Antitussive Action of L-Propoxyphene in Citric Acid-Induced Cough Response

Calesnick, Benjamin; Christensen, Jens; Munch, James C.

doi:10.1097/00000441-196111000-00005

Cited by 8 publications

(8 citation statements)

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“…The methods that have previously been described to record cough have mostly been nonambulatory, and usually limited to short periods of time, using visible and auditory changes [6][7][8][9][10][11]. Some workers have attempted quantitative determination of cough by allotting marks over a given period by the nursing staff or by the patient himself [4,12,13].…”

mentioning

confidence: 99%

Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder

Hsu¹,

Stone²,

et al. 1994

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C Co ou ug gh hi in ng g f fr re eq qu ue en nc cy y i in n p pa at ti ie en nt ts s w wi it th h p pe er rs si is st te en nt t c co ou ug gh h: : a as ss se es ss sm me en nt t u us si in ng g a a 2 24 4 h ho ou ur r a am mb bu ul la at to or ry y r re ec co or rd de er r ABSTRACT: Cough is an important symptom of many respiratory disorders. We determined the frequency and diurnal variation of cough in normal subjects and in patients with asthma or with persistent cough of unknown cause. We used a portable, solid-state, multiple-channel recorder to record cough sounds over a 24 h period. The audio-signal was recorded from a unidirectional microphone strapped over the chest wall, and electromyographic (EMG) signals from the lower respiratory muscles were simultaneously registered with surface electrodes. The recorded digital data were examined on an IBM-compatible computer, and the typical signals induced by cough (as assessed by voluntary or experimentally-induced cough) were counted.In 12 normal subjects, only 0-16 coughs were recorded over 24 h. In 21 stable asthmatics with a history of chronic cough ("asthma") the median number was 282 (ranges: 45-1,577), and in 14 patients with the predominant symptom of daily dry coughs ("chronic coughers") the median number was 794 (64-3,639). In both groups of patients, there was a diurnal variation of coughs, such that the least numbers occurred between 2 and 5 a.m. (<3% of total). In the asthma group, there was no significant correlation between forced expiratory volume in one second (FEV 1 ) (% predicted) or diurnal variation of peak expiratory flow and cough frequency. In the chronic coughers, there was a significant correlation between daytime cough numbers and daytime cough symptom scores but not for the night-time values.Our data show that cough frequency is not determined by the severity of asthma in relatively stable asthmatics on inhaled steroids, and is reduced during sleep in both asthmatics and chronic cough patients. This portable cough recorder may be useful in the assessment of drug therapy for chronic cough.

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confidence: 99%

Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder

Hsu¹,

Stone²,

et al. 1994

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“…Experimental studies in healthy subjects indicated that 50 and 100 mg. of L-propoxyphene produced a significant diminution in both the frequency and intensity of cough stimulated by irritant aerosols over a 4 hour test period. 10,19 There have been few other pharmacologic effects noted with this preparation. Respiration, as well as the central nervous system generally, is not depressed.…”

Section: :191 1957)mentioning

confidence: 98%

Clinical pharmacology of antitussive agents

Bickerman

1962

Clin Pharma and Therapeutics

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“…Some studies using the flow curve of cough have been published [4][5][6][7][8]. In the flow recording of cough, pneumotachographs are needed which are sensitive enough to enable recording of the rapid flow changes occurring during a cough sequence.…”

Section: The Flow Dynamics Of Coughmentioning

confidence: 99%

“…In the 1950s, pneumographic belt recording of thoracic pressure changes during cough was used by some researchers to study the number of coughs, cough intensity and duration of coughing [3]. Methods using the measurements of airflow during coughing were also used in cough counting in the 1950s [6,7,82]. Unfiltered recording of cough sounds with a free-field microphone and cassette recorder was described in the 1960s [78,83]: the number of cough events was counted off-line by a listener.…”

Section: Cough Countersmentioning

confidence: 99%

“…Since then, several attempts have been made to record cough, based on the movement of the chest [3], airflow measurement at the mouth [4][5][6][7][8], and sound measurement of cough [9][10][11][12]. In cough experiments, cough has been triggered with inhalant irritants, such as citric acid [7,[13][14][15][16] or capsaicin, an important C-fibre stimulating agent [17,18].…”

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Objective assessment of cough

Piirilä¹,

Sovijärvi²

1995

Eur Respir J

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Modern analysing techniques have also been applied in cough sound studies, and differences in cough sound duration and spectra have been found in pulmonary diseases with different bronchopulmonary pathophysiology. Since the objective assessment of cough is clinically important, automatic cough detectors and counters have been constructed, e.g. to assess the efficacy of antitussive drugs. Also, ambulatory methods for assessment of cough have been reported. This review includes a brief history of cough research and present methods available for objective assessment of cough.

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Antitussive Action of L-Propoxyphene in Citric Acid-Induced Cough Response

Cited by 8 publications

References 0 publications

Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder

Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder

Clinical pharmacology of antitussive agents

Objective assessment of cough

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