Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts

Kang, Hyunil; Oh, Yuri; Lee, Sihyeong; Ryu, In Wang; Kim, Kyunghoon; Lim, Chang‐Jin

doi:10.1080/09168451.2015.1065170

Cited by 15 publications

(10 citation statements)

References 19 publications

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“…2). Previous researches on ginsenoside Ro mostly involved in the anti-inflammatory 28, 29 , thrombosis prevention 30, 31 and anti-oxidation 32 . The most eye-catching newly discovery of ginsenoside Ro is its autophagy inhibition activity, which beyond several other ginsenosides extraceted form Panax ginseng 33 .…”

Section: Discussionmentioning

confidence: 99%

The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

Zhou

Qian

Dong

et al. 2017

Sci Rep

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Our recent biosystems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which suggests that abortifacients may be good for safe and effective metastatic chemoprevention targeting circulating tumor cells (CTC). Here we test the hypothesis by using the well-known abortion herb Achyranthes bidentata Blume (A. bidentata). Five compounds were separated from the herb root. Among them, ginsenoside Ro was the most potent in inhibiting embryonic implantation within non-cytotoxic concentrations. It specifically inhibited the metastatic dissemination capability of colon cancer cells HT29, including the migration and invasion ability, and their adhesion to human endothelium through inhibiting integrin αvβ6, MMP-2, MMP-9, and ERK phosphorylation by HT29. Pretreatment of nude mice with oral ginsenoside Ro followed by HT29 intravenous inoculation and 40-day oral ginsenoside Ro significantly prevented lung metastasis with downregulation of integrin αvβ6 and no toxicity. The present study firstly introduces the new conception of utilizing safe and effective abortion botanic medicines for CTC-based metastatic chemoprevention.

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Section: Discussionmentioning

confidence: 99%

The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

Zhou

Qian

Dong

et al. 2017

Sci Rep

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“…Activated NF‐κB eventually binds to κB elements in the promoter region of target genes and initiates the transcriptional process of numerous genes . Recent investigations have demonstrated that the NF‐κB pathway is suppressed by a large number of ginsenosides, including Rg1, Rh2, Rb1, Compound K (CK), Rg3, Rb3, Rd, Pseudoginsenoside‐F11 (PF11), Re, Rh1, Rf, 20( S )‐protopanaxatriol, and Ro (Fig. ).…”

Section: Cellular Stress Response Mechanisms Regulated By Ginsenosidesmentioning

confidence: 93%

“…NF‐κB‐mediated activation of downstream genes is proposed to be closely correlated with inflammation‐associated cancer . Through inactivating the NF‐κB pathway, ginsenosides exhibit an inhibitory effect on human cancer in the following three aspects: (1) cancer metastasis was shown to be blocked by three different ginsenosides.…”

Section: Cellular Stress Response Mechanisms Regulated By Ginsenosidesmentioning

confidence: 99%

Cellular stress response mechanisms as therapeutic targets of ginsenosides

2017

Medicinal Research Reviews

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Ginseng, one of the most widely used traditional herbal medicines and dietary supplements, has historically been recognized as a tonic herb and adaptogen that can enhance the body's tolerance to various adversities. Ginsenosides are a diverse group of steroidal saponins that comprise the major secondary metabolites of ginseng and are responsible for its multiple pharmacological effects. Emerging evidence suggests that hormetic phytochemicals produced by environmentally stressed plants can activate the moderate cellular stress response mechanisms at a subtoxic level in humans, which may enhance tolerance against severe dysfunction or disease. In this review, we initially describe the role of ginsenosides in the chemical defense of plants from the genus Panax suffering from biotic and abiotic stress. Next, we summarize the diverse evolutionarily conserved cellular stress response pathways regulated by ginsenosides and the subsequent stress tolerance against various dysfunctions or diseases. Finally, the structure-activity relationship involved in the effect of ginsenosides is also analyzed. The evidence presented in this review implicates that ginseng as "the King of all herbs" could be regarded as a well-characterized example of the critical role of cellular stress response mechanisms in understanding the health benefits provided by herbal medicines from an evolutionary and ecological perspective.

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“…Re, which is a PPT-type ginsenoside, was demonstrated to preserve skin barrier functionality, via enhancing CE formation, and potentiating filaggrin and caspase-14 activity in skin cells under physiological conditions (43). Ro, an oleanolic acid-type ginsenoside, also exhibited anti-photoaging potential by counteracting the UVB-induced decrease in fibroblast GSH contents (44). These previous findings suggested that ginsenosides may exert beneficial actions on human skin; however, the mechanisms underlying their effects may vary depending on the type of ginsenoside and their stereospecificity.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rc protects against UVB-induced photooxidative damage in epidermal keratinocytes

Lim²,

Park

et al. 2017

Molecular Medicine Reports

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Ginsenoside Rc (Rc) is a major ginsenoside isolated from Panax ginseng, and has exhibited pharmacological effects on skin cells. The present study aimed to investigate the putative skin‑protective properties of Rc, including its anti‑photoaging and barrier function‑protective effects, in human HaCaT keratinocytes exposed to UVB radiation. The protective properties of Rc were evaluated through the assessment of keratinocyte viability, reactive oxygen species (ROS) production, total glutathione (GSH) and superoxide dismutase (SOD) activity, caspase‑14, matrix metalloproteinase (MMP)‑2 and ‑9 activity, and MMP‑2, MMP‑9 and filament aggregating protein (filaggrin) expression following UVB irradiation. Treatment with Rc was revealed to prevent the UVB‑induced increase in ROS production and pro‑MMP‑2 and ‑9 levels in HaCaT keratinocytes. In addition, treatment with Rc resulted in enriched GSH contents and enhanced SOD activity following exposure to UVB radiation. Furthermore, Rc treatment enhanced caspase‑14 activity and counteracted the UVB‑induced downregulation in filaggrin expression. However, no significant difference was identified between Rc‑treated and normal groups in terms of keratinocyte viability, regardless of exposure to radiation. The present findings suggested that Rc may exert anti‑photoaging and barrier function‑protective effects in keratinocytes, and thus protect the skin against photooxidative stress induced by exposure to UV radiation.

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Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts

Cited by 15 publications

References 19 publications

The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

Cellular stress response mechanisms as therapeutic targets of ginsenosides

Ginsenoside Rc protects against UVB-induced photooxidative damage in epidermal keratinocytes

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