-resistant GBM43 cells. Further research is warranted to explore the potential development of these compounds into therapeutic agents, either as single entities or in combination therapies for glioblastoma treatment.

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Antioxidant and cytoprotective properties of loganic acid isolated from seeds of Strychnos potatorum L. against heavy metal induced toxicity in PBMC model

Cited by 18 publications

References 58 publications

Loganic Acid, an Iridoid Glycoside Extracted from Cornus mas L. Fruits, Reduces of Carbonyl/Oxidative Stress Biomarkers in Plasma and Restores Antioxidant Balance in Leukocytes of Rats with Streptozotocin-Induced Diabetes Mellitus

Loganic Acid, an Iridoid Glycoside Extracted from Cornus mas L. Fruits, Reduces of Carbonyl/Oxidative Stress Biomarkers in Plasma and Restores Antioxidant Balance in Leukocytes of Rats with Streptozotocin-Induced Diabetes Mellitus

Chemical characterization and biological abilities of Anthocleista djalonensis collected from two locations of Ivory Coast

Bioactive Compounds, Antioxidant Activity, and Antiproliferative Potential on Glioblastoma Cells of Selected Stone Fruit Juices

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