2014
DOI: 10.4330/wjc.v6.i6.462
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Antioxidants, inflammation and cardiovascular disease

Abstract: Multiple factors are involved in the etiology of cardiovascular disease (CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells, leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species (ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxi… Show more

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Cited by 293 publications
(205 citation statements)
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“…16 Reactive nitrogen species (RNS) 17 in addition to reactive oxygen species (ROS) 18 have important role in oxidative stress conditions, especially inflammation. In recent years, the protective effects of antioxidants have been proved in inflammation 19 and provide a new insight in order to reduce…”
Section: Introductionmentioning
confidence: 99%
“…16 Reactive nitrogen species (RNS) 17 in addition to reactive oxygen species (ROS) 18 have important role in oxidative stress conditions, especially inflammation. In recent years, the protective effects of antioxidants have been proved in inflammation 19 and provide a new insight in order to reduce…”
Section: Introductionmentioning
confidence: 99%
“…3 Via the induction of an increased inflammatory response, oxidative stress leads to the onset and progression of many diseases, including cardiovascular disease (CVD). 4 High levels of free sulfhydryl groups (R-SH) may be a reflection of a favorable redox status since they avidly interact with ROS and other reactive species. 5 In healthy individuals, the concentrations of serum protein thiols are highly regulated 6 and form part of an intricate redox network that underpins human adaptation to nutritional, metabolic and environmental challenges.…”
Section: Introductionmentioning
confidence: 99%
“…An excessive ROS production is responsible for the oxidation of LDL [52] , which may promote the transformation of macrophages into foam cells, which represent the first step in the formation of the atherosclerotic lesion. On the other hand, in patients with NAFLD, ROS may also cause lipid peroxidation which may be followed by inflammation, and activation of stellate cells leading to fibrogenesis [8] .…”
Section: Imtmentioning
confidence: 99%