Antiprotozoal activity of silver nanoparticles against Cryptosporidium parvum oocysts: New insights on their feasibility as a water disinfectant

Hassan, Dalia; Farghali, Mohamed; Eldeek, Hanan E. M.; Gaber, Mona; Elossily, Nahed Ahmed; Ismail, Taghreed

doi:10.1016/j.mimet.2019.105698

Cited by 27 publications

(19 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean oocysts count of the seven treated groups varied from the 2 nd day to the 14 th day posttreatment and then reduced gradually till the experimental end on the day 19 th . Fluctuation phenomenon of oocyst shedding was reported by Hassan et al (2019) who found a rebound increase of Cryptosporidium oocysts number and viability or rebound phenomenon which included reinfection, autoinfection activation with thin-wall oocysts and/or inhibited stages reactivation. But, De Waele et al (2012) reported that the patient could be infected with different Cryptosporidium species.…”

Section: Introductionmentioning

confidence: 78%

The Potential Convention of Garlic and Black Seed Different Extracts as an Effective Treatment of Cryptosporidium Spp. : An Experimental Study

Sadek¹,

Abdel-Rahman

Bakir

et al. 2020

Journal of the Egyptian Society of Parasitology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 78%

The Potential Convention of Garlic and Black Seed Different Extracts as an Effective Treatment of Cryptosporidium Spp. : An Experimental Study

Sadek¹,

Abdel-Rahman

Bakir

et al. 2020

Journal of the Egyptian Society of Parasitology

View full text Add to dashboard Cite

“…Moreover, AgNPs significantly decrease oocyst viability of Cryptosporidium parvum in a dose-dependent manner, between concentrations of 0.005 and 500 μg/ml (34). Additionally, AgNPs at a concentration of 1 ppm for 30 min and 0.1 ppm for 1 h reduced the viability of Cryptosporidium oocysts by 97.2 and 94.4%, respectively (35).…”

Section: Discussionmentioning

confidence: 99%

Influence of chemically and biosynthesized silver nanoparticles on in vitro viability and infectivity of Trichinella spiralis muscle larvae

Dyab

Abd-ELrahman

Mahmoud

et al. 2021

Preprint

View full text Add to dashboard Cite

Back groundTrichinellosis is a serious worldwide parasitic zoonosis. The available therapy for the treatment of Trichinella spiralis is not satisfactory. This work aimed at evaluating of the in vitro effect of silver Therefore, the recovery of effective treatment is required.nanoparticles (AgNPs) on muscle larvae of Trichinella.Methodology / principal findingThe present study investigated the larvicidal properties of chemical and myrrh AgNPs on muscle larvae (ML) of T. spiralis. The used AgNPs were chemically prepared using NaBH4 as reducing agent and biosynthesized using methanolic myrrh extract. Characterization of synthesized AgNPs was monitored via UV-Vis spectrophotometry, Fourier transform infrared spectroscopy and transmission electron microscopy (TEM) studies. The ML incubated with AgNPs at concentrations ranged from 1μg/ml to 20μg/ml.Conclusions /SignificanceChemical and biosynthesized AgNPs revealed marked larvicidal effect against ML of Trichinella. Additionally, this in vitro study showed degenerative changes affecting the cuticle of AgNPs treated ML. The effectiveness of AgNPs on the infectivity of Trichinella ML was also assessed. The results showed complete inhibition of the infectivity of ML exposed to sublethal doses of chemical and myrrh prepared AgNPs when used to infect animal models. This is the first report where myrrh synthesized AgNPs have been tested for their anthelminthic activity against Trichinella in an in vitro model.Author summaryTrichinellosis is a serious worldwide parasitic zoonosis. The available therapy for the treatment of Trichinella spiralis is not satisfactory. Therefore, the recovery of effective treatment is required. The present study investigated the larvicidal properties of chemical and myrrh AgNPs on muscle larvae (ML) of T. spiralis. The ML incubated with AgNPs at concentrations ranged from 1μg/ml to 20μg/ml. Chemical and biosynthesized AgNPs revealed marked larvicidal effect against ML of Trichinella. Additionally, this in vitro study showed degenerative changes affecting the cuticle of AgNPs treated ML. Also the results showed complete inhibition of the infectivity of ML exposed to sublethal doses of chemical and myrrh prepared AgNPs when used to infect animal models.

show abstract

“…Silver nanoparticles (Ag NPs) proved effective against both extracellular and intracellular parasites (Adeyemi et al, 2018). It significantly decreased the Cryptosporidium parvum oocysts count and viability in a safe, effective and cheap manner (Hassan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and Immuno-Modulatory Effect of Silver Nanoparticles-Loaded With Metronidazole on Experimental Blastocystosis

Ahmed

Kamal

Mohamed

et al. 2021

Journal of the Egyptian Society of Parasitology

View full text Add to dashboard Cite

Antiprotozoal activity of silver nanoparticles against Cryptosporidium parvum oocysts: New insights on their feasibility as a water disinfectant

Cited by 27 publications

References 47 publications

The Potential Convention of Garlic and Black Seed Different Extracts as an Effective Treatment of Cryptosporidium Spp. : An Experimental Study

The Potential Convention of Garlic and Black Seed Different Extracts as an Effective Treatment of Cryptosporidium Spp. : An Experimental Study

Influence of chemically and biosynthesized silver nanoparticles on in vitro viability and infectivity of Trichinella spiralis muscle larvae

Therapeutic and Immuno-Modulatory Effect of Silver Nanoparticles-Loaded With Metronidazole on Experimental Blastocystosis

Contact Info

Product

Resources

About