2013
DOI: 10.1186/1477-3155-11-41
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Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine

Abstract: BackgroundThe increasing incidence of cancer and the search for more effective therapies with minimal collateral effects have prompted studies to find alternative new treatments. Among these, photodynamic therapy (PDT) has been proposed as a very promising new modality in cancer treatment with the lowest rates of side effects, revealing itself to be particularly successful when the photosensitizer is associated with nanoscaled carriers. This study aimed to design and develop a new formulation based on albumin … Show more

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Cited by 45 publications
(31 citation statements)
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“…Photodynamic therapy (PDT) is a promising treatment for cancer and non-oncological diseases. [1][2][3][4] It combines a photosensitizer drug (PS, organic dye) with visible light irradiation in the range of the electromagnetic spectrum of appropriate wavelength, and oxygen, each of which alone is harmless. The photodynamic effect produces reactive oxygen species (ROS), which function as lethal cytotoxic agents that inactivate tumor cells, bacteria and other living species.…”
Section: Introductionmentioning
confidence: 99%
“…Photodynamic therapy (PDT) is a promising treatment for cancer and non-oncological diseases. [1][2][3][4] It combines a photosensitizer drug (PS, organic dye) with visible light irradiation in the range of the electromagnetic spectrum of appropriate wavelength, and oxygen, each of which alone is harmless. The photodynamic effect produces reactive oxygen species (ROS), which function as lethal cytotoxic agents that inactivate tumor cells, bacteria and other living species.…”
Section: Introductionmentioning
confidence: 99%
“…The fact that these methods have many side‐effects which has led to the search for more effective and less side‐effect treatments. Among these new therapies, photodynamic therapy (PDT) is known to be the most promising treatment method for cancer treatment and has the least side‐effect …”
Section: Introductionmentioning
confidence: 99%
“…With ultraviolet (UV) illumination, ZnO nanomaterials can generate cytotoxic reactive oxygen species (ROS) to kill tumor cells. Usually, the limitation of PDT to superficial malignant neoplasm is considered as its shortcoming since the UV light cannot penetrate deeply into human tissues [913]. However, just as fire is a good servant but a bad master, it is precisely the point of interest in the study.…”
Section: Introductionmentioning
confidence: 99%