Antitumor Microbial Products by Actinomycetes Isolated from Different Environments

Guimarães, Tábata Cristina; Gomes, Thiara Santana; Fernandes, Clara Dourado; Barros, Fernanda Dantas; Oliveira, Kamila Valença; Bilal, Muhammad; Bharagava, Ram Naresh; Ferreira, Luiz Fernando Romanholo; Hollanda, Luciana Maria de

doi:10.1007/978-981-15-2679-4_5

Cited by 3 publications

(2 citation statements)

References 188 publications

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“…Benzastatins molecule comprises of N-H and one hydroxyl group, while benzastatins derivatives have methoxy group. Due to these functional groups’ presence, weaker lipid peroxidation compared to vitamin E was demonstrated from these compounds [ 65 , 66 ]. Several compounds such as antiostatins A1 to A4 and B1 to B4 reported from S. cyaneus , and carbazoquinocins A to F isolated from S. violaceus , were composed of carbazole comprising an o-quinone.…”

Section: Microorganisms As a Source Of Antioxidant Compoundsmentioning

confidence: 99%

Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications

et al. 2021

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Oxidative stress originates from an elevated intracellular level of free oxygen radicals that cause lipid peroxidation, protein denaturation, DNA hydroxylation, and apoptosis, ultimately impairing cell viability. Antioxidants scavenge free radicals and reduce oxidative stress, which further helps to prevent cellular damage. Medicinal plants, fruits, and spices are the primary sources of antioxidants from time immemorial. In contrast to plants, microorganisms can be used as a source of antioxidants with the advantage of fast growth under controlled conditions. Further, microbe-based antioxidants are nontoxic, noncarcinogenic, and biodegradable as compared to synthetic antioxidants. The present review aims to summarize the current state of the research on the antioxidant activity of microorganisms including actinomycetes, bacteria, fungi, protozoa, microalgae, and yeast, which produce a variety of antioxidant compounds, i.e., carotenoids, polyphenols, vitamins, and sterol, etc. Special emphasis is given to the mechanisms and signaling pathways followed by antioxidants to scavenge Reactive Oxygen Species (ROS), especially for those antioxidant compounds that have been scarcely investigated so far.

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Section: Microorganisms As a Source Of Antioxidant Compoundsmentioning

confidence: 99%

Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications

et al. 2021

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“…In this chapter, we will focus on the uses of microbial secondary metabolites as antioxidants, antibiotics, antitumor and polymers from mainly Streptomyces genus, which have been important in soil bioremediation and biocatalysis for the obtention of enantiopure compounds [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Microorganisms as Alternative Sources of New Natural Products

Cabello¹

2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

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Microbial natural products have become important over the last decades due to the ability of bacteria and fungi to subsist in different habitats such as marine and extreme environments. Microorganisms are able to synthesize new compounds with diverse therapeutic activity equal to or better than the activity of compounds already known, thus being promising for the treatment of different diseases such as cancer or the solution to health problems such as antibiotic resistance. The production of microbial natural compounds can be improved by modifying culture media, growing conditions, amplifying gene expression or by co-cultivation techniques, which are the major challenges in the industrial production of such compounds.

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Fruit wrapping kraft coated paper promotes the isolation of actinobacteria using ex situ and in situ methods

et al. 2021

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Antitumor Microbial Products by Actinomycetes Isolated from Different Environments

Cited by 3 publications

References 188 publications

Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications

Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications

Microorganisms as Alternative Sources of New Natural Products

Fruit wrapping kraft coated paper promotes the isolation of actinobacteria using ex situ and in situ methods

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