Antitumor Activity of Cleome Viscosa Against Ehrlich Ascites Carcinoma (Eac) in Swiss Albino Mice

The study aims to determine the hepatoprotective effect of n-hexane, ethyl acetate, and methanol extracts of the leaves and stems of two Cleome species against carbon tetrachloride- (CCl4-) induced liver toxicity both in vitro using human hepatoma (HepG2) cells and in vivo in rats as well as the hepatoprotective property of all isolated compounds on HepG2. After 72 h of treatment, at the concentrations of 25, 50, and 100 μg/mL, the methanol of C. chelidonii stems (CCSM) ranged from 18.6% to 20.8%, whereas the methanol of C. chelidonii stems (CVSM) increased from 12.3% to 17.2% cell viability. The results show that CCSM and CVSM significantly expressed in vitro hepaprotective activity on HepG2. Therefore, the animals were daily treated with these extracts at the doses of 15, 30, and 45 mg/kg body weight for 5 days, and CCl4 was injected (2 ml/kg body weight, i.p.) on the 2nd and 3rd days. Levels of aspartate aminotransferase (ALT) and alanine aminotransferase (AST) in the blood were measured and compared to the silymarin control. The treatments with CCSM and CVSM (30, and 45 mg/kg) possessed significant hepatoprotection and were comparable with the activity of silymarin. Further, phytochemical studies of these ones were conducted and led to the identification of eight flavonoids: visconoside A (1), visconoside B (2), quercetin 3-O-β-D-glucopyranoside 7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-β-D-glucopyranoside 7-O-α-L-rhamnopyranoside (4), cleomeside A (5), cleomeside B (6), cleomeside C (7), and quercetin-3-O-[β-D-glucopyranosyl-(1⟶2)]-α-L-rhamnopyranoside 7-O-α-L-rhamnopyranoside (8). Two major flavonoids (1 and 4) displayed significant hepatoprotective property (at the concentration of 100 μM, the prevention percentage values were 66.5% and 74.2%, respectively, compared to the quercetin control, with value of 80.3%).

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Review on Cleome Viscosa Linn Plant with their various Biological and Pharmacological Activities

S Andhale,

S Bhosale,

S Aher

2024

AJPS

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Viscosa cleome Linn. (Capparidaceae), sometimes known as “wild or dog mustard,” is an annual, sticky herb that grows as a common weed across the tropics and on the plains of India. In traditional and folkloric systems, the entire plant and its components (leaves, seeds, and roots) are frequently used. Medical field. According to traditional medical systems, the plant has positive effects as an Carminative, antiscorbutic, sudorific, febrifuge, anthelmintic, antiseptic, sudorific, stimulant of the heart, and sudorific. Following The numerous historical assertions that C. viscosa (CV) can treat a wide range of illnesses, significant Researchers have made an effort to confirm its usefulness by pharmacological testing. Pharmacological research have revealed that CV has a number of noteworthy biological actions, including hepatoprotective, immunomodulatory, analgesic, antipyretic, immunoregulatory, antihelminthic, antibacterial, psychopharmacological, antidiarrheal, and antipyretic properties. The plant has produced a wide range of phytoprinciples that have been isolated. The goal of the current review is to combine traditional, ethnobotanical, and phyto-Information about C. viscosa’s chemistry and pharmacology is currently accessible.

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Antitumor Activity of Cleome Viscosa Against Ehrlich Ascites Carcinoma (Eac) in Swiss Albino Mice

Cited by 4 publications

References 20 publications

“Evaluation of anti-breast cancer, anti-angiogenic and antioxidant properties of selected medicinal plants”

“Evaluation of anti-breast cancer, anti-angiogenic and antioxidant properties of selected medicinal plants”

Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems

Review on Cleome Viscosa Linn Plant with their various Biological and Pharmacological Activities

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